SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3phu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S53_A_017A201_2 (PROTEASE)	3phu	RNA-DIRECTED RNA POLYMERASE L (Crimean-Congo hemorrhagic fever orthonairovirus)	5 / 11	LEU A 144 ALA A 105 ILE A 131 GLY A 134 ILE A 118	None	1.18A	3s53B-3phuA: undetectable	3s53B-3phuA: 17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SNF_A_ACTA110_0 (PROTEIN P-30)	3phu	RNA-DIRECTED RNA POLYMERASE L (Crimean-Congo hemorrhagic fever orthonairovirus)	4 / 5	ILE A 118 THR A 102 SER A 101 PHE A 152	None	1.03A	3snfA-3phuA: undetectable	3snfA-3phuA: 16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G1B_B_ECNB403_1 (FLAVOHEMOGLOBIN)	3phu	RNA-DIRECTED RNA POLYMERASE L (Crimean-Congo hemorrhagic fever orthonairovirus)	5 / 11	ILE A 31 PHE A 29 LEU A 145 THR A 120 VAL A 121	None	0.97A	4g1bB-3phuA: undetectable	4g1bB-3phuA: 20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G1B_D_ECND403_1 (FLAVOHEMOGLOBIN)	3phu	RNA-DIRECTED RNA POLYMERASE L (Crimean-Congo hemorrhagic fever orthonairovirus)	5 / 12	ILE A 31 PHE A 29 LEU A 145 THR A 120 VAL A 121	None	0.96A	4g1bD-3phuA: undetectable	4g1bD-3phuA: 20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NFJ_B_SAMB501_0 (MITOCHONDRIAL RIBONUCLEASE P PROTEIN 1)	3phu	RNA-DIRECTED RNA POLYMERASE L (Crimean-Congo hemorrhagic fever orthonairovirus)	5 / 12	ALA A 141 ILE A 131 GLY A 130 ASN A 143 LEU A 144	None	1.02A	5nfjB-3phuA: undetectable	5nfjB-3phuA: 21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NFJ_C_SAMC501_0 (MITOCHONDRIAL RIBONUCLEASE P PROTEIN 1)	3phu	RNA-DIRECTED RNA POLYMERASE L (Crimean-Congo hemorrhagic fever orthonairovirus)	5 / 12	ALA A 141 ILE A 131 GLY A 130 ASN A 143 LEU A 144	None	1.00A	5nfjC-3phuA: undetectable	5nfjC-3phuA: 21.01

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3S53_A_017A201_2","PROTEASE;PROTEASE","3phu","RNA-DIRECTED RNA POLYMERASE L","Crimean-Congo hemorrhagic fever orthonairovirus",5,"LEU A 144;ALA A 105;ILE A 131;GLY A 134;ILE A 118","None","1.18A","3s53B-3phuA:undetectable","3s53B-3phuA:17.14"],["3SNF_A_ACTA110_0","PROTEIN P-30","3phu","RNA-DIRECTED RNA POLYMERASE L","Crimean-Congo hemorrhagic fever orthonairovirus",4,"ILE A 118;THR A 102;SER A 101;PHE A 152","None","1.03A","3snfA-3phuA:undetectable","3snfA-3phuA:16.74"],["4G1B_B_ECNB403_1","FLAVOHEMOGLOBIN","3phu","RNA-DIRECTED RNA POLYMERASE L","Crimean-Congo hemorrhagic fever orthonairovirus",5,"ILE A  31;PHE A  29;LEU A 145;THR A 120;VAL A 121","None","0.97A","4g1bB-3phuA:undetectable","4g1bB-3phuA:20.20"],["4G1B_D_ECND403_1","FLAVOHEMOGLOBIN","3phu","RNA-DIRECTED RNA POLYMERASE L","Crimean-Congo hemorrhagic fever orthonairovirus",5,"ILE A  31;PHE A  29;LEU A 145;THR A 120;VAL A 121","None","0.96A","4g1bD-3phuA:undetectable","4g1bD-3phuA:20.20"],["5NFJ_B_SAMB501_0","MITOCHONDRIAL RIBONUCLEASE P PROTEIN 1","3phu","RNA-DIRECTED RNA POLYMERASE L","Crimean-Congo hemorrhagic fever orthonairovirus",5,"ALA A 141;ILE A 131;GLY A 130;ASN A 143;LEU A 144","None","1.02A","5nfjB-3phuA:undetectable","5nfjB-3phuA:21.01"],["5NFJ_C_SAMC501_0","MITOCHONDRIAL RIBONUCLEASE P PROTEIN 1","3phu","RNA-DIRECTED RNA POLYMERASE L","Crimean-Congo hemorrhagic fever orthonairovirus",5,"ALA A 141;ILE A 131;GLY A 130;ASN A 143;LEU A 144","None","1.00A","5nfjC-3phuA:undetectable","5nfjC-3phuA:21.01"]]