SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pls'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_A_DXCA801_0
(STEROID
DELTA-ISOMERASE)		 3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 12 ASP A1226
GLY A1094
VAL A1159
MET A1215
ALA A1225
 MG  A   1 ( 3.2A)
None
None
ANP  A1358 (-3.9A)
None
 1.34A 1e3vA-3plsA:
undetectable		 1e3vA-3plsA:
16.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 12 VAL A1096
ALA A1112
LEU A1144
LEU A1199
HIS A1206
 ANP  A1358 (-4.4A)
ANP  A1358 ( 3.8A)
None
None
None
 0.54A 1uwjA-3plsA:
7.2		 1uwjA-3plsA:
30.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		4 / 7 PHE A1273
LEU A1190
ALA A1193
PHE A1334
 None
 0.81A 2vcvL-3plsA:
undetectable		 2vcvL-3plsA:
20.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		10 / 12 GLY A1089
VAL A1096
ALA A1112
LEU A1144
LEU A1161
TYR A1163
MET A1164
GLY A1167
MET A1215
ALA A1225
 ANP  A1358 ( 3.7A)
ANP  A1358 (-4.4A)
ANP  A1358 ( 3.8A)
None
ANP  A1358 ( 4.1A)
ANP  A1358 (-4.3A)
None
None
ANP  A1358 (-3.9A)
None
 0.55A 2wgjA-3plsA:
34.6		 2wgjA-3plsA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		8 / 12 VAL A1096
ALA A1112
MET A1135
LEU A1146
GLY A1167
ASP A1226
PHE A1227
LEU A1229
 ANP  A1358 (-4.4A)
ANP  A1358 ( 3.8A)
None
None
None
MG  A   1 ( 3.2A)
None
None
 0.71A 3bbtB-3plsA:
31.2		 3bbtB-3plsA:
35.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		8 / 12 VAL A1096
ALA A1112
LYS A1114
MET A1135
GLY A1167
ASP A1226
PHE A1227
LEU A1229
 ANP  A1358 (-4.4A)
ANP  A1358 ( 3.8A)
ANP  A1358 (-3.2A)
None
None
MG  A   1 ( 3.2A)
None
None
 0.80A 3bbtD-3plsA:
15.6		 3bbtD-3plsA:
35.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		3 / 3 SER A1117
ASP A1226
ASP A1168
 None
MG  A   1 ( 3.2A)
ANP  A1358 (-4.1A)
 0.80A 3uj7A-3plsA:
undetectable		 3uj7A-3plsA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		4 / 8 ARG A1086
HIS A1083
VAL A1081
VAL A1080
 None
 1.09A 3uy4A-3plsA:
undetectable		 3uy4A-3plsA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		6 / 12 ILE A1088
GLY A1091
GLY A1094
VAL A1096
ALA A1112
ASP A1226
 ANP  A1358 (-4.3A)
ANP  A1358 (-3.4A)
None
ANP  A1358 (-4.4A)
ANP  A1358 ( 3.8A)
MG  A   1 ( 3.2A)
 0.79A 3v5wA-3plsA:
7.2		 3v5wA-3plsA:
17.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		6 / 12 ALA A1112
LEU A1144
LEU A1161
MET A1164
GLY A1167
ASP A1168
 ANP  A1358 ( 3.8A)
None
ANP  A1358 ( 4.1A)
None
None
ANP  A1358 (-4.1A)
 0.51A 3zbfA-3plsA:
29.2		 3zbfA-3plsA:
35.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		6 / 9 VAL A1096
ALA A1112
LEU A1161
MET A1164
GLY A1167
ALA A1225
 ANP  A1358 (-4.4A)
ANP  A1358 ( 3.8A)
ANP  A1358 ( 4.1A)
None
None
None
 0.67A 4anqA-3plsA:
28.8		 4anqA-3plsA:
34.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 12 LEU A1276
LEU A1280
LEU A1281
THR A1181
VAL A1341
 None
 1.15A 4f4dA-3plsA:
undetectable		 4f4dA-3plsA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 12 LYS A1114
ASN A1213
ASP A1226
PHE A1227
GLY A1228
 ANP  A1358 (-3.2A)
MG  A   1 ( 2.9A)
MG  A   1 ( 3.2A)
None
None
 0.98A 4lmnA-3plsA:
24.3		 4lmnA-3plsA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		3 / 3 SER A1117
ASP A1226
ASP A1168
 None
MG  A   1 ( 3.2A)
ANP  A1358 (-4.1A)
