SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pih'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		5 / 12 ALA A 588
GLU A 653
ILE A 652
LEU A 635
ILE A 607
 None
 0.99A 1d1gA-3pihA:
undetectable		 1d1gA-3pihA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		4 / 8 HIS A 876
ILE A 877
VAL A 627
SER A 621
 None
None
None
PPV  A1001 (-2.9A)
 1.15A 1kb9A-3pihA:
undetectable
1kb9C-3pihA:
undetectable
1kb9D-3pihA:
undetectable
1kb9E-3pihA:
undetectable		 1kb9A-3pihA:
20.24
1kb9C-3pihA:
18.10
1kb9D-3pihA:
13.32
1kb9E-3pihA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		5 / 12 ILE A  17
VAL A 489
LEU A  40
LEU A  79
ILE A  76
 None
 1.33A 1kqwA-3pihA:
undetectable		 1kqwA-3pihA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		4 / 4 HIS A 852
VAL A 855
THR A 582
LEU A 585
 None
 1.20A 1oq5A-3pihA:
undetectable		 1oq5A-3pihA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		5 / 12 LEU A 139
LEU A 136
ILE A 135
ILE A 132
LEU A 210
 None
 0.69A 1xdkB-3pihA:
undetectable		 1xdkB-3pihA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		5 / 12 LEU A 139
LEU A 136
ILE A 135
ILE A 132
LEU A 210
 None
 0.69A 1xdkF-3pihA:
undetectable		 1xdkF-3pihA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GEH_A_NHYA300_1
(CARBONIC ANHYDRASE 2)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		4 / 8 HIS A  12
VAL A 797
LEU A 806
THR A 805
 None
 0.91A 2gehA-3pihA:
undetectable		 2gehA-3pihA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		5 / 12 LEU A 880
VAL A 615
VAL A 613
ILE A 607
ILE A 592
 None
 1.15A 2gj5A-3pihA:
undetectable		 2gj5A-3pihA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		4 / 7 GLU A 454
PRO A 499
ARG A 500
GLY A 452
 None
 0.91A 2hs1B-3pihA:
undetectable		 2hs1B-3pihA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		5 / 12 VAL A 611
ILE A 658
TYR A 587
LEU A 631
ALA A 588
 None
 1.41A 2iyfB-3pihA:
undetectable		 2iyfB-3pihA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		4 / 6 SER A 466
SER A 619
LEU A 497
GLY A 496
 None
 0.97A 2j2pA-3pihA:
undetectable
2j2pC-3pihA:
undetectable		 2j2pA-3pihA:
12.57
2j2pC-3pihA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		4 / 4 LEU A 880
THR A 616
ILE A 607
HIS A 876
 None
 1.39A 2jfaB-3pihA:
undetectable		 2jfaB-3pihA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		5 / 11 GLY A 553
ILE A  29
ALA A  41
PRO A  22
ILE A   4
 None
 1.12A 2nnhA-3pihA:
undetectable		 2nnhA-3pihA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		4 / 7 ASN A  24
GLY A 516
THR A 484
SER A  80
 None
 1.00A 2o5yH-3pihA:
2.3
2o5yL-3pihA:
undetectable		 2o5yH-3pihA:
12.75
2o5yL-3pihA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		4 / 5 TYR A 112
ILE A 401
LEU A 438
LEU A 421
 None
 1.13A 2zb7A-3pihA:
undetectable		 2zb7A-3pihA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		3 / 3 ARG A 391
ASP A 106
ASN A 270
 None
 0.61A 2zzmA-3pihA:
undetectable		 2zzmA-3pihA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		4 / 4 SER A  33
GLY A  34
GLY A 838
GLY A 808
 PPV  A1002 (-3.1A)
PPV  A1002 (-3.1A)
PPV  A1002 (-4.2A)
PPV  A1002 ( 4.3A)
 0.82A 3bogB-3pihA:
undetectable
3bogD-3pihA:
undetectable		 3bogB-3pihA:
undetectable
3bogD-3pihA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		3 / 3 LEU A 732
GLU A 728
ILE A 727
 None
 0.48A 3czhA-3pihA:
undetectable		 3czhA-3pihA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		5 / 11 GLY A 881
GLY A 889
ILE A 864
SER A 619
VAL A 618
 None
 0.93A 3dcmX-3pihA:
