SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3plw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3plw RECOMBINATION
ENHANCEMENT FUNCTION
PROTEIN
(Escherichia
virus
P1) 		3 / 3 GLN A 126
HIS A 123
ARG A  85
 None
 0.81A 1zlqA-3plwA:
undetectable		 1zlqA-3plwA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 3plw RECOMBINATION
ENHANCEMENT FUNCTION
PROTEIN
(Escherichia
virus
P1) 		4 / 6 PRO A 147
LEU A 166
ARG A 143
GLY A 159
 None
 1.22A 2hs2B-3plwA:
undetectable		 2hs2B-3plwA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 3plw RECOMBINATION
ENHANCEMENT FUNCTION
PROTEIN
(Escherichia
virus
P1) 		4 / 7 ALA A  98
PHE A 164
PRO A 128
LEU A 174
 ZN  A 188 ( 4.6A)
None
None
None
 0.73A 4du2A-3plwA:
undetectable		 4du2A-3plwA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 3plw RECOMBINATION
ENHANCEMENT FUNCTION
PROTEIN
(Escherichia
virus
P1) 		4 / 7 ALA A  98
PHE A 164
PRO A 128
LEU A 174
 ZN  A 188 ( 4.6A)
None
None
None
 0.71A 4du2B-3plwA:
undetectable		 4du2B-3plwA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 3plw RECOMBINATION
ENHANCEMENT FUNCTION
PROTEIN
(Escherichia
virus
P1) 		5 / 11 ILE A  97
LEU A  91
HIS A 112
LEU A 111
LEU A 175
 None
None
ZN  A 187 ( 3.1A)
None
None
 1.06A 4p65E-3plwA:
undetectable
4p65F-3plwA:
undetectable
4p65J-3plwA:
undetectable
4p65L-3plwA:
undetectable		 4p65E-3plwA:
8.20
4p65F-3plwA:
7.65
4p65J-3plwA:
7.65
4p65L-3plwA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3plw RECOMBINATION
ENHANCEMENT FUNCTION
PROTEIN
(Escherichia
virus
P1) 		5 / 12 ILE A 114
HIS A 133
CYH A  96
CYH A  99
LEU A 129
 None
ZN  A 188 (-3.2A)
ZN  A 188 (-2.3A)
ZN  A 188 (-2.2A)
None
 1.27A 6bp4B-3plwA:
undetectable		 6bp4B-3plwA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3plw RECOMBINATION
ENHANCEMENT FUNCTION
PROTEIN
(Escherichia
virus
P1) 		3 / 3 HIS A 112
HIS A 153
HIS A 134
 ZN  A 187 ( 3.1A)
ZN  A 187 ( 3.2A)
ZN  A 187 ( 3.2A)
 0.72A 6giqa-3plwA:
undetectable		 6giqa-3plwA:
14.58