SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pko'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 11 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.97A 1rqjA-3pkoA:
26.8
1rqjA-3pkoA:
30.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 11 LEU A  84
ASP A  91
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.91A 1rqjA-3pkoA:
26.8
1rqjA-3pkoA:
30.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 11 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.95A 1rqjB-3pkoA:
26.9
1rqjB-3pkoA:
30.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 11 LEU A  84
ASP A  91
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.89A 1rqjB-3pkoA:
26.9
1rqjB-3pkoA:
30.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
3 / 3 ASP A 216
GLU A 150
ARG A  50
None
None
CIT  A 326 (-2.6A)
0.84A 1wopA-3pkoA:
undetectable
1wopA-3pkoA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 11 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.96A 1yhlA-3pkoA:
25.5
1yhlA-3pkoA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 11 LEU A  84
ASP A  91
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.97A 1yhlA-3pkoA:
25.5
1yhlA-3pkoA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 11 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.99A 1yq7A-3pkoA:
25.0
1yq7A-3pkoA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 11 LEU A  84
ASP A  91
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.94A 1yq7A-3pkoA:
25.0
1yq7A-3pkoA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 10 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.87A 1yv5A-3pkoA:
25.2
1yv5A-3pkoA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 10 LEU A  84
ASP A  91
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.88A 1yv5A-3pkoA:
25.2
1yv5A-3pkoA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 11 SER A 241
ILE A 162
LEU A 235
LEU A 259
TYR A 220
None
1.14A 2a15A-3pkoA:
undetectable
2a15A-3pkoA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
4 / 4 VAL A  89
LEU A  79
ILE A 146
LEU A 147
None
1.03A 2byoA-3pkoA:
undetectable
2byoA-3pkoA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 9 ASP A 234
GLN A 153
THR A 175
GLN A 212
ASP A 215
None
1.14A 2e91B-3pkoA:
20.5
2e91B-3pkoA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 11 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.94A 2f8cF-3pkoA:
25.5
2f8cF-3pkoA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 11 LEU A  84
ASP A  91
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.95A 2f8cF-3pkoA:
25.5
2f8cF-3pkoA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 10 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.91A 2f8zF-3pkoA:
25.5
2f8zF-3pkoA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 10 LEU A  84
ASP A  91
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.93A 2f8zF-3pkoA:
25.5
2f8zF-3pkoA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 12 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.86A 2f94F-3pkoA:
25.3
2f94F-3pkoA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 12 LEU A  84
ASP A  91
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.79A 2f94F-3pkoA:
25.3
2f94F-3pkoA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 10 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.96A 2f9kF-3pkoA:
25.7
2f9kF-3pkoA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 10 LEU A  84
ASP A  91
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.94A 2f9kF-3pkoA:
25.7
2f9kF-3pkoA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 9 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.91A 2o1oA-3pkoA:
24.9
2o1oA-3pkoA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 9 LEU A  84
ASP A  91
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.79A 2o1oA-3pkoA:
24.9
2o1oA-3pkoA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 10 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
1.10A 2o1oB-3pkoA:
25.2
2o1oB-3pkoA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_1
(PROTEASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 12 ALA A 114
ASP A 116
GLY A  82
VAL A  81
ILE A 102
None
1.22A 2o4lA-3pkoA:
undetectable
2o4lA-3pkoA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
