SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pkm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 3pkm CAS6 PROTEIN
(Pyrococcus
furiosus) 		3 / 3 GLU A 232
LYS A 153
VAL A 144
 None
 0.85A 1l2iA-3pkmA:
undetectable		 1l2iA-3pkmA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3pkm CAS6 PROTEIN
(Pyrococcus
furiosus) 		4 / 7 LEU A 221
VAL A 224
GLY A 225
ASP A 172
 None
 0.74A 1t88A-3pkmA:
undetectable		 1t88A-3pkmA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3pkm CAS6 PROTEIN
(Pyrococcus
furiosus) 		4 / 7 LYS A 167
LEU A 170
GLN A 171
PHE A 136
 None
 0.96A 1v55P-3pkmA:
undetectable
1v55W-3pkmA:
undetectable		 1v55P-3pkmA:
19.59
1v55W-3pkmA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3pkm CAS6 PROTEIN
(Pyrococcus
furiosus) 		4 / 8 LEU A 221
VAL A 224
GLY A 225
ASP A 172
 None
 0.80A 2a1oA-3pkmA:
undetectable		 2a1oA-3pkmA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3pkm CAS6 PROTEIN
(Pyrococcus
furiosus) 		4 / 7 LYS A 167
LEU A 170
GLN A 171
PHE A 136
 None
 0.97A 2eijP-3pkmA:
undetectable
2eijW-3pkmA:
undetectable		 2eijP-3pkmA:
19.59
2eijW-3pkmA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 3pkm CAS6 PROTEIN
(Pyrococcus
furiosus) 		4 / 6 LEU A 119
LEU A  13
ILE A 122
ARG A  12
 None
None
None
U  G   2 ( 3.5A)
 0.96A 2rlfC-3pkmA:
undetectable
2rlfD-3pkmA:
undetectable		 2rlfC-3pkmA:
9.77
2rlfD-3pkmA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 3pkm CAS6 PROTEIN
(Pyrococcus
furiosus) 		5 / 12 GLY A 229
LEU A 139
SER A 140
SER A  90
LEU A 125
 None
 1.34A 3bxoA-3pkmA:
undetectable		 3bxoA-3pkmA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3pkm CAS6 PROTEIN
(Pyrococcus
furiosus) 		3 / 3 VAL A  24
LYS A  78
HIS A 210
 None
None
A  G   6 ( 3.6A)
 0.92A 3elzA-3pkmA:
undetectable		 3elzA-3pkmA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 3pkm CAS6 PROTEIN
(Pyrococcus
furiosus) 		4 / 8 PRO A 156
TYR A 153
GLN A 206
GLU A 232
 None
 1.07A 3oyaA-3pkmA:
undetectable		 3oyaA-3pkmA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 3pkm CAS6 PROTEIN
(Pyrococcus
furiosus) 		5 / 12 GLY A 239
GLY A 229
ALA A 143
ALA A 208
LEU A 139
 None
 1.02A 3p2kC-3pkmA:
undetectable		 3p2kC-3pkmA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 3pkm CAS6 PROTEIN
(Pyrococcus
furiosus) 		4 / 5 PHE A 198
PHE A 238
LEU A 211
PRO A 157
 A  G   7 ( 4.7A)
None
None
None
 1.40A 4o8zA-3pkmA:
undetectable		 4o8zA-3pkmA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 3pkm CAS6 PROTEIN
(Pyrococcus
furiosus) 		5 / 10 PRO A 128
PRO A  94
ALA A  97
PHE A   9
VAL A 124
 None
 1.41A 5m0oA-3pkmA:
undetectable		 5m0oA-3pkmA:
20.37