SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pjl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 3pjl 34 KDA MEMBRANE
ANTIGEN
(Treponema
pallidum) 		5 / 12 HIS A 124
ALA A 119
GLY A 120
GLU A  30
ASP A  74
 CO  A 186 (-3.3A)
None
None
EDO  A 189 (-4.4A)
None
 1.39A 1a4lD-3pjlA:
undetectable		 1a4lD-3pjlA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BMC_A_FOLA270_0
(PTERIDINE REDUCTASE)		 3pjl 34 KDA MEMBRANE
ANTIGEN
(Treponema
pallidum) 		5 / 11 PHE A 131
PHE A 178
TYR A 138
VAL A 112
GLU A  72
 None
None
None
None
CO  A 186 (-2.0A)
 1.33A 3bmcA-3pjlA:
undetectable		 3bmcA-3pjlA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BMC_D_FOLD270_0
(PTERIDINE REDUCTASE)		 3pjl 34 KDA MEMBRANE
ANTIGEN
(Treponema
pallidum) 		5 / 12 PHE A 131
PHE A 178
TYR A 138
VAL A 112
GLU A  72
 None
None
None
None
CO  A 186 (-2.0A)
 1.33A 3bmcD-3pjlA:
undetectable		 3bmcD-3pjlA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3pjl 34 KDA MEMBRANE
ANTIGEN
(Treponema
pallidum) 		3 / 3 PHE A 131
GLN A  61
PHE A 178
 None
 0.61A 3rv5A-3pjlA:
undetectable		 3rv5A-3pjlA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 3pjl 34 KDA MEMBRANE
ANTIGEN
(Treponema
pallidum) 		3 / 3 ASP A  68
LEU A 135
GLY A 134
 None
 0.47A 4xmfA-3pjlA:
undetectable		 4xmfA-3pjlA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEH_A_RPTA601_1
(SCAFFOLD PROTEIN D13)		 3pjl 34 KDA MEMBRANE
ANTIGEN
(Treponema
pallidum) 		5 / 10 GLN A  61
GLU A  30
PHE A  49
PHE A 114
PHE A 178
 None
EDO  A 189 (-4.4A)
EDO  A 189 ( 4.3A)
None
None
 1.34A 6behA-3pjlA:
1.8
6behB-3pjlA:
1.0
6behC-3pjlA:
2.1		 6behA-3pjlA:
14.29
6behB-3pjlA:
14.29
6behC-3pjlA:
14.29