4 / 7 GLY A  45
GLY A  46
VAL A  99
LEU A  41
None
0.82A 2oa1B-3pkoA:
undetectable
2oa1B-3pkoA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 10 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
1.18A 2q58A-3pkoA:
25.0
2q58A-3pkoA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
4 / 7 TYR A 167
ALA A 286
ALA A 290
THR A 294
None
0.92A 2wx2A-3pkoA:
undetectable
2wx2A-3pkoA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
4 / 6 ARG A 159
ILE A 162
ILE A 270
LEU A 276
None
0.97A 2xkwB-3pkoA:
2.2
2xkwB-3pkoA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
4 / 5 LEU A 321
GLN A 291
THR A 294
HIS A  -2
None
1.36A 2zj0C-3pkoA:
undetectable
2zj0C-3pkoA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
4 / 8 LEU A 189
PHE A  54
ALA A  75
ALA A  74
None
0.96A 3ax9B-3pkoA:
undetectable
3ax9B-3pkoA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
4 / 6 LEU A 147
ASP A  87
LEU A  84
HIS A  80
None
None
None
CIT  A 326 (-3.9A)
1.22A 3bj8C-3pkoA:
undetectable
3bj8D-3pkoA:
undetectable
3bj8C-3pkoA:
19.46
3bj8D-3pkoA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
4 / 5 LEU A 321
GLN A 291
THR A 294
HIS A  -2
None
1.36A 3ce6B-3pkoA:
undetectable
3ce6B-3pkoA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 12 GLY A 115
GLY A  82
VAL A 121
ALA A 111
LEU A  29
None
1.00A 3dh0B-3pkoA:
undetectable
3dh0B-3pkoA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 10 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.92A 3ez3D-3pkoA:
25.4
3ez3D-3pkoA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
4 / 8 TYR A 167
ALA A 286
ALA A 290
THR A 294
None
0.90A 3l4dA-3pkoA:
undetectable
3l4dA-3pkoA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 12 PRO A  51
ALA A  73
ALA A  74
LEU A  41
LEU A  23
None
1.00A 3mteB-3pkoA:
undetectable
3mteB-3pkoA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 11 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.94A 3n45F-3pkoA:
25.6
3n45F-3pkoA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 11 LEU A  84
ASP A  91
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.96A 3n45F-3pkoA:
25.6
3n45F-3pkoA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 10 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.93A 3n46F-3pkoA:
25.6
3n46F-3pkoA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 10 LEU A  84
ASP A  91
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.93A 3n46F-3pkoA:
25.6
3n46F-3pkoA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
4 / 5 LEU A 321
GLN A 291
THR A 294
HIS A  -2
None
1.44A 3n58C-3pkoA:
undetectable
3n58C-3pkoA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 12 PRO A  51
ALA A  73
ALA A  74
LEU A  41
LEU A  23
None
1.01A 3p2kA-3pkoA:
undetectable
3p2kA-3pkoA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 12 PRO A  51
ALA A  73
ALA A  74
LEU A  41
LEU A  23
None
1.01A 3p2kC-3pkoA:
undetectable
3p2kC-3pkoA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
6 / 12 GLY A  46
ALA A  73
ALA A  74
LEU A  41
LEU A  23
TYR A  22
None
1.43A 3p2kD-3pkoA:
undetectable
3p2kD-3pkoA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
6 / 12 PRO A  51
ALA A  73
ALA A  74
LEU A  41
LEU A  23
TYR A  22
None
1.41A 3p2kD-3pkoA:
undetectable
3p2kD-3pkoA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
4 / 8 VAL A  89
ARG A  96
ILE A 102
GLN A 103
None
CIT  A 326 ( 4.8A)
None
None
0.96A 3remA-3pkoA:
1.1
3remA-3pkoA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
4 / 8 VAL A  89
ARG A  96
ILE A 102
GLN A 103
None
CIT  A 326 ( 4.8A)
None
None
0.92A 3remB-3pkoA:
1.2
3remB-3pkoA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
3 / 3 GLN A  68
THR A 130
THR A 131
None
None
GOL  A 327 (-4.4A)
0.83A 4fu9A-3pkoA:
undetectable
4fu9A-3pkoA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
3 / 3 GLN A  68
THR A 130
THR A 131
None
None
GOL  A 327 (-4.4A)
0.83A 4fufA-3pkoA:
undetectable
4fufA-3pkoA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
3 / 3 TYR A 211
HIS A  80
ARG A  50
CIT  A 326 (-4.6A)
CIT  A 326 (-3.9A)
CIT  A 326 (-2.6A)
1.10A 4htfA-3pkoA:
undetectable
4htfA-3pkoA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 10 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.90A 4kpdA-3pkoA:
25.4
