SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pie'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		4 / 5 LEU A 223
LEU A 250
LEU A 278
GLY A 213
 None
 0.88A 1a4lC-3pieA:
undetectable		 1a4lC-3pieA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		4 / 7 LEU A 806
VAL A 827
TYR A 816
GLY A 818
 None
 0.94A 1lweA-3pieA:
undetectable		 1lweA-3pieA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		5 / 11 GLU A 370
ARG A  13
LEU A 750
LEU A 364
PRO A 307
 None
 1.40A 1mjqA-3pieA:
1.4
1mjqB-3pieA:
1.0		 1mjqA-3pieA:
7.44
1mjqB-3pieA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		5 / 9 LEU A 339
PHE A 335
GLY A 573
LEU A 293
LEU A 541
 None
 1.02A 1nr6A-3pieA:
undetectable		 1nr6A-3pieA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TH6_A_OINA401_1
(PHOSPHOLIPASE A2)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		4 / 7 GLY A1177
ASP A  69
PRO A  77
LYS A  76
 None
 1.12A 1th6A-3pieA:
undetectable		 1th6A-3pieA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		3 / 3 LEU A 209
LEU A 212
SER A 215
 None
 0.63A 1tlmA-3pieA:
undetectable		 1tlmA-3pieA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		3 / 3 TYR A 548
ARG A 100
GLN A  97
 None
 1.01A 1tw4A-3pieA:
undetectable		 1tw4A-3pieA:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		4 / 8 LEU A 143
PHE A  81
MET A  36
SER A  38
 None
 1.00A 1wrlC-3pieA:
undetectable
1wrlD-3pieA:
undetectable		 1wrlC-3pieA:
6.07
1wrlD-3pieA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		5 / 12 GLY A 937
GLY A 936
LEU A1233
SER A1234
LEU A1231
 None
 0.91A 1ya4A-3pieA:
undetectable		 1ya4A-3pieA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ARM_A_OINA401_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		4 / 7 GLY A1177
ASP A  69
PRO A  77
LYS A  76
 None
 1.12A 2armA-3pieA:
undetectable		 2armA-3pieA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		4 / 7 TYR A  61
GLU A 172
HIS A 171
GLY A 170
 None
 1.19A 2ha4B-3pieA:
undetectable		 2ha4B-3pieA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		4 / 5 ASP A 279
LEU A 724
GLY A 723
ARG A 254
 None
 1.14A 2j2pA-3pieA:
undetectable
2j2pB-3pieA:
undetectable		 2j2pA-3pieA:
11.25
2j2pB-3pieA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		4 / 5 SER A  56
LEU A 696
GLY A 695
ARG A1220
 None
 1.24A 2j2pA-3pieA:
undetectable
2j2pB-3pieA:
undetectable		 2j2pA-3pieA:
11.25
2j2pB-3pieA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		4 / 4 ASP A 279
LEU A 724
GLY A 723
ARG A 254
 None
 1.16A 2j2pD-3pieA:
undetectable
2j2pE-3pieA:
undetectable		 2j2pD-3pieA:
11.25
2j2pE-3pieA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		3 / 3 ASP A  30
ASN A  31
THR A 216
 None
 0.63A 2pymB-3pieA:
undetectable		 2pymB-3pieA:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		3 / 3 ARG A 566
SER A 568
TYR A 516
 None
 0.94A 2q2hA-3pieA:
undetectable
2q2hB-3pieA:
undetectable		 2q2hA-3pieA:
8.46
2q2hB-3pieA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		3 / 3 ASP A  30
ASN A  31
THR A 216
 None
 0.72A 2q63B-3pieA:
undetectable		 2q63B-3pieA:
6.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		5 / 12 ARG A 254
LEU A 735
PHE A 221
PRO A  27
ILE A 210
 None
 1.12A 2zzmA-3pieA:
2.8		 2zzmA-3pieA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		5 / 12 ARG A 254
LEU A 735
PHE A 221
PRO A  27
ILE A 210
 None
 1.20A 2zznA-3pieA:
3.0		 2zznA-3pieA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		4 / 6 THR A 814
THR A 811
SER A 783
LEU A 782
 None
 0.74A 3deuB-3pieA:
undetectable		 3deuB-3pieA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		4 / 8 TYR A 323
GLN A 311
GLU A 372
GLU A 263
 None
 1.38A 3dh0A-3pieA:
2.9		 3dh0A-3pieA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		3 / 3 MET A  36
MET A 182
PHE A 168
 None
 1.38A 3gn8A-3pieA:
undetectable		 3gn8A-3pieA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		4 / 7 GLU A 358
