SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3piw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Z9H_A_IMNA379_1 (MEMBRANE-ASSOCIATED PROSTAGLANDIN E SYNTHASE-2)	3piw	TYPE I INTERFERON 2 (Danio rerio)	5 / 12	TYR A 124 VAL A 13 ILE A 67 VAL A 60 LEU A 95	None	1.40A	1z9hA-3piwA: undetectable	1z9hA-3piwA: 20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Z9H_B_IMNB381_1 (MEMBRANE-ASSOCIATED PROSTAGLANDIN E SYNTHASE-2)	3piw	TYPE I INTERFERON 2 (Danio rerio)	5 / 12	TYR A 124 VAL A 13 ILE A 67 VAL A 60 LEU A 95	None	1.41A	1z9hB-3piwA: undetectable	1z9hB-3piwA: 20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Z9H_C_IMNC379_1 (MEMBRANE-ASSOCIATED PROSTAGLANDIN E SYNTHASE-2)	3piw	TYPE I INTERFERON 2 (Danio rerio)	5 / 12	TYR A 124 VAL A 13 ILE A 67 VAL A 60 LEU A 95	None	1.40A	1z9hC-3piwA: undetectable	1z9hC-3piwA: 20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W1W_A_CHDA1503_0 (FERROCHELATASE, MITOCHONDRIAL)	3piw	TYPE I INTERFERON 2 (Danio rerio)	4 / 8	ILE A 38 LEU A 128 VAL A 152 GLY A 151	None	0.85A	3w1wA-3piwA: undetectable	3w1wA-3piwA: 16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WZE_A_BAXA1201_2 (VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2)	3piw	TYPE I INTERFERON 2 (Danio rerio)	4 / 8	VAL A 144 VAL A 145 LEU A 149 PHE A 125	None	0.60A	3wzeA-3piwA: undetectable	3wzeA-3piwA: 19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4X1F_A_3WFA501_1 (NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2)	3piw	TYPE I INTERFERON 2 (Danio rerio)	5 / 12	ASP A 155 LEU A 45 PHE A 71 LEU A 153 ILE A 156	None	1.06A	4x1fA-3piwA: undetectable	4x1fA-3piwA: 20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4X1G_A_3WFA501_1 (NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2)	3piw	TYPE I INTERFERON 2 (Danio rerio)	5 / 12	ASP A 155 LEU A 45 PHE A 71 LEU A 153 ILE A 156	None	1.05A	4x1gA-3piwA: undetectable	4x1gA-3piwA: 20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NKN_A_LOCA201_2 (NEUTROPHIL GELATINASE-ASSOCIATE D LIPOCALIN)	3piw	TYPE I INTERFERON 2 (Danio rerio)	3 / 3	VAL A 92 LYS A 100 MET A 103	None	0.88A	5nknA-3piwA: undetectable	5nknA-3piwA: 23.44

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1Z9H_A_IMNA379_1","MEMBRANE-ASSOCIATED PROSTAGLANDIN E SYNTHASE-2","3piw","TYPE I INTERFERON 2","Danio rerio",5,"TYR A 124;VAL A  13;ILE A  67;VAL A  60;LEU A  95","None","1.40A","1z9hA-3piwA:undetectable","1z9hA-3piwA:20.22"],["1Z9H_B_IMNB381_1","MEMBRANE-ASSOCIATED PROSTAGLANDIN E SYNTHASE-2","3piw","TYPE I INTERFERON 2","Danio rerio",5,"TYR A 124;VAL A  13;ILE A  67;VAL A  60;LEU A  95","None","1.41A","1z9hB-3piwA:undetectable","1z9hB-3piwA:20.22"],["1Z9H_C_IMNC379_1","MEMBRANE-ASSOCIATED PROSTAGLANDIN E SYNTHASE-2","3piw","TYPE I INTERFERON 2","Danio rerio",5,"TYR A 124;VAL A  13;ILE A  67;VAL A  60;LEU A  95","None","1.40A","1z9hC-3piwA:undetectable","1z9hC-3piwA:20.22"],["3W1W_A_CHDA1503_0","FERROCHELATASE, MITOCHONDRIAL","3piw","TYPE I INTERFERON 2","Danio rerio",4,"ILE A  38;LEU A 128;VAL A 152;GLY A 151","None","0.85A","3w1wA-3piwA:undetectable","3w1wA-3piwA:16.98"],["3WZE_A_BAXA1201_2","VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2","3piw","TYPE I INTERFERON 2","Danio rerio",4,"VAL A 144;VAL A 145;LEU A 149;PHE A 125","None","0.60A","3wzeA-3piwA:undetectable","3wzeA-3piwA:19.61"],["4X1F_A_3WFA501_1","NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2","3piw","TYPE I INTERFERON 2","Danio rerio",5,"ASP A 155;LEU A  45;PHE A  71;LEU A 153;ILE A 156","None","1.06A","4x1fA-3piwA:undetectable","4x1fA-3piwA:20.25"],["4X1G_A_3WFA501_1","NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2","3piw","TYPE I INTERFERON 2","Danio rerio",5,"ASP A 155;LEU A  45;PHE A  71;LEU A 153;ILE A 156","None","1.05A","4x1gA-3piwA:undetectable","4x1gA-3piwA:20.25"],["5NKN_A_LOCA201_2","NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN","3piw","TYPE I INTERFERON 2","Danio rerio",3,"VAL A  92;LYS A 100;MET A 103","None","0.88A","5nknA-3piwA:undetectable","5nknA-3piwA:23.44"]]