SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pkj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 7 HIS A 117
HIS A  93
LEU A 211
THR A  49
 None
 1.02A 1am6A-3pkjA:
undetectable		 1am6A-3pkjA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AZM_A_AZMA262_1
(CARBONIC ANHYDRASE I)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 8 HIS A 117
HIS A  93
LEU A 211
THR A  49
 None
 1.03A 1azmA-3pkjA:
undetectable		 1azmA-3pkjA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 LEU A  35
LEU A  38
VAL A  39
SER A  42
LEU A  96
 None
 1.25A 1db1A-3pkjA:
undetectable		 1db1A-3pkjA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 8 SER A  42
VAL A  39
LEU A  35
VAL A 259
 None
 1.03A 1fduB-3pkjA:
2.8		 1fduB-3pkjA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 11 ALA A  95
VAL A  32
LEU A  35
ALA A  36
LEU A  99
 None
 1.04A 1jinA-3pkjA:
undetectable		 1jinA-3pkjA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 6 ALA A  51
SER A  54
PHE A  62
ASN A 112
ASP A 114
 A2N  A1000 (-3.5A)
None
A2N  A1000 (-3.8A)
None
None
 0.71A 1yc2A-3pkjA:
22.7		 1yc2A-3pkjA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 5 ALA A  51
PHE A  62
ASN A 112
ASP A 114
 A2N  A1000 (-3.5A)
A2N  A1000 (-3.8A)
None
None
 0.67A 1yc2D-3pkjA:
22.7		 1yc2D-3pkjA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 7 ILE A  59
PHE A  62
ASN A 112
ASP A 114
 None
A2N  A1000 (-3.8A)
None
None
 0.38A 1yc2E-3pkjA:
24.2		 1yc2E-3pkjA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 7 ALA A  51
SER A  54
ILE A  59
ASN A 112
ASP A 114
 A2N  A1000 (-3.5A)
None
None
None
None
 0.43A 1yc5A-3pkjA:
24.7		 1yc5A-3pkjA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 7 SER A  54
ILE A  59
ASP A  61
ASP A 114
 None
None
A2N  A1000 (-4.0A)
None
 0.82A 1yc5A-3pkjA:
24.7		 1yc5A-3pkjA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 5 ALA A  51
ILE A  59
ASN A 112
ASP A 114
 A2N  A1000 (-3.5A)
None
None
None
 0.40A 2h4jA-3pkjA:
24.6		 2h4jA-3pkjA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 8 HIS A 117
HIS A  93
ALA A  95
LEU A 211
 None
 0.91A 2it4A-3pkjA:
undetectable		 2it4A-3pkjA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 LEU A 267
LEU A 263
LEU A 211
VAL A 237
VAL A  45
 None
 1.12A 2po5A-3pkjA:
undetectable		 2po5A-3pkjA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 11 MET A 260
LEU A  96
PHE A 122
LEU A  99
LEU A 207
 None
 1.39A 2po5B-3pkjA:
undetectable		 2po5B-3pkjA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 LEU A 267
LEU A 263
LEU A 211
VAL A 237
VAL A  45
 None
 1.09A 2qd4B-3pkjA:
undetectable		 2qd4B-3pkjA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 LEU A 108
THR A 213
GLY A 212
GLY A  52
LEU A  96
 None
A2N  A1000 (-3.8A)
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
 1.04A 2uvnA-3pkjA:
undetectable		 2uvnA-3pkjA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 7 THR A  82
ILE A  59
GLY A  58
HIS A  93
 None
 0.84A 2y7wC-3pkjA:
undetectable		 2y7wC-3pkjA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		3 / 3 THR A  49
SER A 110
PHE A  62
 None
None
A2N  A1000 (-3.8A)
 0.87A 3d4sA-3pkjA:
undetectable		 3d4sA-3pkjA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 SER A 202
ALA A 205
GLY A 232
HIS A  48
VAL A  46
 None
 1.18A 3f8wA-3pkjA:
undetectable		 3f8wA-3pkjA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 GLY A 268
LEU A  35
MET A 260
VAL A  39
ILE A 209
 None
 1.06A 3frqB-3pkjA:
0.1		 3frqB-3pkjA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 4 ARG A  88
ASP A  61
GLY A  50
THR A  92
 None
A2N  A1000 (-4.0A)
A2N  A1000 (-3.2A)
None
 1.30A 3k4vB-3pkjA:
undetectable		 3k4vB-3pkjA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 7 ASN A 112
ILE A  59
PHE A  80
PHE A  62
 None
None
None
A2N  A1000 (-3.8A)
 1.20A 3tvxB-3pkjA:
undetectable		 3tvxB-3pkjA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 8 PRO A 290
VAL A 102
LEU A 104
LEU A  99
 None
 0.88A 3u5kA-3pkjA:
undetectable		 3u5kA-3pkjA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 8 PRO A 290