TRP A 359
LEU A 348
ASN A 349
 None
 1.29A 3k8mA-3pieA:
3.2		 3k8mA-3pieA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		4 / 7 GLU A 358
TRP A 359
LEU A 348
ASN A 349
 None
 1.31A 3k8mB-3pieA:
2.4		 3k8mB-3pieA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		4 / 8 GLN A  16
LEU A 744
LEU A 746
ILE A 771
 None
 0.72A 3nbqB-3pieA:
undetectable		 3nbqB-3pieA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		4 / 8 GLN A  16
LEU A 744
LEU A 746
ILE A 771
 None
 0.73A 3nbqC-3pieA:
undetectable		 3nbqC-3pieA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBR_A_ASDA129_1
(STEROID
DELTA-ISOMERASE)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		5 / 12 SER A1198
VAL A1187
PHE A1164
VAL A1170
PHE A1203
 None
 1.37A 3nbrA-3pieA:
0.0		 3nbrA-3pieA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_1
(PROTEASE)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		5 / 12 ARG A 960
ASP A1204
GLY A1185
GLY A 966
ILE A1126
 None
 1.00A 3ndwA-3pieA:
undetectable		 3ndwA-3pieA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_1
(PROTEASE)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		5 / 12 ARG A 960
ASP A1204
GLY A1185
GLY A 966
ILE A1126
 None
 1.00A 3ndxA-3pieA:
undetectable		 3ndxA-3pieA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_1
(HIV-1 PROTEASE)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		5 / 12 ARG A 960
ASP A1204
GLY A1185
GLY A 966
ILE A1126
 None
 1.06A 3oxxA-3pieA:
undetectable		 3oxxA-3pieA:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		4 / 7 LEU A 205
ASP A 206
ALA A 207
TYR A 203
 None
 1.15A 3rodD-3pieA:
undetectable		 3rodD-3pieA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		5 / 12 TYR A 559
GLY A 540
PHE A 292
HIS A 562
PHE A 646
 None
 1.42A 3s8pA-3pieA:
undetectable		 3s8pA-3pieA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		5 / 12 TYR A 559
GLY A 540
PHE A 292
HIS A 562
PHE A 646
 None
 1.41A 3s8pB-3pieA:
undetectable		 3s8pB-3pieA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		3 / 3 GLN A1138
GLU A 938
LYS A 955
 None
 0.91A 3su9A-3pieA:
undetectable		 3su9A-3pieA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		3 / 3 GLU A  58
GLY A 695
SER A  62
 None
 0.68A 4b53B-3pieA:
undetectable		 4b53B-3pieA:
6.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		5 / 12 TYR A 559
GLY A 540
PHE A 292
HIS A 562
PHE A 646
 None
 1.43A 4bupB-3pieA:
undetectable		 4bupB-3pieA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		4 / 7 ILE A 264
ARG A 375
MET A 767
TRP A  14
 None
 1.20A 4f4dA-3pieA:
undetectable		 4f4dA-3pieA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		4 / 8 ILE A 264
ARG A 375
MET A 767
TRP A  14
 None
 1.28A 4f4dB-3pieA:
3.2		 4f4dB-3pieA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		4 / 8 ASP A  22
ASP A 906
ASN A 887
GLU A 891
 None
 1.03A 4feuD-3pieA:
undetectable		 4feuD-3pieA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		4 / 8 SER A 925
LYS A1139
LEU A1141
LEU A 952
 None
 0.78A 4iklA-3pieA:
undetectable
4iklB-3pieA:
undetectable		 4iklA-3pieA:
9.35
4iklB-3pieA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		5 / 8 ALA A 864
PRO A 894
LEU A 809
TYR A 816
LEU A 782
 None
 1.50A 4jjkA-3pieA:
4.2		 4jjkA-3pieA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		3 / 3 TYR A 893
ARG A 802
SER A 796
 None
 1.11A 4khpI-3pieA:
undetectable
4khpJ-3pieA:
undetectable		 4khpI-3pieA:
9.71
4khpJ-3pieA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		3 / 3 ARG A 375
HIS A 319
SER A 267
 None
 0.84A 4mjwA-3pieA:
undetectable
4mjwB-3pieA:
undetectable		 4mjwA-3pieA:
17.72
4mjwB-3pieA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		3 / 3 SER A 267
ARG A 375
HIS A 319
 None
 0.84A 4mjwA-3pieA:
undetectable
4mjwB-3pieA:
undetectable		 4mjwA-3pieA:
17.72
4mjwB-3pieA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		3 / 3 ARG A 100
