SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pl5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		5 / 11 THR A  62
PHE A  89
LEU A 171
PHE A 163
VAL A 271
 PLM  A 702 (-3.7A)
PLM  A 702 ( 4.9A)
None
PLM  A 702 (-3.9A)
None
 1.42A 1q23I-3pl5A:
undetectable		 1q23I-3pl5A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		5 / 11 THR A  62
PHE A  89
LEU A 171
PHE A 163
VAL A 271
 PLM  A 702 (-3.7A)
PLM  A 702 ( 4.9A)
None
PLM  A 702 (-3.9A)
None
 1.44A 1q23J-3pl5A:
undetectable		 1q23J-3pl5A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		5 / 11 THR A  62
PHE A  89
LEU A 171
PHE A 163
VAL A 271
 PLM  A 702 (-3.7A)
PLM  A 702 ( 4.9A)
None
PLM  A 702 (-3.9A)
None
 1.41A 1q23L-3pl5A:
undetectable		 1q23L-3pl5A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		5 / 12 ILE A  87
THR A  10
THR A 121
VAL A 119
ILE A 118
 None
 1.30A 2yzqA-3pl5A:
undetectable		 2yzqA-3pl5A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8F_A_DM1A127_1
(TRANSCRIPTIONAL
REGULATOR, PADR-LIKE
FAMILY)		 3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		5 / 10 ALA A 136
VAL A  23
ALA A  11
VAL A 259
TRP A  17
 None
 1.35A 3f8fA-3pl5A:
undetectable
3f8fB-3pl5A:
undetectable		 3f8fA-3pl5A:
18.44
3f8fB-3pl5A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		5 / 12 LEU A 131
GLY A 129
ILE A 152
ALA A 136
LEU A  85
 None
 1.02A 3gwvA-3pl5A:
undetectable		 3gwvA-3pl5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		3 / 3 GLU A 150
LEU A 153
ASP A 154
 None
 0.34A 3ko0A-3pl5A:
undetectable		 3ko0A-3pl5A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		3 / 3 GLU A 150
LEU A 153
ASP A 154
 None
 0.22A 3ko0T-3pl5A:
undetectable		 3ko0T-3pl5A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		5 / 10 THR A  62
PHE A  89
LEU A 171
PHE A 163
VAL A 271
 PLM  A 702 (-3.7A)
PLM  A 702 ( 4.9A)
None
PLM  A 702 (-3.9A)
None
 1.43A 3u9fE-3pl5A:
undetectable		 3u9fE-3pl5A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		5 / 12 THR A  62
PHE A  89
LEU A 171
PHE A 163
VAL A 271
 PLM  A 702 (-3.7A)
PLM  A 702 ( 4.9A)
None
PLM  A 702 (-3.9A)
None
 1.42A 3u9fH-3pl5A:
undetectable
3u9fI-3pl5A:
undetectable		 3u9fH-3pl5A:
18.95
3u9fI-3pl5A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		4 / 5 LEU A 108
ILE A 118
ALA A 103
PHE A  74
 None
 0.96A 4dc3B-3pl5A:
undetectable		 4dc3B-3pl5A:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		5 / 12 ASN A 237
ASP A 238
ALA A 234
PHE A 279
ARG A 211
 None
None
PLM  A 702 ( 4.9A)
None
None
 1.08A 4u8yB-3pl5A:
undetectable		 4u8yB-3pl5A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		4 / 4 LEU A 171
ILE A 267
HIS A 270
VAL A 271
 None
PLM  A 702 ( 4.7A)
PLM  A 702 (-3.6A)
None
 1.07A 4xyzA-3pl5A:
0.2		 4xyzA-3pl5A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		5 / 12 SER A  91
LEU A  28
THR A  10
ALA A 124
TYR A  86
 None
PLM  A 702 (-4.9A)
None
PLM  A 702 (-3.6A)
None
 1.48A 5dsgB-3pl5A:
undetectable		 5dsgB-3pl5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		3 / 3 ALA A 241
ASN A 244
LEU A 245
 None
 0.50A 5i1nC-3pl5A:
undetectable		 5i1nC-3pl5A:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		3 / 3 ALA A 241
ASN A 244
LEU A 245
 None
 0.32A 5i1nB-3pl5A:
undetectable		 5i1nB-3pl5A:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		3 / 3 ALA A 241
ASN A 244
LEU A 245
 None
 0.40A 5i1oC-3pl5A:
undetectable		 5i1oC-3pl5A:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		3 / 3 ALA A 241
ASN A 244
LEU A 245
 None
 0.37A 5i1oA-3pl5A:
undetectable		 5i1oA-3pl5A:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		3 / 3 ALA A 241
ASN A 244
LEU A 245
 None
 0.37A 5i1pA-3pl5A:
undetectable		 5i1pA-3pl5A:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		3 / 3 ALA A 241
ASN A 244
LEU A 245
 None
 0.42A 5i1pD-3pl5A:
undetectable		 5i1pD-3pl5A:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		4 / 8 VAL A 259
LEU A 261
ASN A  21
MET A 133
 None
 0.84A 5nujA-3pl5A:
undetectable		 5nujA-3pl5A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		4 / 7 ARG A 176
LEU A 263
THR A 161
THR A  39
 PLM  A 702 (-3.9A)
PLM  A 702 ( 4.8A)
PLM  A 702 ( 4.8A)
None
 1.03A 5vc0A-3pl5A:
undetectable		 5vc0A-3pl5A:
21.65