SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pja'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 3pja TRANSLIN
(Homo
sapiens) 		4 / 7 VAL A 105
LEU A  42
LEU A 147
VAL A 119
 None
 0.85A 1jgsA-3pjaA:
1.8		 1jgsA-3pjaA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3pja TRANSLIN
(Homo
sapiens) 		4 / 6 LEU A 101
ARG A 116
THR A 120
LEU A 123
 None
 1.04A 1v54A-3pjaA:
2.7
1v54J-3pjaA:
undetectable		 1v54A-3pjaA:
16.09
1v54J-3pjaA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3pja TRANSLIN
(Homo
sapiens) 		4 / 6 LEU A 101
ARG A 116
THR A 120
LEU A 123
 None
 1.02A 2dyrA-3pjaA:
undetectable
2dyrJ-3pjaA:
undetectable		 2dyrA-3pjaA:
16.09
2dyrJ-3pjaA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3pja TRANSLIN
(Homo
sapiens) 		4 / 6 LEU A 101
ARG A 116
THR A 120
LEU A 123
 None
 0.97A 2dysA-3pjaA:
undetectable
2dysJ-3pjaA:
undetectable		 2dysA-3pjaA:
16.09
2dysJ-3pjaA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3pja TRANSLIN
(Homo
sapiens) 		4 / 6 LEU A 101
ARG A 116
THR A 120
LEU A 123
 None
 1.05A 2eijA-3pjaA:
undetectable
2eijJ-3pjaA:
undetectable		 2eijA-3pjaA:
16.09
2eijJ-3pjaA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 3pja TRANSLIN
(Homo
sapiens) 		4 / 8 THR A  34
VAL A  94
PHE A  65
ALA A 102
 None
 0.93A 2ij7C-3pjaA:
undetectable		 2ij7C-3pjaA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3pja TRANSLIN
(Homo
sapiens) 		4 / 6 LEU A 101
ARG A 116
THR A 120
LEU A 123
 None
 1.02A 2zxwA-3pjaA:
2.6
2zxwJ-3pjaA:
undetectable		 2zxwA-3pjaA:
16.09
2zxwJ-3pjaA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3pja TRANSLIN
(Homo
sapiens) 		4 / 6 ARG A 166
LEU A 154
PHE A 104
LEU A 108
 None
 0.96A 3abkP-3pjaA:
3.8
3abkW-3pjaA:
undetectable		 3abkP-3pjaA:
20.88
3abkW-3pjaA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3pja TRANSLIN
(Homo
sapiens) 		4 / 6 LEU A 101
ARG A 116
THR A 120
LEU A 123
 None
 0.99A 3abmA-3pjaA:
2.6
3abmJ-3pjaA:
undetectable		 3abmA-3pjaA:
16.09
3abmJ-3pjaA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3pja TRANSLIN
(Homo
sapiens) 		4 / 6 LEU A 101
ARG A 116
THR A 120
LEU A 123
 None
 1.00A 3asnA-3pjaA:
undetectable
3asnJ-3pjaA:
undetectable		 3asnA-3pjaA:
16.09
3asnJ-3pjaA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3pja TRANSLIN
(Homo
sapiens) 		4 / 6 LEU A 101
ARG A 116
THR A 120
LEU A 123
 None
 1.00A 3asoA-3pjaA:
undetectable
3asoJ-3pjaA:
undetectable		 3asoA-3pjaA:
16.09
3asoJ-3pjaA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 3pja TRANSLIN
(Homo
sapiens) 		3 / 3 HIS A  90
GLU A  89
HIS A  88
 None
 0.86A 3ba0A-3pjaA:
undetectable		 3ba0A-3pjaA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 3pja TRANSLIN
(Homo
sapiens) 		4 / 7 LEU A 191
GLU A 138
ASP A 136
SER A 190
 None
 1.42A 3dzgA-3pjaA:
undetectable		 3dzgA-3pjaA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 3pja TRANSLIN
(Homo
sapiens) 		4 / 6 LEU A  39
LEU A 101
LEU A 151
LEU A 147
 None
 1.03A 3q1eA-3pjaA:
undetectable
3q1eC-3pjaA:
undetectable		 3q1eA-3pjaA:
21.68