GLU A 176
ARG A 101
 None
 0.78A 4mwvA-3pieA:
undetectable		 4mwvA-3pieA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_B_ACTB201_0
(RETINOL-BINDING
PROTEIN 2)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		4 / 5 TYR A 203
GLU A 226
LEU A  71
GLN A 243
 None
 1.43A 4qztB-3pieA:
undetectable		 4qztB-3pieA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		4 / 4 SER A  38
ASP A  86
ASP A 183
ASP A 206
 None
 1.38A 4uciA-3pieA:
1.2		 4uciA-3pieA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		4 / 4 SER A  38
ASP A  86
ASP A 183
ASP A 206
 None
 1.36A 4uciB-3pieA:
1.3		 4uciB-3pieA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		5 / 12 LEU A 541
ILE A 330
ILE A 578
VAL A 570
LEU A 339
 None
 0.90A 4y0pA-3pieA:
undetectable		 4y0pA-3pieA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		5 / 12 LEU A 541
ILE A 330
ILE A 578
VAL A 570
LEU A 339
 None
 0.97A 4y0sA-3pieA:
undetectable		 4y0sA-3pieA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		4 / 6 LEU A 317
LEU A 310
ILE A 282
PHE A 281
 None
 1.11A 4y4dA-3pieA:
undetectable		 4y4dA-3pieA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		3 / 5 GLY A1222
GLY A1224
GLU A 241
 None
 0.48A 4z2eA-3pieA:
undetectable
4z2eD-3pieA:
undetectable		 4z2eA-3pieA:
18.92
4z2eD-3pieA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		4 / 5 TYR A 547
GLY A 177
TYR A 548
GLY A 213
 None
 0.90A 5ayfA-3pieA:
undetectable		 5ayfA-3pieA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		5 / 12 ASP A 129
ALA A 132
ASP A  86
SER A  38
SER A 130
 None
 1.23A 5hfjD-3pieA:
3.6		 5hfjD-3pieA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		3 / 3 VAL A1130
LEU A1114
MET A1119
 None
 0.72A 5ikrA-3pieA:
undetectable		 5ikrA-3pieA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M10_A_NCAA603_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		4 / 5 LEU A 257
PHE A   9
LEU A 285
TRP A  14
 None
 1.17A 5m10A-3pieA:
undetectable		 5m10A-3pieA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		5 / 12 ILE A 288
PHE A   6
LEU A 253
PHE A 221
ILE A  10
 None
 0.89A 5mueA-3pieA:
undetectable		 5mueA-3pieA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		5 / 10 TYR A  61
ILE A 202
LEU A 223
HIS A  41
ASN A  42
 None
 1.23A 5vkqA-3pieA:
2.0
5vkqD-3pieA:
2.1		 5vkqA-3pieA:
20.63
5vkqD-3pieA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		5 / 10 HIS A  41
ASN A  42
TYR A  61
ILE A 202
LEU A 223
 None
 1.25A 5vkqA-3pieA:
2.0
5vkqB-3pieA:
2.2		 5vkqA-3pieA:
20.63
5vkqB-3pieA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		5 / 10 HIS A  41
ASN A  42
TYR A  61
ILE A 202
LEU A 223
 None
 1.21A 5vkqC-3pieA:
2.2
5vkqD-3pieA:
2.1		 5vkqC-3pieA:
20.63
5vkqD-3pieA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		4 / 8 LEU A 147
LEU A 143
CYH A  43
ILE A  39
 None
 0.89A 5y1yA-3pieA:
undetectable		 5y1yA-3pieA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		3 / 3 TYR A 341
HIS A 319
MET A 320
 None
 0.93A 6af6A-3pieA:
undetectable		 6af6A-3pieA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		4 / 7 LEU A  20
PHE A 245
PHE A  29
LEU A 247
 None
 1.00A 6aycA-3pieA:
undetectable		 6aycA-3pieA:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		4 / 6 ILE A  85
MET A  36
ASN A  37
ASP A  35
 None
 1.36A 6dhbA-3pieA:
undetectable		 6dhbA-3pieA:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		4 / 6 TYR A 795
GLU A 803
ASP A 906
GLU A  28
 None
 1.07A 6mn5A-3pieA:
undetectable		 6mn5A-3pieA:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		4 / 7 TYR A 795
GLU A 803
ASP A 906
GLU A  28
 None
 1.01A 6mn5B-3pieA:
undetectable		 6mn5B-3pieA:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3pie 5'->3'
EXORIBONUCLEASE
(XRN1)
(Kluyveromyces
lactis) 		4 / 6 TYR A 795
GLU A 803
ASP A 906
GLU A  28
 None
 1.00A 6mn5C-3pieA:
undetectable		 6mn5C-3pieA:
5.60