SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pl1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		5 / 12 HIS A  71
HIS A  57
HIS A  51
ASP A  49
ASP A   8
 FE2  A 188 (-3.4A)
FE2  A 188 (-3.5A)
FE2  A 188 (-3.5A)
FE2  A 188 (-2.6A)
None
 1.22A 1a4lA-3pl1A:
undetectable		 1a4lA-3pl1A:
19.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WT9_A_NIOA1216_1
(NICOTINAMIDASE)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		7 / 10 ASP A   8
PHE A  13
LEU A  19
ASP A  49
TRP A  68
HIS A  71
ALA A 134
 None
None
None
FE2  A 188 (-2.6A)
None
FE2  A 188 (-3.4A)
None
 0.63A 2wt9A-3pl1A:
25.3		 2wt9A-3pl1A:
33.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WT9_B_NIOB1216_1
(NICOTINAMIDASE)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		7 / 9 ASP A   8
PHE A  13
LEU A  19
ASP A  49
TRP A  68
HIS A  71
ALA A 134
 None
None
None
FE2  A 188 (-2.6A)
None
FE2  A 188 (-3.4A)
None
 0.61A 2wt9B-3pl1A:
25.3		 2wt9B-3pl1A:
33.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		4 / 7 TYR A  41
VAL A 130
TYR A  34
ILE A   6
 None
 0.80A 2xz5B-3pl1A:
undetectable
2xz5E-3pl1A:
undetectable		 2xz5B-3pl1A:
21.37
2xz5E-3pl1A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		4 / 8 ILE A   6
TYR A  41
VAL A 130
TYR A  34
 None
 0.79A 2xz5A-3pl1A:
undetectable
2xz5C-3pl1A:
undetectable		 2xz5A-3pl1A:
21.37
2xz5C-3pl1A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		4 / 8 ILE A   6
TYR A  41
VAL A 130
TYR A  34
 None
 0.78A 2xz5C-3pl1A:
undetectable
2xz5D-3pl1A:
undetectable		 2xz5C-3pl1A:
21.37
2xz5D-3pl1A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		4 / 7 ILE A   6
TYR A  41
VAL A 130
TYR A  34
 None
 0.78A 2xz5D-3pl1A:
undetectable
2xz5E-3pl1A:
undetectable		 2xz5D-3pl1A:
21.37
2xz5E-3pl1A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		4 / 8 TYR A  34
VAL A  44
TYR A  41
VAL A 131
 None
 1.20A 2y05A-3pl1A:
3.9
2y05B-3pl1A:
4.0		 2y05A-3pl1A:
20.92
2y05B-3pl1A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		4 / 5 GLN A 141
THR A 142
THR A 160
LEU A 182
 None
 1.38A 2zj0A-3pl1A:
2.8		 2zj0A-3pl1A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		4 / 5 GLN A 141
THR A 142
THR A 160
LEU A 182
 None
 1.34A 3ce6C-3pl1A:
2.6		 3ce6C-3pl1A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NJZ_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		5 / 12 GLN A  10
HIS A  51
HIS A  57
HIS A  71
ASP A   8
 None
FE2  A 188 (-3.5A)
FE2  A 188 (-3.5A)
FE2  A 188 (-3.4A)
None
 1.41A 3njzA-3pl1A:
undetectable		 3njzA-3pl1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		5 / 6 GLN A  10
HIS A  51
HIS A  57
HIS A  71
ASP A   8
 None
FE2  A 188 (-3.5A)
FE2  A 188 (-3.5A)
FE2  A 188 (-3.4A)
None
 1.18A 3nvcA-3pl1A:
undetectable		 3nvcA-3pl1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		5 / 11 ASP A   8
PHE A  13
LEU A  19
ASP A  49
HIS A  71
 None
None
None
FE2  A 188 (-2.6A)
FE2  A 188 (-3.4A)
 0.67A 3o94A-3pl1A:
21.9		 3o94A-3pl1A:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		5 / 11 ASP A   8
PHE A  13
LEU A  19
ASP A  49
HIS A  71
 None
None
None
FE2  A 188 (-2.6A)
FE2  A 188 (-3.4A)
 0.59A 3o94B-3pl1A:
21.8		 3o94B-3pl1A:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		5 / 11 ASP A   8
PHE A  13
LEU A  19
ASP A  49
HIS A  71
 None
None
None
FE2  A 188 (-2.6A)
FE2  A 188 (-3.4A)
 0.62A 3o94C-3pl1A:
21.7		 3o94C-3pl1A:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		5 / 11 ASP A   8
PHE A  13
LEU A  19
ASP A  49
HIS A  71
 None
None
None
FE2  A 188 (-2.6A)
FE2  A 188 (-3.4A)
 0.64A 3o94D-3pl1A:
21.8		 3o94D-3pl1A:
29.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R2J_A_NIOA311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		8 / 9 ASP A   8
LEU A  19
ASP A  49
TRP A  68