4kpdA-3pkoA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 10 LEU A  84
ASP A  91
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.90A 4kpdA-3pkoA:
25.4
4kpdA-3pkoA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 9 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.92A 4kpjA-3pkoA:
25.4
4kpjA-3pkoA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 9 LEU A  84
ASP A  91
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.91A 4kpjA-3pkoA:
25.4
4kpjA-3pkoA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 10 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.94A 4kq5A-3pkoA:
25.4
4kq5A-3pkoA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 10 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.92A 4kqsA-3pkoA:
25.5
4kqsA-3pkoA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 10 LEU A  84
ASP A  91
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.90A 4kqsA-3pkoA:
25.5
4kqsA-3pkoA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 12 TYR A 220
ASP A 216
ALA A 285
VAL A 277
GLY A 282
None
1.31A 4mm6A-3pkoA:
undetectable
4mm6A-3pkoA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 10 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.87A 4nkeA-3pkoA:
25.3
4nkeA-3pkoA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 10 LEU A  84
ASP A  91
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.88A 4nkeA-3pkoA:
25.3
4nkeA-3pkoA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 9 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.97A 4nkfA-3pkoA:
25.6
4nkfA-3pkoA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 10 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.89A 4nuaA-3pkoA:
25.4
4nuaA-3pkoA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 10 LEU A  84
ASP A  91
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.90A 4nuaA-3pkoA:
25.4
4nuaA-3pkoA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 9 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.94A 4oguA-3pkoA:
25.4
4oguA-3pkoA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 9 LEU A  84
ASP A  91
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.96A 4oguA-3pkoA:
25.4
4oguA-3pkoA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 11 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.97A 4p0wA-3pkoA:
25.4
4p0wA-3pkoA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 11 LEU A  84
ASP A  91
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
1.00A 4p0wA-3pkoA:
25.4
4p0wA-3pkoA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
3 / 3 LEU A 289
ASP A 292
TYR A 293
None
0.53A 4qc6B-3pkoA:
undetectable
4qc6B-3pkoA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
4 / 7 LEU A 259
LEU A 248
ILE A 162
ASP A 161
None
0.74A 4rmjA-3pkoA:
undetectable
4rmjA-3pkoA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 10 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.88A 4rxdA-3pkoA:
24.7
4rxdA-3pkoA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 10 LEU A  84
ASP A  91
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.89A 4rxdA-3pkoA:
24.7
4rxdA-3pkoA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 10 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.87A 4rxdB-3pkoA:
25.0
4rxdB-3pkoA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 10 LEU A  84
ASP A  91
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.89A 4rxdB-3pkoA:
25.0
4rxdB-3pkoA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 10 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.87A 4rxdC-3pkoA:
25.0
4rxdC-3pkoA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 10 LEU A  84
ASP A  91
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.87A 4rxdC-3pkoA:
25.0
4rxdC-3pkoA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
4 / 8 LEU A  84
ASP A  87
ARG A  96
LYS A 174
None
None
CIT  A 326 ( 4.8A)
None
0.99A 4umjA-3pkoA:
26.6
4umjA-3pkoA:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
4 / 8 LEU A  84
ASP A  91
ARG A  96
LYS A 174
None
None
CIT  A 326 ( 4.8A)
None
0.70A 4umjA-3pkoA:
26.6
4umjA-3pkoA:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 9 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.89A 4umjB-3pkoA:
26.7
4umjB-3pkoA:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 9 LEU A  84
