SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pic'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 3pic CIP2
(Trichoderma
reesei) 		4 / 6 ASN A 215
VAL A 252
GLY A 251
ALA A 287
 None
 0.76A 1e7bB-3picA:
undetectable		 1e7bB-3picA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 3pic CIP2
(Trichoderma
reesei) 		3 / 3 THR A 297
THR A 275
PRO A 299
 None
 0.85A 1fjaC-3picA:
undetectable		 1fjaC-3picA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 3pic CIP2
(Trichoderma
reesei) 		3 / 3 THR A 297
THR A 275
PRO A 299
 None
 0.85A 1fjaD-3picA:
undetectable		 1fjaD-3picA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 3pic CIP2
(Trichoderma
reesei) 		5 / 12 PRO A 348
ILE A 452
ALA A 109
SER A 380
ASN A 112
 None
 1.13A 1sg9C-3picA:
undetectable		 1sg9C-3picA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 3pic CIP2
(Trichoderma
reesei) 		3 / 3 THR A 297
THR A 275
PRO A 299
 None
 0.86A 1unmF-3picA:
undetectable		 1unmF-3picA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 3pic CIP2
(Trichoderma
reesei) 		3 / 3 THR A 297
THR A 275
PRO A 299
 None
 0.76A 209dC-3picA:
undetectable		 209dC-3picA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 3pic CIP2
(Trichoderma
reesei) 		4 / 8 HIS A 409
GLY A 407
PHE A 414
ILE A 406
 None
 1.05A 2a8tB-3picA:
undetectable		 2a8tB-3picA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3pic CIP2
(Trichoderma
reesei) 		5 / 12 ALA A 359
ALA A 358
LEU A 357
LEU A 114
ILE A 312
 None
 1.01A 2aclA-3picA:
undetectable
2aclE-3picA:
undetectable		 2aclA-3picA:
19.28
2aclE-3picA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 3pic CIP2
(Trichoderma
reesei) 		4 / 5 ALA A 304
TRP A 310
LEU A 357
ALA A 308
 None
 1.23A 2jstA-3picA:
undetectable
2jstB-3picA:
undetectable		 2jstA-3picA:
10.12
2jstB-3picA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3pic CIP2
(Trichoderma
reesei) 		5 / 11 ALA A 387
ALA A 388
VAL A 397
MET A 136
PHE A 115
 None
 1.24A 3bszE-3picA:
undetectable		 3bszE-3picA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 3pic CIP2
(Trichoderma
reesei) 		5 / 12 ALA A 304
GLY A 305
LEU A 376
SER A 302
SER A 313
 None
 1.41A 3bxoB-3picA:
undetectable		 3bxoB-3picA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3pic CIP2
(Trichoderma
reesei) 		5 / 12 ILE A 195
GLU A 260
PRO A 152
ARG A 293
TYR A 197
 None
 1.34A 3eigA-3picA:
undetectable		 3eigA-3picA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3pic CIP2
(Trichoderma
reesei) 		3 / 3 GLY A 288
PRO A 299
LEU A 366
 None
 0.63A 3hcpB-3picA:
undetectable		 3hcpB-3picA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3pic CIP2
(Trichoderma
reesei) 		4 / 7 ASP A 257
ILE A 294
VAL A 274
TYR A 197
 None
 1.06A 3p6hA-3picA:
undetectable		 3p6hA-3picA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 3pic CIP2
(Trichoderma
reesei) 		4 / 8 LEU A 296
THR A 269
ASP A 268
PHE A 429
 None
 1.04A 4drjB-3picA:
undetectable		 4drjB-3picA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3pic CIP2
(Trichoderma
reesei) 		5 / 12 GLY A 251
ALA A 249
ILE A 175
SER A 176
PRO A 152
 None
 1.14A 4rtpA-3picA:
undetectable		 4rtpA-3picA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3pic CIP2
(Trichoderma
reesei) 		5 / 12 GLY A 251
ILE A 175
SER A 176
ASP A 257
PRO A 152
 None
 1.20A 4rtpA-3picA:
undetectable		 4rtpA-3picA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3pic CIP2
(Trichoderma
reesei) 		4 / 4 GLY A 283
LEU A 202
PHE A 414
ILE A 369
 None
 0.98A 4xv2A-3picA:
undetectable		 4xv2A-3picA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3pic CIP2
(Trichoderma
reesei) 		5 / 10 LEU A 148
GLY A 251
VAL A 252
GLU A 291
THR A 246
 None
 1.32A 4yb6D-3picA:
undetectable
4yb6E-3picA:
undetectable		 4yb6D-3picA:
20.74
4yb6E-3picA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3pic CIP2
(Trichoderma
reesei) 		4 / 8 ILE A 195
PHE A 177
GLY A 251
LEU A 155
 None
 0.93A 5esjA-3picA:
undetectable		 5esjA-3picA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 3pic CIP2
(Trichoderma
reesei) 		5 / 12 PHE A 213
ILE A 195
PHE A 177
GLY A 251
LEU A 155
 None
 1.19A 5fsaA-3picA:
undetectable		 5fsaA-3picA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3pic CIP2
(Trichoderma
reesei) 		3 / 3 SER A 278
LEU A 357
MET A 285
 None
 0.85A 5ikrB-3picA:
undetectable		 5ikrB-3picA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 3pic CIP2
(Trichoderma
reesei) 		5 / 12 ILE A 103
PRO A 351
LEU A 105
SER A 356
PHE A 118
 None
 1.36A 5il1A-3picA:
undetectable		 5il1A-3picA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 3pic CIP2
(Trichoderma
reesei) 		4 / 6 SER A 313
GLY A 306
ILE A 329
TRP A 310
 None
 1.12A 5j4nA-3picA:
undetectable		 5j4nA-3picA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3pic CIP2
(Trichoderma
reesei) 		5 / 12 PHE A 213
ILE A 195
PHE A 177
GLY A 251
LEU A 155
 None
 1.25A 5v5zA-3picA:
undetectable		 5v5zA-3picA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 3pic CIP2
(Trichoderma
reesei) 		4 / 6 LEU A 422
PRO A 415
HIS A 409
GLU A 301
 None
 1.00A 6pahA-3picA:
undetectable		 6pahA-3picA:
19.90