undetectable		 3dcmX-3pihA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		5 / 12 LEU A  14
GLY A 543
VAL A 797
SER A  38
ILE A 669
 None
None
None
PPV  A1002 (-2.7A)
None
 0.98A 3frqB-3pihA:
undetectable		 3frqB-3pihA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		5 / 12 GLY A 909
GLY A 895
VAL A 605
ASP A 879
ILE A 891
 None
 1.00A 3gczA-3pihA:
2.2		 3gczA-3pihA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		4 / 6 TYR A 890
GLY A 888
LEU A 880
GLU A 887
 None
 1.01A 3ps9A-3pihA:
3.0		 3ps9A-3pihA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		4 / 6 TYR A 796
GLY A 542
HIS A  12
THR A 544
 None
 0.99A 3tj7A-3pihA:
undetectable
3tj7B-3pihA:
undetectable		 3tj7A-3pihA:
13.91
3tj7B-3pihA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		5 / 12 THR A 285
GLY A 283
ARG A 391
GLY A 388
GLU A 375
 None
 1.20A 3tkaA-3pihA:
undetectable		 3tkaA-3pihA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		5 / 12 GLN A 722
PHE A 709
GLY A 721
PRO A 673
ALA A 803
 None
 1.33A 3v3oB-3pihA:
undetectable		 3v3oB-3pihA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		5 / 12 VAL A 101
ASP A 106
THR A 457
ILE A 441
ILE A 406
 None
 1.24A 4eb6B-3pihA:
undetectable
4eb6C-3pihA:
undetectable		 4eb6B-3pihA:
19.98
4eb6C-3pihA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		3 / 3 ARG A 910
ASP A 501
ASP A 450
 None
 0.91A 4kicB-3pihA:
undetectable		 4kicB-3pihA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		5 / 11 VAL A 611
ILE A 658
TYR A 587
LEU A 631
ALA A 588
 None
 1.45A 4m83A-3pihA:
undetectable		 4m83A-3pihA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		4 / 8 GLU A 492
GLU A 834
GLU A 865
TYR A 570
 None
 1.19A 4mj8A-3pihA:
undetectable
4mj8C-3pihA:
undetectable		 4mj8A-3pihA:
12.46
4mj8C-3pihA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		4 / 6 VAL A 797
LEU A 794
LEU A 806
PHE A 709
 None
 0.86A 4o1zA-3pihA:
undetectable		 4o1zA-3pihA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		5 / 12 VAL A 797
LEU A 794
LEU A 806
PHE A 709
ALA A 678
 None
 0.93A 4o1zB-3pihA:
undetectable		 4o1zB-3pihA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		5 / 11 GLY A 714
PHE A 691
ILE A 687
TYR A 756
TYR A 702
 None
 1.37A 4rtrA-3pihA:
5.1		 4rtrA-3pihA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		4 / 6 TYR A 105
TYR A 112
LEU A 111
PHE A 409
 None
 1.38A 4twdF-3pihA:
undetectable
4twdG-3pihA:
undetectable		 4twdF-3pihA:
17.03
4twdG-3pihA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		5 / 11 LEU A 851
LEU A 847
LEU A 832
ALA A 817
LEU A 816
 None
 1.16A 4wg0B-3pihA:
undetectable
4wg0C-3pihA:
undetectable
4wg0D-3pihA:
undetectable		 4wg0B-3pihA:
1.64
4wg0C-3pihA:
1.64
4wg0D-3pihA:
1.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		5 / 11 LEU A 851
LEU A 847
LEU A 832
GLU A 819
LEU A 816
 None
 1.12A 4wg0B-3pihA:
undetectable
4wg0C-3pihA:
undetectable
4wg0D-3pihA:
undetectable		 4wg0B-3pihA:
1.64
4wg0C-3pihA:
1.64
4wg0D-3pihA:
1.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		5 / 11 LEU A 851
LEU A 847
LEU A 832
ALA A 817
LEU A 816
 None
 1.18A 4wg0D-3pihA:
undetectable
4wg0E-3pihA:
undetectable
4wg0F-3pihA:
undetectable		 4wg0D-3pihA:
1.64
4wg0E-3pihA:
1.64
4wg0F-3pihA:
1.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		5 / 11 LEU A 851
LEU A 847
LEU A 832
GLU A 819
LEU A 816
 None
 1.12A 4wg0D-3pihA:
undetectable
4wg0E-3pihA:
undetectable
4wg0F-3pihA:
undetectable		 4wg0D-3pihA:
1.64
4wg0E-3pihA:
1.64
4wg0F-3pihA:
