SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pg8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3pg8 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Thermotoga
maritima) 		4 / 5 ILE A  83
LEU A  85
VAL A 124
ALA A 114
 None
 0.96A 1mz9C-3pg8A:
undetectable		 1mz9C-3pg8A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3pg8 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Thermotoga
maritima) 		5 / 12 VAL A 290
ILE A 266
VAL A 268
LEU A 250
PHE A 217
 None
 1.10A 2jn3A-3pg8A:
undetectable		 2jn3A-3pg8A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3pg8 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Thermotoga
maritima) 		4 / 7 ILE A 183
ARG A 208
ALA A 254
ILE A 258
 None
 0.85A 2xkwA-3pg8A:
undetectable		 2xkwA-3pg8A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 3pg8 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Thermotoga
maritima) 		4 / 7 ARG A 276
ASN A 248
GLY A 238
ASP A 251
 None
 0.93A 2y05A-3pg8A:
undetectable
2y05B-3pg8A:
undetectable		 2y05A-3pg8A:
24.42
2y05B-3pg8A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3pg8 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Thermotoga
maritima) 		5 / 9 ALA A 292
PHE A  95
LEU A 205
VAL A 162
ILE A 233
 None
 1.30A 3claA-3pg8A:
undetectable		 3claA-3pg8A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 3pg8 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Thermotoga
maritima) 		3 / 3 ILE A 181
SER A 199
SER A 195
 None
AZI  A   6 (-2.8A)
None
 0.61A 3iltH-3pg8A:
undetectable		 3iltH-3pg8A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3pg8 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Thermotoga
maritima) 		3 / 3 ASP A 269
ASN A 248
SER A 313
 None
 0.75A 4obwA-3pg8A:
undetectable		 4obwA-3pg8A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3pg8 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Thermotoga
maritima) 		6 / 12 VAL A 268
LEU A 329
VAL A 290
ALA A 286
SER A 284
LEU A 283
 None
 1.38A 4rrxA-3pg8A:
undetectable		 4rrxA-3pg8A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3pg8 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Thermotoga
maritima) 		4 / 4 GLY A 274
ARG A 237
ASN A 248
LEU A 250
 None
 1.18A 6b58A-3pg8A:
undetectable		 6b58A-3pg8A:
21.45