HIS A  71
LYS A  96
ALA A 134
CYH A 138
 None
None
FE2  A 188 (-2.6A)
None
FE2  A 188 (-3.4A)
None
None
None
 0.82A 3r2jA-3pl1A:
25.5		 3r2jA-3pl1A:
36.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R2J_B_NIOB311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		7 / 11 ASP A   8
PHE A  13
ASP A  49
TRP A  68
HIS A  71
ALA A 134
CYH A 138
 None
None
FE2  A 188 (-2.6A)
None
FE2  A 188 (-3.4A)
None
None
 0.74A 3r2jB-3pl1A:
25.6		 3r2jB-3pl1A:
36.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R2J_B_NIOB311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		8 / 11 ASP A   8
PHE A  13
LEU A  19
ASP A  49
TRP A  68
HIS A  71
LYS A  96
CYH A 138
 None
None
None
FE2  A 188 (-2.6A)
None
FE2  A 188 (-3.4A)
None
None
 0.64A 3r2jB-3pl1A:
25.6		 3r2jB-3pl1A:
36.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		5 / 12 ASP A   8
ASP A  49
HIS A  71
ALA A 134
CYH A 138
 None
FE2  A 188 (-2.6A)
FE2  A 188 (-3.4A)
None
None
 1.30A 3r2jC-3pl1A:
25.8		 3r2jC-3pl1A:
36.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		9 / 12 ASP A   8
PHE A  13
LEU A  19
ASP A  49
HIS A  51
TRP A  68
HIS A  71
LYS A  96
CYH A 138
 None
None
None
FE2  A 188 (-2.6A)
FE2  A 188 (-3.5A)
None
FE2  A 188 (-3.4A)
None
None
 0.63A 3r2jC-3pl1A:
25.8		 3r2jC-3pl1A:
36.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		9 / 12 ASP A   8
PHE A  13
LEU A  19
ASP A  49
TRP A  68
HIS A  71
LYS A  96
ALA A 134
CYH A 138
 None
None
None
FE2  A 188 (-2.6A)
None
FE2  A 188 (-3.4A)
None
None
None
 0.77A 3r2jC-3pl1A:
25.8		 3r2jC-3pl1A:
36.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  19
HIS A  57
HIS A  71
ALA A 134
CYH A 138
 None
FE2  A 188 (-3.5A)
FE2  A 188 (-3.4A)
None
None
 1.15A 3r2jC-3pl1A:
25.8		 3r2jC-3pl1A:
36.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R2J_D_NIOD311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		9 / 11 ASP A   8
PHE A  13
LEU A  19
ASP A  49
TRP A  68
HIS A  71
LYS A  96
ALA A 134
CYH A 138
 None
None
None
FE2  A 188 (-2.6A)
None
FE2  A 188 (-3.4A)
None
None
None
 0.74A 3r2jD-3pl1A:
25.6		 3r2jD-3pl1A:
36.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 182
ALA A 143
VAL A   7
VAL A 157
VAL A 155
 None
 0.99A 3ucbB-3pl1A:
undetectable		 3ucbB-3pl1A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_B_QMRB301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		5 / 9 TYR A  41
VAL A 130
TYR A  34
VAL A 139
ILE A   6
 None
 0.94A 4aftB-3pl1A:
0.0
4aftC-3pl1A:
0.0		 4aftB-3pl1A:
21.37
4aftC-3pl1A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_C_QMRC301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		5 / 9 TYR A  41
VAL A 130
TYR A  34
VAL A 139
ILE A   6
 None
 0.90A 4aftC-3pl1A:
0.0
4aftD-3pl1A:
0.0		 4aftC-3pl1A:
21.37
4aftD-3pl1A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		5 / 8 TYR A  41
VAL A 130
TYR A  34
VAL A 139
ILE A   6
 None
 0.88A 4aftD-3pl1A:
undetectable
4aftE-3pl1A:
undetectable		 4aftD-3pl1A:
21.37
4aftE-3pl1A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		4 / 8 TYR A  41
VAL A 130
TYR A  34
ILE A   6
 None
 0.82A 4bqtC-3pl1A:
undetectable
4bqtD-3pl1A:
undetectable		 4bqtC-3pl1A:
21.37
4bqtD-3pl1A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  90
LEU A 116
GLY A 105
THR A 142
VAL A 130
 None
 1.06A 4c9oA-3pl1A:
undetectable		 4c9oA-3pl1A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		3 / 3 TYR A 103
ARG A 140
HIS A 137
 None
 0.94A 4fubA-3pl1A:
undetectable		 4fubA-3pl1A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		4 / 5 GLN A 141
THR A 142
THR A 160
LEU A 172
 None
 1.35A 4lvcA-3pl1A:
3.0		 4lvcA-3pl1A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		4 / 5 GLN A 141
THR A 142
THR A 160
LEU A 172
 None
 1.35A 4lvcC-3pl1A:
3.2		 4lvcC-3pl1A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_A_AZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		5 / 11 VAL A 155
VAL A 157
LEU A 172
THR A 168
ALA A 171
 None
 1.50A 4ygfA-3pl1A:
undetectable		 4ygfA-3pl1A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_G_MZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 155
VAL A 157
LEU A 172
THR A 168
ALA A 171
 None
 1.42A 4yhaG-3pl1A:
undetectable		 4yhaG-3pl1A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AIN_A_QMRA1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		5 / 10 TYR A  41
VAL A 130
TYR A  34
VAL A 139
ILE A   6
 None
 0.94A 5ainA-3pl1A:
0.0
5ainB-3pl1A:
0.0		 5ainA-3pl1A:
21.30
5ainB-3pl1A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AIN_B_QMRB1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		5 / 10 TYR A  41
VAL A 130
TYR A  34
VAL A 139
ILE A   6
 None
 0.99A 5ainB-3pl1A:
0.0
5ainC-3pl1A:
0.0		 5ainB-3pl1A:
21.30
5ainC-3pl1A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AIN_C_QMRC1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		5 / 10 TYR A  41
VAL A 130
TYR A  34
VAL A 139
ILE A   6
 None
 0.83A 5ainC-3pl1A:
0.0
5ainD-3pl1A:
0.0		 5ainC-3pl1A:
21.30
5ainD-3pl1A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AIN_D_QMRD1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		5 / 10 TYR A  41
VAL A 130
TYR A  34
VAL A 139
ILE A   6
 None
 0.86A 5ainD-3pl1A:
0.0
5ainE-3pl1A:
0.0		 5ainD-3pl1A:
21.30
5ainE-3pl1A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AIN_E_QMRE1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		5 / 10 VAL A 139
ILE A   6
TYR A  41
VAL A 130
TYR A  34
 None
 0.92A 5ainA-3pl1A:
0.0
5ainE-3pl1A:
0.0		 5ainA-3pl1A:
21.30
5ainE-3pl1A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		4 / 4 GLN A 141
THR A 142
THR A 160
LEU A 172
 None
 1.40A 5m5kA-3pl1A:
3.3		 5m5kA-3pl1A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		4 / 4 GLN A 141
THR A 142
THR A 160
LEU A 172
 None
 1.36A 5m66B-3pl1A:
3.3		 5m66B-3pl1A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O87_A_NCTA601_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		5 / 10 TYR A  41
VAL A 130
TYR A  34
VAL A 139
ILE A   6
 None
 0.93A 5o87A-3pl1A:
0.0
5o87B-3pl1A:
0.0		 5o87A-3pl1A:
19.13
5o87B-3pl1A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		5 / 9 VAL A  44
LEU A  35
ALA A  39
VAL A 131
ILE A   6
 None
 1.21A 5om2A-3pl1A:
undetectable
5om2B-3pl1A:
undetectable		 5om2A-3pl1A:
17.44
5om2B-3pl1A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 131
ARG A   2
TYR A  41
LEU A 120
 None
 0.96A 5umwB-3pl1A:
undetectable
5umwE-3pl1A:
undetectable		 5umwB-3pl1A:
19.43
5umwE-3pl1A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		5 / 12 TRP A  68
ARG A 140
ALA A 171
PHE A  13
VAL A 139
 None
 1.23A 6clxA-3pl1A:
undetectable		 6clxA-3pl1A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_B_ADNB502_2
(-)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		4 / 4 GLN A 141
THR A 142
THR A 160
LEU A 172
 None
 1.38A 6f3mB-3pl1A:
3.2		 6f3mB-3pl1A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		4 / 5 GLN A 141
THR A 142
THR A 160
LEU A 172
 None
 1.36A 6gbnD-3pl1A:
undetectable		 6gbnD-3pl1A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  57
HIS A  71
HIS A  51
 FE2  A 188 (-3.5A)
FE2  A 188 (-3.4A)
FE2  A 188 (-3.5A)
 0.74A 6giqa-3pl1A:
undetectable		 6giqa-3pl1A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		4 / 8 ASP A  40
ARG A   2
GLU A 127
GLU A 181
 None
 1.14A 6mn4D-3pl1A:
undetectable		 6mn4D-3pl1A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)
(Mycobacterium
tuberculosis) 		4 / 7 ARG A   2
HIS A  42
ASP A 129
GLU A 181
 None
 1.41A 6mn4F-3pl1A:
undetectable		 6mn4F-3pl1A:
23.19