SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ph3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 3ph3 RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A  61
ARG A  60
GLY A  46
ALA A  75
ILE A  81
 None
 0.94A 1bx4A-3ph3A:
undetectable		 1bx4A-3ph3A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 3ph3 RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ASP A  41
GLY A  70
ILE A  73
ALA A  50
 None
RB5  A 150 (-3.5A)
None
None
 0.67A 1n49A-3ph3A:
undetectable		 1n49A-3ph3A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 3ph3 RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A  33
ILE A  18
ILE A  62
GLY A   4
ILE A  30
 None
 0.89A 1sguB-3ph3A:
undetectable		 1sguB-3ph3A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 3ph3 RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 GLY A  33
ILE A  18
ILE A  62
GLY A   4
ILE A  30
 None
 1.06A 1sh9B-3ph3A:
undetectable		 1sh9B-3ph3A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 3ph3 RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 LEU A 124
ILE A  18
GLY A  61
CYH A  58
 None
 0.80A 1sv9A-3ph3A:
undetectable		 1sv9A-3ph3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 3ph3 RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		4 / 6 LEU A  14
LEU A 106
LEU A 115
LEU A 117
 None
 1.02A 2ab2A-3ph3A:
undetectable		 2ab2A-3ph3A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 3ph3 RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		4 / 5 LEU A  14
LEU A 106
LEU A 115
LEU A 117
 None
 1.05A 2ab2B-3ph3A:
undetectable		 2ab2B-3ph3A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 3ph3 RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A  33
ILE A  18
ILE A  62
GLY A   4
ILE A  30
 None
 1.00A 2hs1A-3ph3A:
undetectable		 2hs1A-3ph3A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 3ph3 RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ASP A   8
GLY A  66
TYR A  42
 RB5  A 150 (-2.8A)
RB5  A 150 (-3.7A)
RB5  A 150 (-4.1A)
 0.80A 3w9tC-3ph3A:
undetectable		 3w9tC-3ph3A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 3ph3 RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ASP A   8
GLY A  66
TYR A  42
 RB5  A 150 (-2.8A)
RB5  A 150 (-3.7A)
RB5  A 150 (-4.1A)
 0.80A 3w9tG-3ph3A:
undetectable		 3w9tG-3ph3A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 3ph3 RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		5 / 7 ALA A  52
GLY A   6
ILE A  62
GLY A  61
ILE A 103
 None
 0.78A 4eatA-3ph3A:
2.5		 4eatA-3ph3A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 3ph3 RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		5 / 9 ALA A  52
GLY A   6
ILE A  62
GLY A  61
ILE A 103
 None
 0.77A 4eatB-3ph3A:
2.5		 4eatB-3ph3A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 3ph3 RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ILE A 103
LYS A  15
ILE A   5
GLY A 107
 None
 0.96A 4hdlA-3ph3A:
undetectable		 4hdlA-3ph3A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 3ph3 RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		5 / 11 GLY A  33
ILE A  18
ILE A  62
GLY A   4
ILE A  30
 None
 0.93A 4q1xA-3ph3A:
undetectable		 4q1xA-3ph3A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 3ph3 RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A  61
ARG A  60
GLY A  46
ALA A  75
ILE A  81
 None
 0.91A 5kb6B-3ph3A:
undetectable		 5kb6B-3ph3A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 3ph3 RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		6 / 12 GLY A 107
GLY A  66
LEU A  69
VAL A  85
ALA A 105
LEU A 106
 None
RB5  A 150 (-3.7A)
None
None
None
None
 1.36A 5kpcA-3ph3A:
undetectable		 5kpcA-3ph3A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 3ph3 RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 117
ALA A 116
LEU A  14
ILE A   3
LEU A 104
 None
 1.02A 5toaA-3ph3A:
undetectable		 5toaA-3ph3A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 3ph3 RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 PHE A  21
ASP A  20
LYS A  24
 None
 0.85A 6awtD-3ph3A:
undetectable		 6awtD-3ph3A:
21.26