1.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		6 / 11 GLU A 819
ALA A 817
LEU A 816
LEU A 832
LEU A 851
LEU A 847
 None
 1.29A 4wg0C-3pihA:
undetectable
4wg0D-3pihA:
undetectable
4wg0E-3pihA:
undetectable		 4wg0C-3pihA:
1.64
4wg0D-3pihA:
1.64
4wg0E-3pihA:
1.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		5 / 11 LEU A 851
LEU A 847
LEU A 832
GLU A 819
LEU A 816
 None
 1.12A 4wg0F-3pihA:
undetectable
4wg0G-3pihA:
undetectable
4wg0H-3pihA:
undetectable		 4wg0F-3pihA:
1.64
4wg0G-3pihA:
1.64
4wg0H-3pihA:
1.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		6 / 11 GLU A 819
ALA A 817
LEU A 816
LEU A 832
LEU A 851
LEU A 847
 None
 1.30A 4wg0E-3pihA:
undetectable
4wg0F-3pihA:
undetectable
4wg0G-3pihA:
undetectable		 4wg0E-3pihA:
1.64
4wg0F-3pihA:
1.64
4wg0G-3pihA:
1.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		5 / 11 GLU A 819
LEU A 816
LEU A 832
LEU A 851
LEU A 847
 None
 1.17A 4wg0G-3pihA:
undetectable
4wg0H-3pihA:
undetectable
4wg0I-3pihA:
undetectable		 4wg0G-3pihA:
1.64
4wg0H-3pihA:
1.64
4wg0I-3pihA:
1.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		3 / 3 SER A 466
GLU A 865
GLU A 526
 None
 0.62A 4ymgB-3pihA:
undetectable		 4ymgB-3pihA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		3 / 3 SER A 621
GLU A 865
GLU A 526
 PPV  A1001 (-2.9A)
None
None
 0.87A 4ymgB-3pihA:
undetectable		 4ymgB-3pihA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		5 / 12 GLY A 884
ASN A 599
GLY A 452
GLY A 622
HIS A 866
 None
None
None
PPV  A1001 (-3.4A)
None
 1.21A 5hikA-3pihA:
2.5		 5hikA-3pihA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		4 / 7 LEU A 152
SER A 221
ILE A 209
ASN A 237
 None
 1.02A 5n5dA-3pihA:
undetectable		 5n5dA-3pihA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		3 / 3 THR A 894
PRO A 586
ARG A 584
 None
 0.83A 5nd7B-3pihA:
undetectable		 5nd7B-3pihA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		4 / 6 GLY A 647
THR A 630
GLU A 629
SER A 625
 None
None
None
PPV  A1001 ( 4.2A)
 1.13A 5ny7A-3pihA:
undetectable		 5ny7A-3pihA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		4 / 8 THR A 836
GLN A 812
GLY A 468
ARG A 472
 None
 0.86A 5nzyA-3pihA:
undetectable		 5nzyA-3pihA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		4 / 8 HIS A  12
VAL A 797
LEU A 806
THR A 805
 None
 0.89A 5tt3H-3pihA:
undetectable		 5tt3H-3pihA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		4 / 6 ILE A 209
ILE A 135
LEU A 136
PHE A 140
 None
 1.06A 5vkqA-3pihA:
undetectable
5vkqB-3pihA:
undetectable		 5vkqA-3pihA:
18.76
5vkqB-3pihA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		4 / 6 ILE A 209
ILE A 135
LEU A 136
PHE A 140
 None
 1.04A 5vkqB-3pihA:
undetectable
5vkqC-3pihA:
undetectable		 5vkqB-3pihA:
18.76
5vkqC-3pihA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		4 / 6 ILE A 209
ILE A 135
LEU A 136
PHE A 140
 None
 1.04A 5vkqC-3pihA:
undetectable
5vkqD-3pihA:
undetectable		 5vkqC-3pihA:
18.76
5vkqD-3pihA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		4 / 6 ILE A 209
ILE A 135
LEU A 136
PHE A 140
 None
 1.04A 5vkqA-3pihA:
undetectable
5vkqD-3pihA:
undetectable		 5vkqA-3pihA:
18.76
5vkqD-3pihA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		4 / 6 LEU A  26
ALA A 532
LEU A 505
THR A 494
 None
 0.92A 6f88B-3pihA:
undetectable		 6f88B-3pihA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 3pih UVRABC SYSTEM
PROTEIN A
(Thermotoga
maritima) 		3 / 3 ARG A 715
PHE A 709
GLY A 721
 None
 0.63A 6fgdA-3pihA:
undetectable		 6fgdA-3pihA:
19.02