SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pjp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 3pjp TRANSCRIPTION
ELONGATION FACTOR
SPT6
([Candida]
glabrata) 		5 / 12 PHE A1416
LEU A1418
LEU A1394
THR A1350
PHE A1392
 None
 1.20A 1og5A-3pjpA:
undetectable		 1og5A-3pjpA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 3pjp TRANSCRIPTION
ELONGATION FACTOR
SPT6
([Candida]
glabrata) 		3 / 3 ASP A1299
PHE A1301
ARG A1271
 None
 0.90A 2a3aA-3pjpA:
undetectable		 2a3aA-3pjpA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3pjp TRANSCRIPTION
ELONGATION FACTOR
SPT6
([Candida]
glabrata) 		3 / 3 THR A1359
ASP A1369
SER A1371
 None
 0.85A 2nxeA-3pjpA:
undetectable		 2nxeA-3pjpA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3pjp TRANSCRIPTION
ELONGATION FACTOR
SPT6
([Candida]
glabrata) 		3 / 3 THR A1359
ASP A1369
SER A1371
 None
 0.85A 2nxeB-3pjpA:
undetectable		 2nxeB-3pjpA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 3pjp TRANSCRIPTION
ELONGATION FACTOR
SPT6
([Candida]
glabrata) 		3 / 3 ARG A1285
HIS A1289
SER A1284
 ACT  A1445 (-4.7A)
None
ACT  A1445 (-3.1A)
 0.86A 4mjwA-3pjpA:
undetectable
4mjwB-3pjpA:
undetectable		 4mjwA-3pjpA:
16.55
4mjwB-3pjpA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 3pjp TRANSCRIPTION
ELONGATION FACTOR
SPT6
([Candida]
glabrata) 		3 / 3 SER A1284
ARG A1285
HIS A1289
 ACT  A1445 (-3.1A)
ACT  A1445 (-4.7A)
None
 0.91A 4mjwA-3pjpA:
undetectable
4mjwB-3pjpA:
undetectable		 4mjwA-3pjpA:
16.55
4mjwB-3pjpA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3pjp TRANSCRIPTION
ELONGATION FACTOR
SPT6
([Candida]
glabrata) 		4 / 5 VAL A1426
PRO A1424
GLY A1415
TYR A1423
 None
 1.34A 5x80A-3pjpA:
undetectable
5x80B-3pjpA:
undetectable		 5x80A-3pjpA:
20.60
5x80B-3pjpA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3pjp TRANSCRIPTION
ELONGATION FACTOR
SPT6
([Candida]
glabrata) 		4 / 5 PRO A1424
GLY A1415
TYR A1423
VAL A1426
 None
 1.34A 5x80C-3pjpA:
undetectable
5x80D-3pjpA:
undetectable		 5x80C-3pjpA:
20.60
5x80D-3pjpA:
20.60