SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3phf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		4 / 5 LEU A 466
SER A 518
LEU A 519
GLY A 512
 None
 1.15A 1a4lB-3phfA:
undetectable		 1a4lB-3phfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		3 / 3 ALA A  94
VAL A 313
TRP A 317
 None
 0.70A 1c4dA-3phfA:
undetectable
1c4dB-3phfA:
undetectable		 1c4dA-3phfA:
2.37
1c4dB-3phfA:
2.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		3 / 3 TRP A 317
ALA A  94
VAL A 313
 None
 0.66A 1c4dA-3phfA:
undetectable
1c4dB-3phfA:
undetectable		 1c4dA-3phfA:
2.37
1c4dB-3phfA:
2.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		3 / 3 ALA A  94
VAL A 313
TRP A 317
 None
 0.81A 1c4dC-3phfA:
undetectable
1c4dD-3phfA:
undetectable		 1c4dC-3phfA:
2.37
1c4dD-3phfA:
2.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		3 / 3 MET A 361
LEU A 364
SER A 398
 None
 0.57A 1ee2A-3phfA:
undetectable		 1ee2A-3phfA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		3 / 3 LEU A 351
LEU A 348
SER A 345
 None
 0.64A 1tlmA-3phfA:
undetectable		 1tlmA-3phfA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		6 / 12 PHE A 322
GLY A 302
THR A 308
GLY A 347
LEU A 348
LEU A 351
 None
 1.40A 2hw2A-3phfA:
undetectable		 2hw2A-3phfA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		4 / 6 LEU A 351
MET A 121
LEU A 318
GLU A 349
 None
 1.21A 2kuhA-3phfA:
undetectable		 2kuhA-3phfA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		3 / 3 TYR A 261
GLU A 293
ASN A 245
 None
 1.01A 2y7hC-3phfA:
1.0		 2y7hC-3phfA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3phf ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L
(Human
gammaherpesvirus
4) 		4 / 7 PHE B  89
LEU A  25
LEU A  27
LEU B  50
 None
 0.83A 3bgdB-3phfB:
undetectable		 3bgdB-3phfB:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		3 / 3 THR A 181
SER A 195
PHE A 177
 None
 0.89A 3d4sA-3phfA:
undetectable		 3d4sA-3phfA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3phf ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L
(Human
gammaherpesvirus
4;
Human
gammaherpesvirus
4) 		3 / 3 ASN B 127
MET A  68
PHE B  59
 None
 1.08A 3g4lD-3phfB:
undetectable		 3g4lD-3phfB:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		4 / 6 ILE A 599
VAL A 667
LEU A 661
LEU A 620
 None
 0.93A 3kp6A-3phfA:
undetectable
3kp6B-3phfA:
undetectable		 3kp6A-3phfA:
12.34
3kp6B-3phfA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		4 / 7 LEU A 318
GLY A 302
GLU A 127
ALA A 304
 None
 0.83A 3tehB-3phfA:
undetectable		 3tehB-3phfA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		4 / 7 ASN A 585
ALA A 531
PRO A 530
ALA A 444
 None
 1.04A 3twpA-3phfA:
undetectable		 3twpA-3phfA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		4 / 7 ASN A 585
ALA A 531
PRO A 530
ALA A 444
 None
 1.07A 3twpB-3phfA:
2.7		 3twpB-3phfA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		4 / 7 ASN A 585
ALA A 531
PRO A 530
ALA A 444
 None
 1.07A 3twpC-3phfA:
undetectable		 3twpC-3phfA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		4 / 5 ALA A 531
PRO A 530
TYR A 532
ALA A 526
 None
 1.40A 3twpD-3phfA:
undetectable		 3twpD-3phfA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		4 / 5 ASN A 585
ALA A 531
PRO A 530
ALA A 444
 None
 1.03A 3twpD-3phfA:
undetectable		 3twpD-3phfA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		5 / 10 LEU A  74
ARG A 208
GLU A  63
PRO A 210
PHE A 211
 None
 1.31A 3ua5B-3phfA:
0.6		 3ua5B-3phfA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		3 / 3 SER A  51
ASP A 206
ASP A 203
 None
 0.82A 3uj7A-3phfA:
undetectable		 3uj7A-3phfA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		5 / 12 SER A 195
LEU A 194
PHE A 148
ILE A  75
LEU A 216
 None
 1.13A 3w68A-3phfA:
undetectable		 3w68A-3phfA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		4 / 7 LEU A 351
ALA A 104
LEU A 348
SER A 345
 None
 0.92A 4d7bA-3phfA:
undetectable		 4d7bA-3phfA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		4 / 8 GLY A 391
LEU A 392
ILE A 393
THR A 438
 None
 0.85A 4em2A-3phfA:
undetectable		 4em2A-3phfA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		4 / 6 LEU A 351
ALA A 104
LEU A 348
SER A 345
 None
 0.90A 4ikiB-3phfA:
undetectable		 4ikiB-3phfA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		4 / 7 LEU A 351
ALA A 104
LEU A 348
SER A 345
 None
 0.86A 4ikjA-3phfA:
undetectable
4ikjB-3phfA:
undetectable		 4ikjA-3phfA:
11.95
4ikjB-3phfA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		4 / 7 LEU A 351
ALA A 104
LEU A 348
SER A 345
 None
 0.88A 4ikkA-3phfA:
undetectable
4ikkB-3phfA:
undetectable		 4ikkA-3phfA:
11.95
4ikkB-3phfA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3phf ENVELOPE
GLYCOPROTEIN L
(Human
gammaherpesvirus
4) 		4 / 6 THR B  55
LEU B  83
LEU B 111
GLU B 112
 None
 1.25A 4nc3A-3phfB:
undetectable		 4nc3A-3phfB:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		4 / 8 LEU A 226
VAL A 296
VAL A 254
LEU A 196
 None
 1.05A 4q0bA-3phfA:
undetectable		 4q0bA-3phfA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 3phf ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L
(Human
gammaherpesvirus
4) 		3 / 3 VAL B 120
PHE A 211
ARG A  71
 None
 0.93A 4xr4B-3phfB:
undetectable		 4xr4B-3phfB:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		5 / 12 ILE A 112
GLY A 114
ARG A 350
MET A 354
LEU A 126
 None
 0.88A 5e72A-3phfA:
undetectable		 5e72A-3phfA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		4 / 7 ASN A 405
VAL A 639
SER A 636
GLY A 616
 None
 0.89A 5fpdB-3phfA:
undetectable		 5fpdB-3phfA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		4 / 6 GLY A 394
THR A 397
SER A 398
ASN A 442
 None
 0.80A 5k4pA-3phfA:
undetectable		 5k4pA-3phfA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		5 / 12 VAL A 462
GLU A 458
SER A 476
ARG A 488
LEU A 486
 None
 1.28A 5nd2B-3phfA:
undetectable		 5nd2B-3phfA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		5 / 12 SER A 195
VAL A 197
ALA A 172
TYR A 213
GLY A 180
 None
 1.19A 5tzoA-3phfA:
undetectable		 5tzoA-3phfA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		5 / 12 SER A 195
VAL A 197
ALA A 172
TYR A 213
GLY A 180
 None
 1.18A 5tzoC-3phfA:
undetectable		 5tzoC-3phfA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 3phf ENVELOPE
GLYCOPROTEIN L
(Human
gammaherpesvirus
4) 		3 / 3 ARG B  95
ILE B  92
SER B  91
 None
 0.84A 5zw2A-3phfB:
undetectable		 5zw2A-3phfB:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		4 / 8 THR A 326
VAL A 327
GLU A 324
SER A 321
 None
 1.08A 6fbvC-3phfA:
0.5		 6fbvC-3phfA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		3 / 3 THR A 551
ALA A 531
LYS A 533
 None
 0.61A 6fgcA-3phfA:
undetectable		 6fgcA-3phfA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 3phf ENVELOPE
GLYCOPROTEIN H
(Human
gammaherpesvirus
4) 		3 / 3 THR A 551
ALA A 531
LYS A 533
 None
 0.62A 6fgdA-3phfA:
undetectable		 6fgdA-3phfA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3phf ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L
(Human
gammaherpesvirus
4;
Human
gammaherpesvirus
4) 		4 / 4 ASP A 206
ILE B  92
PRO A  52
LEU A  55
 None
 1.13A 6mkeA-3phfA:
undetectable		 6mkeA-3phfA:
7.62