3q1eC-3pjaA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 3pja TRANSLIN
(Homo
sapiens) 		4 / 6 LEU A 151
LEU A 147
LEU A  39
LEU A 101
 None
 0.98A 3q1eA-3pjaA:
undetectable
3q1eC-3pjaA:
undetectable		 3q1eA-3pjaA:
21.68
3q1eC-3pjaA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 3pja TRANSLIN
(Homo
sapiens) 		4 / 5 LEU A 198
LEU A 177
LEU A 141
SER A 142
 None
 1.02A 3vhuA-3pjaA:
undetectable		 3vhuA-3pjaA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3pja TRANSLIN
(Homo
sapiens) 		4 / 6 ARG A 166
LEU A 154
PHE A 104
LEU A 108
 None
 0.97A 3wg7P-3pjaA:
4.0
3wg7W-3pjaA:
undetectable		 3wg7P-3pjaA:
20.88
3wg7W-3pjaA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 3pja TRANSLIN
(Homo
sapiens) 		5 / 12 VAL A 114
LEU A 151
LEU A  42
LEU A  41
PHE A  65
 None
 1.26A 4rtbA-3pjaA:
undetectable		 4rtbA-3pjaA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3pja TRANSLIN
(Homo
sapiens) 		4 / 5 GLU A 111
THR A 110
HIS A  64
LEU A  42
 None
 1.30A 5axaA-3pjaA:
undetectable		 5axaA-3pjaA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3pja TRANSLIN
(Homo
sapiens) 		4 / 5 GLU A 111
THR A 110
HIS A  64
LEU A  42
 None
 1.28A 5axaC-3pjaA:
undetectable		 5axaC-3pjaA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3pja TRANSLIN
(Homo
sapiens) 		4 / 7 ARG A 166
LEU A 154
PHE A 104
LEU A 108
 None
 0.96A 5b1aC-3pjaA:
3.8
5b1aJ-3pjaA:
undetectable		 5b1aC-3pjaA:
20.88
5b1aJ-3pjaA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3pja TRANSLIN
(Homo
sapiens) 		4 / 7 ARG A 166
LEU A 154
PHE A 104
LEU A 108
 None
 0.95A 5b1aP-3pjaA:
3.8
5b1aW-3pjaA:
undetectable		 5b1aP-3pjaA:
20.88
5b1aW-3pjaA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3pja TRANSLIN
(Homo
sapiens) 		4 / 7 ARG A 166
LEU A 154
PHE A 104
LEU A 108
 None
 0.96A 5b3sC-3pjaA:
3.8
5b3sJ-3pjaA:
undetectable		 5b3sC-3pjaA:
20.88
5b3sJ-3pjaA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3pja TRANSLIN
(Homo
sapiens) 		4 / 7 ARG A 166
LEU A 154
PHE A 104
LEU A 108
 None
 0.96A 5b3sP-3pjaA:
3.8		 5b3sP-3pjaA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3pja TRANSLIN
(Homo
sapiens) 		4 / 7 ARG A 166
LEU A 154
PHE A 104
LEU A 108
 None
 0.98A 5iy5C-3pjaA:
3.1
5iy5J-3pjaA:
undetectable		 5iy5C-3pjaA:
20.66
5iy5J-3pjaA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3pja TRANSLIN
(Homo
sapiens) 		4 / 5 ARG A 166
LEU A 154
PHE A 104
LEU A 108
 None
 0.96A 5x19C-3pjaA:
3.8
5x19J-3pjaA:
undetectable		 5x19C-3pjaA:
20.88
5x19J-3pjaA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3pja TRANSLIN
(Homo
sapiens) 		4 / 5 LEU A 198
PHE A 181
LEU A 177
PHE A 173
 None
 1.01A 5x19C-3pjaA:
3.8
5x19J-3pjaA:
undetectable		 5x19C-3pjaA:
20.88
5x19J-3pjaA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3pja TRANSLIN
(Homo
sapiens) 		4 / 5 ARG A 166
LEU A 154
PHE A 104
LEU A 108
 None
 0.94A 5x1bP-3pjaA:
3.8		 5x1bP-3pjaA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3pja TRANSLIN
(Homo
sapiens) 		4 / 6 ASP A 139
TYR A  84
ASP A 128
GLU A 117
 None
 1.46A 6mn5A-3pjaA:
undetectable		 6mn5A-3pjaA:
16.52