SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pju'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 3pju CYCLIC DIMERIC GMP
BINDING PROTEIN
(Pseudomonas
fluorescens) 		5 / 12 LEU A 550
LEU A 553
GLY A 554
ALA A 578
LEU A 577
 None
 1.03A 1gs4A-3pjuA:
undetectable		 1gs4A-3pjuA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 3pju CYCLIC DIMERIC GMP
BINDING PROTEIN
(Pseudomonas
fluorescens) 		4 / 8 GLN A 536
ASN A 499
LEU A 500
LEU A 448
 None
C2E  A2256 (-3.2A)
None
C2E  A2256 (-3.8A)
 1.18A 1hk2A-3pjuA:
undetectable		 1hk2A-3pjuA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 3pju CYCLIC DIMERIC GMP
BINDING PROTEIN
(Pseudomonas
fluorescens) 		5 / 12 GLU A 630
ILE A 590
ILE A 587
ALA A 436
ARG A 597
 None
 1.46A 1ki7A-3pjuA:
undetectable		 1ki7A-3pjuA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 3pju CYCLIC DIMERIC GMP
BINDING PROTEIN
(Pseudomonas
fluorescens) 		5 / 12 GLU A 630
ILE A 590
ILE A 587
ALA A 436
ARG A 597
 None
 1.31A 1ki7B-3pjuA:
undetectable		 1ki7B-3pjuA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 3pju CYCLIC DIMERIC GMP
BINDING PROTEIN
(Pseudomonas
fluorescens) 		5 / 12 LEU A 550
LEU A 553
GLY A 554
ALA A 578
LEU A 577
 None
 0.96A 2oz7A-3pjuA:
undetectable		 2oz7A-3pjuA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3pju CYCLIC DIMERIC GMP
BINDING PROTEIN
(Pseudomonas
fluorescens) 		4 / 7 THR A 621
VAL A 619
ILE A 587
ILE A 590
 None
 0.87A 3deuA-3pjuA:
undetectable		 3deuA-3pjuA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3pju CYCLIC DIMERIC GMP
BINDING PROTEIN
(Pseudomonas
fluorescens) 		5 / 11 ASN A 512
LEU A 511
LEU A 546
GLU A 552
LEU A 550
 None
 1.10A 4wg0F-3pjuA:
undetectable
4wg0G-3pjuA:
undetectable
4wg0H-3pjuA:
undetectable		 4wg0F-3pjuA:
4.69
4wg0G-3pjuA:
4.69
4wg0H-3pjuA:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3pju CYCLIC DIMERIC GMP
BINDING PROTEIN
(Pseudomonas
fluorescens) 		4 / 4 ALA A 616
PRO A 432
LEU A 496
HIS A 444
 None
 1.30A 5eskA-3pjuA:
undetectable		 5eskA-3pjuA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3pju CYCLIC DIMERIC GMP
BINDING PROTEIN
(Pseudomonas
fluorescens) 		4 / 7 ILE A 569
LEU A 572
ARG A 605
LEU A 614
 None
 0.91A 5xdxA-3pjuA:
undetectable
5xdxJ-3pjuA:
undetectable		 5xdxA-3pjuA:
17.23
5xdxJ-3pjuA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3pju CYCLIC DIMERIC GMP
BINDING PROTEIN
(Pseudomonas
fluorescens) 		4 / 7 ILE A 569
LEU A 572
ARG A 605
LEU A 614
 None
 0.79A 6nmpA-3pjuA:
undetectable
6nmpJ-3pjuA:
undetectable		 6nmpA-3pjuA:
17.23
6nmpJ-3pjuA:
12.27