SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3piq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3piq HUMAN MONOCLONAL
ANTIBODY 2909 FAB
HEAVY CHAIN
(Homo
sapiens) 		4 / 7 TYR H 100
TYR H 100
GLY H  97
ASP H  95
 None
 1.08A 2g70B-3piqH:
undetectable		 2g70B-3piqH:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3piq HUMAN MONOCLONAL
ANTIBODY 2909 FAB
HEAVY CHAIN
(Homo
sapiens) 		4 / 6 TYR H 100
TYR H 100
GLY H  97
ASP H  95
 None
 1.13A 2g72A-3piqH:
undetectable		 2g72A-3piqH:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3piq HUMAN MONOCLONAL
ANTIBODY 2909 FAB
HEAVY CHAIN
(Homo
sapiens) 		4 / 7 TYR H 100
TYR H 100
GLY H  97
ASP H  95
 None
 1.10A 2g72B-3piqH:
undetectable		 2g72B-3piqH:
21.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 3piq HUMAN MONOCLONAL
ANTIBODY 2909 FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 11 VAL H   2
ALA H  24
MET H  34
ARG H  71
ASN H  73
 None
 0.80A 3qxvC-3piqH:
19.6		 3qxvC-3piqH:
56.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 3piq HUMAN MONOCLONAL
ANTIBODY 2909 FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 10 THR H 165
LEU H 124
GLY H 139
VAL H 198
VAL H 152
 None
 1.34A 4c9pB-3piqH:
undetectable		 4c9pB-3piqH:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 3piq HUMAN MONOCLONAL
ANTIBODY 2909 FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL H 207
THR H 205
VAL H 211
GLY H 118
VAL H 152
 None
 1.08A 6drzA-3piqH:
undetectable		 6drzA-3piqH:
19.23