 0.76A 4mwzA-3plsA:
undetectable		 4mwzA-3plsA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		4 / 6 VAL A1096
ALA A1112
LYS A1114
LEU A1144
 ANP  A1358 (-4.4A)
ANP  A1358 ( 3.8A)
ANP  A1358 (-3.2A)
None
 0.60A 4o0uA-3plsA:
7.8		 4o0uA-3plsA:
25.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		8 / 11 GLY A1091
VAL A1096
ALA A1112
TYR A1163
MET A1164
GLY A1167
ASN A1213
ALA A1225
 ANP  A1358 (-3.4A)
ANP  A1358 (-4.4A)
ANP  A1358 ( 3.8A)
ANP  A1358 (-4.3A)
None
None
MG  A   1 ( 2.9A)
None
 0.67A 4u5jA-3plsA:
30.4		 4u5jA-3plsA:
37.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A1096
ALA A1112
LEU A1199
HIS A1206
ALA A1225
GLY A1228
 ANP  A1358 (-4.4A)
ANP  A1358 ( 3.8A)
None
None
None
None
 0.72A 4v04A-3plsA:
30.2		 4v04A-3plsA:
39.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 12 ALA A1112
LEU A1199
HIS A1206
ALA A1225
GLY A1228
 ANP  A1358 ( 3.8A)
None
None
None
None
 0.71A 4v04B-3plsA:
30.7		 4v04B-3plsA:
39.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 11 LEU A1074
LEU A1151
GLU A1069
LEU A1129
LEU A1062
 None
 1.19A 4wg0F-3plsA:
undetectable
4wg0G-3plsA:
undetectable
4wg0H-3plsA:
undetectable		 4wg0F-3plsA:
5.69
4wg0G-3plsA:
5.69
4wg0H-3plsA:
5.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A1096
ALA A1112
LYS A1114
LEU A1144
ASP A1226
PHE A1227
 ANP  A1358 (-4.4A)
ANP  A1358 ( 3.8A)
ANP  A1358 (-3.2A)
None
MG  A   1 ( 3.2A)
None
 1.33A 4xv2A-3plsA:
27.7		 4xv2A-3plsA:
31.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A1096
ALA A1112
LYS A1114
LEU A1144
GLY A1167
ASP A1226
 ANP  A1358 (-4.4A)
ANP  A1358 ( 3.8A)
ANP  A1358 (-3.2A)
None
None
MG  A   1 ( 3.2A)
 0.84A 5h2uB-3plsA:
31.8		 5h2uB-3plsA:
38.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 9 ILE A1088
GLY A1089
VAL A1096
ALA A1112
MET A1164
 ANP  A1358 (-4.3A)
ANP  A1358 ( 3.7A)
ANP  A1358 (-4.4A)
ANP  A1358 ( 3.8A)
None
 0.76A 5lw1B-3plsA:
14.7		 5lw1B-3plsA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		3 / 3 MET A1320
GLN A1321
ARG A1305
 None
 1.12A 5m35B-3plsA:
3.0		 5m35B-3plsA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		3 / 3 MET A1320
GLN A1321
ARG A1305
 None
 1.12A 5m36A-3plsA:
undetectable		 5m36A-3plsA:
20.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A1096
ALA A1112
LYS A1114
MET A1135
GLY A1167
PHE A1227
 ANP  A1358 (-4.4A)
ANP  A1358 ( 3.8A)
ANP  A1358 (-3.2A)
None
None
None
 0.81A 5p9iA-3plsA:
32.3		 5p9iA-3plsA:
32.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 12 VAL A1096
ALA A1112
LYS A1114
GLY A1167
ASP A1226
 ANP  A1358 (-4.4A)
ANP  A1358 ( 3.8A)
ANP  A1358 (-3.2A)
None
MG  A   1 ( 3.2A)
 0.65A 5yu9C-3plsA:
30.4		 5yu9C-3plsA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A1096
ALA A1112
LYS A1114
GLY A1167
ASP A1226
LEU A1229
 ANP  A1358 (-4.4A)
ANP  A1358 ( 3.8A)
ANP  A1358 (-3.2A)
None
MG  A   1 ( 3.2A)
None
 0.65A 5yu9D-3plsA:
31.3		 5yu9D-3plsA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		4 / 5 LEU A1300
LEU A1306
THR A1254
ARG A1245
 None
 1.11A 6ew0F-3plsA:
undetectable		 6ew0F-3plsA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		4 / 6 LEU A1300
LEU A1306
THR A1254
ARG A1245
 None
 1.10A 6ew0G-3plsA:
undetectable		 6ew0G-3plsA:
15.44