SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pgl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3pgl CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1
(Homo
sapiens) 		4 / 8 SER A 208
ASN A 187
ASN A 207
ASP A  96
 None
None
MG  A   1 (-2.7A)
MG  A   1 (-2.5A)
 1.01A 1p6kB-3pglA:
undetectable		 1p6kB-3pglA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3pgl CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1
(Homo
sapiens) 		4 / 8 SER A 208
ASN A 187
ASN A 207
ASP A  96
 None
None
MG  A   1 (-2.7A)
MG  A   1 (-2.5A)
 1.04A 1rs6A-3pglA:
undetectable		 1rs6A-3pglA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3pgl CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1
(Homo
sapiens) 		4 / 8 SER A 208
ASN A 187
ASN A 207
ASP A  96
 None
None
MG  A   1 (-2.7A)
MG  A   1 (-2.5A)
 1.02A 1rs6B-3pglA:
undetectable		 1rs6B-3pglA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 3pgl CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1
(Homo
sapiens) 		4 / 4 LEU A 150
SER A 154
LEU A 166
LEU A 101
 None
RZX  A 257 ( 3.8A)
None
None
 1.09A 1yajA-3pglA:
1.6		 1yajA-3pglA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3pgl CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1
(Homo
sapiens) 		4 / 8 SER A 208
ASN A 187
ASN A 207
ASP A  96
 None
None
MG  A   1 (-2.7A)
MG  A   1 (-2.5A)
 1.00A 1zzqA-3pglA:
undetectable		 1zzqA-3pglA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3pgl CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1
(Homo
sapiens) 		4 / 8 SER A 208
ASN A 187
ASN A 207
ASP A  96
 None
None
MG  A   1 (-2.7A)
MG  A   1 (-2.5A)
 0.98A 1zzqB-3pglA:
undetectable		 1zzqB-3pglA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3pgl CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1
(Homo
sapiens) 		4 / 8 SER A 208
ASN A 187
ASN A 207
ASP A  96
 None
None
MG  A   1 (-2.7A)
MG  A   1 (-2.5A)
 0.99A 1zzuA-3pglA:
undetectable		 1zzuA-3pglA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3pgl CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1
(Homo
sapiens) 		4 / 8 SER A 208
ASN A 187
ASN A 207
ASP A  96
 None
None
MG  A   1 (-2.7A)
MG  A   1 (-2.5A)
 1.00A 1zzuB-3pglA:
undetectable		 1zzuB-3pglA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 3pgl CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1
(Homo
sapiens) 		4 / 5 LEU A 139
GLY A 170
GLU A 144
CYH A 148
 None
 1.06A 3aiaA-3pglA:
undetectable
3aiaB-3pglA:
undetectable		 3aiaA-3pglA:
21.88
3aiaB-3pglA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3pgl CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1
(Homo
sapiens) 		5 / 11 PRO A 209
ASP A 206
LEU A 205
PHE A 226
THR A 100
 None
MG  A   1 ( 4.4A)
None
None
None
 1.42A 3n23C-3pglA:
8.2		 3n23C-3pglA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 3pgl CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1
(Homo
sapiens) 		4 / 8 SER A 208
ASN A 187
ASN A 207
ASP A  96
 None
None
MG  A   1 (-2.7A)
MG  A   1 (-2.5A)
 1.02A 3n66B-3pglA:
undetectable		 3n66B-3pglA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3pgl CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1
(Homo
sapiens) 		4 / 7 SER A 208
ASN A 187
ASN A 207
ASP A  96
 None
None
MG  A   1 (-2.7A)
MG  A   1 (-2.5A)
 1.10A 4d33B-3pglA:
undetectable		 4d33B-3pglA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3pgl CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1
(Homo
sapiens) 		4 / 8 SER A 208
ASN A 187
ASN A 207
ASP A  96
 None
None
MG  A   1 (-2.7A)
MG  A   1 (-2.5A)
 1.00A 4d39A-3pglA:
undetectable		 4d39A-3pglA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3pgl CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1
(Homo
sapiens) 		4 / 7 SER A 208
ASN A 187
ASN A 207
ASP A  96
 None
None
MG  A   1 (-2.7A)
MG  A   1 (-2.5A)
 1.05A 4d39B-3pglA:
undetectable		 4d39B-3pglA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 3pgl CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1
(Homo
sapiens) 		4 / 7 ASP A  87
GLU A 147
PRO A  81
VAL A 149
 None
 1.07A 4hvrA-3pglA:
undetectable		 4hvrA-3pglA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3pgl CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1
(Homo
sapiens) 		4 / 6 PHE A 151
SER A 154
ALA A 153
LEU A  97
 None
RZX  A 257 ( 3.8A)
RZX  A 257 ( 4.9A)
None
 1.19A 5dzkB-3pglA:
undetectable
5dzkP-3pglA:
undetectable		 5dzkB-3pglA:
21.93
5dzkP-3pglA:
2.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3pgl CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1
(Homo
sapiens) 		4 / 7 PHE A 151
SER A 154
ALA A 153
LEU A  97
 None
RZX  A 257 ( 3.8A)
RZX  A 257 ( 4.9A)
None
 1.10A 5dzkD-3pglA:
undetectable
5dzkR-3pglA:
undetectable		 5dzkD-3pglA:
21.93
5dzkR-3pglA:
2.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3pgl CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1
(Homo
sapiens) 		4 / 8 SER A 208
ASN A 187
ASN A 207
ASP A  96
 None
None
MG  A   1 (-2.7A)
MG  A   1 (-2.5A)
 1.07A 5vunA-3pglA:
undetectable		 5vunA-3pglA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3pgl CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1
(Homo
sapiens) 		4 / 8 SER A 208
ASN A 187
ASN A 207
ASP A  96
 None
None
MG  A   1 (-2.7A)
MG  A   1 (-2.5A)
 1.02A 5vunB-3pglA:
undetectable		 5vunB-3pglA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3pgl CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1
(Homo
sapiens) 		4 / 8 SER A 208
ASN A 187
ASN A 207
ASP A  96
 None
None
MG  A   1 (-2.7A)
MG  A   1 (-2.5A)
 1.03A 5vuoB-3pglA:
undetectable		 5vuoB-3pglA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3pgl CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1
(Homo
sapiens) 		4 / 8 SER A 208
ASN A 187
ASN A 207
ASP A  96
 None
None
MG  A   1 (-2.7A)
MG  A   1 (-2.5A)
 0.98A 6auuB-3pglA:
undetectable		 6auuB-3pglA:
21.07