ASP A  91
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.65A 4umjB-3pkoA:
26.7
4umjB-3pkoA:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 11 LEU A 245
LEU A 246
LEU A 164
ALA A 290
LEU A 289
None
0.98A 4wg0B-3pkoA:
undetectable
4wg0C-3pkoA:
undetectable
4wg0D-3pkoA:
undetectable
4wg0B-3pkoA:
2.99
4wg0C-3pkoA:
2.99
4wg0D-3pkoA:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 11 LEU A 245
LEU A 246
LEU A 164
ALA A 290
LEU A 289
None
1.01A 4wg0D-3pkoA:
undetectable
4wg0E-3pkoA:
undetectable
4wg0F-3pkoA:
undetectable
4wg0D-3pkoA:
2.99
4wg0E-3pkoA:
2.99
4wg0F-3pkoA:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 11 ALA A 290
LEU A 289
LEU A 164
LEU A 245
LEU A 246
None
1.00A 4wg0C-3pkoA:
undetectable
4wg0D-3pkoA:
undetectable
4wg0E-3pkoA:
undetectable
4wg0C-3pkoA:
2.99
4wg0D-3pkoA:
2.99
4wg0E-3pkoA:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 11 LEU A 245
LEU A 246
LEU A 164
ALA A 290
LEU A 289
None
1.01A 4wg0F-3pkoA:
undetectable
4wg0G-3pkoA:
undetectable
4wg0H-3pkoA:
undetectable
4wg0F-3pkoA:
2.99
4wg0G-3pkoA:
2.99
4wg0H-3pkoA:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 11 ALA A 290
LEU A 289
LEU A 164
LEU A 245
LEU A 246
None
1.00A 4wg0E-3pkoA:
undetectable
4wg0F-3pkoA:
undetectable
4wg0G-3pkoA:
undetectable
4wg0E-3pkoA:
2.99
4wg0F-3pkoA:
2.99
4wg0G-3pkoA:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 11 LEU A 245
LEU A 246
LEU A 164
ALA A 290
LEU A 289
None
1.03A 4wg0H-3pkoA:
undetectable
4wg0I-3pkoA:
undetectable
4wg0J-3pkoA:
undetectable
4wg0H-3pkoA:
2.99
4wg0I-3pkoA:
2.99
4wg0J-3pkoA:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 11 ALA A 290
LEU A 289
LEU A 164
LEU A 245
LEU A 246
None
1.03A 4wg0G-3pkoA:
undetectable
4wg0H-3pkoA:
undetectable
4wg0I-3pkoA:
undetectable
4wg0G-3pkoA:
2.99
4wg0H-3pkoA:
2.99
4wg0I-3pkoA:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 11 ALA A 290
LEU A 289
LEU A 164
LEU A 245
LEU A 246
None
1.04A 4wg0K-3pkoA:
undetectable
4wg0L-3pkoA:
undetectable
4wg0M-3pkoA:
undetectable
4wg0K-3pkoA:
2.99
4wg0L-3pkoA:
2.99
4wg0M-3pkoA:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
3 / 3 ASP A  88
GLU A 150
SER A  44
None
0.77A 5bw4B-3pkoA:
undetectable
5bw4B-3pkoA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 12 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.90A 5cg5A-3pkoA:
25.2
5cg5A-3pkoA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 12 LEU A  84
ASP A  91
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.90A 5cg5A-3pkoA:
25.2
5cg5A-3pkoA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 12 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.88A 5cg6A-3pkoA:
25.6
5cg6A-3pkoA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 12 LEU A  84
ASP A  91
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.87A 5cg6A-3pkoA:
25.6
5cg6A-3pkoA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 12 THR A 200
ARG A 201
ILE A 203
GLY A 204
ILE A 207
None
0.86A 5ifuA-3pkoA:
undetectable
5ifuA-3pkoA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA407_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
4 / 5 ASP A  21
THR A  17
GLN A  20
ARG A   3
None
1.27A 5k9dA-3pkoA:
undetectable
5k9dA-3pkoA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
4 / 7 GLY A  82
ALA A 111
ASP A 116
PHE A 119
None
0.99A 5mvsA-3pkoA:
undetectable
5mvsA-3pkoA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
4 / 8 GLY A  82
ALA A 111
ASP A 116
PHE A 119
None
0.94A 5mvsB-3pkoA:
undetectable
5mvsB-3pkoA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 12 HIS A  -3
SER A 237
VAL A 239
ASP A 215
ASP A 216
None
1.43A 6bxnA-3pkoA:
undetectable
6bxnA-3pkoA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
4 / 5 ILE A 270
GLN A 228
THR A 227
LEU A 244
None
1.09A 6f3mD-3pkoA:
undetectable
6f3mD-3pkoA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
5 / 9 LEU A 259
MET A 265
VAL A 273
LEU A 232
ILE A 270
None
1.17A 6fdyU-3pkoA:
undetectable
6fdyU-3pkoA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA806_0
(GEPHYRIN)
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis)
4 / 4 MET A 118
GLY A 115
HIS A  86
GLY A  82
None
1.25A 6fgdA-3pkoA:
undetectable
6fgdA-3pkoA:
23.73