VAL A 102
LEU A 104
LEU A  99
 None
 0.93A 3u5kD-3pkjA:
undetectable		 3u5kD-3pkjA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_1
(ADENOSINE KINASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.09A 3uboB-3pkjA:
4.9		 3uboB-3pkjA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		3 / 3 GLY A 132
THR A 182
ASN A 133
 None
 0.64A 3v4tD-3pkjA:
undetectable		 3v4tD-3pkjA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W6H_A_AZMA303_1
(CARBONIC ANHYDRASE 1)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 8 HIS A 117
HIS A  93
LEU A 211
THR A  49
 None
 1.02A 3w6hA-3pkjA:
undetectable		 3w6hA-3pkjA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 4 ASN A 112
ALA A  51
GLY A  50
THR A 213
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.2A)
A2N  A1000 (-3.8A)
 1.22A 4bboC-3pkjA:
undetectable		 4bboC-3pkjA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_1
(SUGAR KINASE PROTEIN)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.05A 4e3aA-3pkjA:
4.7		 4e3aA-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_B_ADNB500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.03A 4jkuB-3pkjA:
4.7		 4jkuB-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0S_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 11 HIS A 117
HIS A  93
LEU A 263
LEU A 211
THR A  49
 None
 1.21A 4k0sA-3pkjA:
undetectable		 4k0sA-3pkjA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_A_ADNA401_1
(SUGAR KINASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.05A 4k8pA-3pkjA:
4.6		 4k8pA-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_B_ADNB401_1
(SUGAR KINASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.05A 4k8pB-3pkjA:
4.7		 4k8pB-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_A_ADNA401_1
(SUGAR KINASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.04A 4k8tA-3pkjA:
4.8		 4k8tA-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_B_ADNB401_1
(SUGAR KINASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.04A 4k8tB-3pkjA:
4.6		 4k8tB-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_1
(SUGAR KINASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.04A 4k93A-3pkjA:
3.3		 4k93A-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_B_ADNB402_1
(SUGAR KINASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.05A 4k93B-3pkjA:
4.9		 4k93B-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_A_ADNA401_1
(SUGAR KINASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.04A 4k9cA-3pkjA:
undetectable		 4k9cA-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_B_ADNB401_1
(SUGAR KINASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.05A 4k9cB-3pkjA:
4.6		 4k9cB-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_A_ADNA401_1
(SUGAR KINASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.06A 4k9iA-3pkjA:
4.6		 4k9iA-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_B_ADNB401_1
(SUGAR KINASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.05A 4k9iB-3pkjA:
4.0		 4k9iB-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.03A 4kadA-3pkjA:
3.2		 4kadA-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.05A 4kadB-3pkjA:
3.2		 4kadB-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.04A 4lbxA-3pkjA:
4.7		 4lbxA-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.05A 4lbxB-3pkjA:
4.7		 4lbxB-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.03A 4lc4A-3pkjA:
4.9		 4lc4A-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.3A)
None
None
 1.04A 4lc4B-3pkjA:
4.7		 4lc4B-3pkjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 7 ILE A  59
PHE A  62
ASN A 112
ASP A 114
 None
A2N  A1000 (-3.8A)
None
None
 0.33A 4rmjA-3pkjA:
19.5		 4rmjA-3pkjA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 5 ASP A 185
GLU A 138
ARG A 180
THR A 182
 None
 1.15A 5uxcA-3pkjA:
undetectable		 5uxcA-3pkjA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 8 PRO A 290
VAL A 102
LEU A 104
LEU A  99
 None
 0.86A 5y1yA-3pkjA:
undetectable		 5y1yA-3pkjA:
18.42