SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pg1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
4 / 8 PHE A 352
ILE A  79
LEU A  66
VAL A  75
None
0.83A 1fslB-3pg1A:
undetectable
1fslB-3pg1A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_A_SAMA500_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
5 / 12 CYH A 221
PHE A 233
GLY A 235
SER A 236
THR A 237
None
1.32A 1g60A-3pg1A:
undetectable
1g60A-3pg1A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
3 / 3 ASP A 118
HIS A 160
ASP A 176
None
0.76A 1nw5A-3pg1A:
undetectable
1nw5A-3pg1A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
5 / 10 LEU A 300
GLY A 220
ALA A 219
SER A 218
LEU A 159
None
1.03A 1pxxA-3pg1A:
undetectable
1pxxA-3pg1A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
5 / 12 LEU A 300
GLY A 220
ALA A 219
SER A 218
LEU A 159
None
1.03A 1pxxC-3pg1A:
undetectable
1pxxC-3pg1A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
6 / 12 ALA A  49
LEU A  82
LEU A  91
THR A 112
LEU A 149
HIS A 156
None
0.73A 1uwhA-3pg1A:
14.6
1uwhA-3pg1A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
6 / 12 ALA A  49
LEU A  82
LEU A  91
THR A 112
LEU A 149
HIS A 156
None
0.73A 1uwhB-3pg1A:
14.5
1uwhB-3pg1A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
3 / 3 LEU A 110
LEU A 114
MET A 115
None
0.82A 2itzA-3pg1A:
20.4
2itzA-3pg1A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
5 / 12 ILE A 172
ALA A 278
ALA A 280
THR A 282
LEU A 293
None
1.36A 2x2nD-3pg1A:
undetectable
2x2nD-3pg1A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
7 / 12 ALA A  49
THR A 112
LEU A 114
LEU A 165
ASP A 176
PHE A 177
LEU A 179
None
0.96A 3bbtB-3pg1A:
19.8
3bbtB-3pg1A:
26.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
5 / 12 GLU A 102
SER A  67
VAL A 345
TYR A 346
HIS A 106
None
1.40A 3bjmB-3pg1A:
3.1
3bjmB-3pg1A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
5 / 12 MET A 115
VAL A  48
GLY A  92
ILE A  90
ASN A  89
None
1.33A 3bwmA-3pg1A:
undetectable
3bwmA-3pg1A:
21.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
5 / 12 VAL A  37
ALA A  49
LEU A  82
THR A 112
HIS A 156
None
0.32A 3gcsA-3pg1A:
24.7
3gcsA-3pg1A:
36.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
4 / 7 LEU A 110
LEU A 114
MET A 115
ILE A  90
None
0.97A 3gp0A-3pg1A:
34.1
3gp0A-3pg1A:
38.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
4 / 7 LYS A  51
LEU A 114
MET A 115
ILE A  90
None
0.90A 3gp0A-3pg1A:
34.1
3gp0A-3pg1A:
38.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
5 / 12 ALA A  49
LEU A  81
LEU A  82
THR A 112
LEU A 114
None
0.60A 3hecA-3pg1A:
25.1
3hecA-3pg1A:
37.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
5 / 12 VAL A  37
ALA A  49
LYS A  51
LEU A  82
THR A 112
None
0.59A 3hegA-3pg1A:
33.2
3hegA-3pg1A:
37.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
5 / 8 ALA A  49
LYS A  51
LEU A 110
THR A 112
LEU A 114
None
0.37A 3lfaA-3pg1A:
33.9
3lfaA-3pg1A:
37.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
5 / 12 GLY A 209
VAL A 257
ASP A 256
PRO A 201
LEU A 242
None
1.10A 3m6vB-3pg1A:
undetectable
3m6vB-3pg1A:
21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_B_1N1B1000_1
(P38A)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
5 / 12 VAL A  37
ALA A  49
LYS A  51
LEU A  82
THR A 112
None
0.42A 3ohtB-3pg1A:
7.3
3ohtB-3pg1A:
35.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
4 / 5 ILE A 164
ALA A 219
HIS A 141
MET A 139
None
0.98A 4ac9B-3pg1A:
undetectable
4ac9C-3pg1A:
undetectable
4ac9B-3pg1A:
21.30
4ac9C-3pg1A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
4 / 5 ILE A 164
ALA A 219
HIS A 141
MET A 139
None
1.02A 4acaB-3pg1A:
undetectable
4acaC-3pg1A:
undetectable
4acaB-3pg1A:
21.30
4acaC-3pg1A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
5 / 12 LEU A 300
GLY A 220
ALA A 219
SER A 218
LEU A 159
None
1.11A 4coxA-3pg1A:
0.9
4coxA-3pg1A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
5 / 12 LEU A 300
GLY A 220
ALA A 219
SER A 218
LEU A 159
None
1.12A 4coxB-3pg1A:
undetectable
4coxB-3pg1A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
5 / 12 LEU A 300
GLY A 220
ALA A 219
SER A 218
LEU A 159
None
1.11A 4coxD-3pg1A:
undetectable
4coxD-3pg1A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
3 / 3 PRO A  88
ASN A  89
HIS A 141
None
1.02A 4ma3H-3pg1A:
undetectable
4ma3L-3pg1A:
undetectable
4ma3H-3pg1A:
18.63
4ma3L-3pg1A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
5 / 12 LEU A 300
GLY A 220
ALA A 219
SER A 218
LEU A 159
None
1.10A 4otyA-3pg1A:
undetectable
4otyA-3pg1A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
5 / 12 LEU A 300
GLY A 220
ALA A 219
SER A 218
LEU A 159
None
1.10A 4rrwC-3pg1A:
undetectable
4rrwC-3pg1A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
5 / 12 LEU A 300
GLY A 220
ALA A 219
SER A 218
LEU A 159
None
1.10A 4rrzC-3pg1A:
undetectable
4rrzC-3pg1A:
21.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
4 / 6 ALA A  49
LEU A 114
MET A 115
LEU A 165
None
0.78A 4xoyA-3pg1A:
11.8
4xoyA-3pg1A:
39.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
4 / 6 ALA A  49
LEU A 114
MET A 115
LEU A 165
None
0.91A 4xp3A-3pg1A:
32.3
4xp3A-3pg1A:
39.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
5 / 12 MET A 115
VAL A  48
GLY A  92
ILE A  90
ASN A  89
None
1.29A 4xueB-3pg1A:
undetectable
4xueB-3pg1A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
6 / 12 ALA A  49
LEU A  82
LEU A  91
THR A 112
LEU A 149
HIS A 156
None
0.72A 5hi2A-3pg1A:
6.1
5hi2A-3pg1A:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
5 / 10 GLY A 145
ALA A 152
VAL A 148
GLU A 151
ILE A  90
None
1.06A 5i3cB-3pg1A:
undetectable
5i3cB-3pg1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
5 / 11 GLY A 145
ALA A 152
VAL A 148
GLU A 151
ILE A  90
None
1.20A 5i3cC-3pg1A:
undetectable
5i3cC-3pg1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major)
5 / 12 LEU A 300
GLY A 220
ALA A 219
SER A 218
LEU A 159
None
1.04A 5ikqA-3pg1A:
undetectable
5ikqA-3pg1A:
20.18