SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pg7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 3pg7 NEUROFIBROMIN
(Homo
sapiens) 		4 / 5 VAL A1736
GLY A1737
VAL A1741
TRP A1809
 None
 0.74A 1tkqB-3pg7A:
undetectable		 1tkqB-3pg7A:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 3pg7 NEUROFIBROMIN
(Homo
sapiens) 		3 / 3 PHE A1572
TYR A1618
TYR A1614
 PTY  A 400 (-4.6A)
None
None
 0.95A 1x70B-3pg7A:
undetectable		 1x70B-3pg7A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3pg7 NEUROFIBROMIN
(Homo
sapiens) 		5 / 8 TYR A1762
ARG A1590
GLY A1737
THR A1739
ALA A1740
 None
 1.45A 2a1hA-3pg7A:
undetectable
2a1hB-3pg7A:
undetectable		 2a1hA-3pg7A:
21.83
2a1hB-3pg7A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3pg7 NEUROFIBROMIN
(Homo
sapiens) 		5 / 12 ILE A1620
ALA A1655
GLN A1702
LEU A1705
VAL A1622
 PTY  A 400 (-3.8A)
None
None
None
None
 1.19A 3ix9A-3pg7A:
undetectable		 3ix9A-3pg7A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3pg7 NEUROFIBROMIN
(Homo
sapiens) 		4 / 7 PHE A1719
VAL A1736
ILE A1805
GLU A1794
 None
 1.08A 4a97E-3pg7A:
undetectable		 4a97E-3pg7A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3pg7 NEUROFIBROMIN
(Homo
sapiens) 		4 / 8 PHE A1719
VAL A1736
ILE A1805
GLU A1794
 None
 1.01A 4a97C-3pg7A:
undetectable		 4a97C-3pg7A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3pg7 NEUROFIBROMIN
(Homo
sapiens) 		4 / 8 PHE A1719
VAL A1736
ILE A1805
GLU A1794
 None
 1.06A 4a97G-3pg7A:
undetectable		 4a97G-3pg7A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 3pg7 NEUROFIBROMIN
(Homo
sapiens) 		4 / 8 ILE A1805
ILE A1769
LEU A1779
ILE A1766
 None
 0.94A 4dtaB-3pg7A:
undetectable		 4dtaB-3pg7A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 3pg7 NEUROFIBROMIN
(Homo
sapiens) 		4 / 5 SER A1745
ARG A1748
LEU A1757
ASP A1759
 None
 1.49A 4ifxA-3pg7A:
undetectable		 4ifxA-3pg7A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 3pg7 NEUROFIBROMIN
(Homo
sapiens) 		4 / 5 SER A1745
ARG A1748
LEU A1757
ASP A1759
 None
 1.50A 4ig1A-3pg7A:
undetectable		 4ig1A-3pg7A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3pg7 NEUROFIBROMIN
(Homo
sapiens) 		4 / 9 ILE A1658
VAL A1665
THR A1627
ASP A1623
 PTY  A 400 ( 4.8A)
None
None
None
 0.91A 5lg3I-3pg7A:
undetectable		 5lg3I-3pg7A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 3pg7 NEUROFIBROMIN
(Homo
sapiens) 		3 / 3 THR A1709
THR A1625
ARG A1590
 None
 0.82A 5wm2A-3pg7A:
undetectable		 5wm2A-3pg7A:
19.21