SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pm6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 3pm6 PUTATIVE
FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Coccidioides
immitis) 		5 / 12 HIS A  84
ALA A 142
ASN A 245
ALA A  27
ILE A 289
 None
 1.15A 1kxhA-3pm6A:
5.6		 1kxhA-3pm6A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3pm6 PUTATIVE
FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Coccidioides
immitis) 		4 / 6 ARG A 209
ASN A 190
PRO A 186
ALA A 187
 IOD  A 308 ( 4.9A)
None
None
None
 1.37A 2ejfB-3pm6A:
undetectable		 2ejfB-3pm6A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3pm6 PUTATIVE
FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Coccidioides
immitis) 		4 / 7 ARG A 209
ASN A 190
PRO A 186
ALA A 187
 IOD  A 308 ( 4.9A)
None
None
None
 1.31A 2ejgA-3pm6A:
undetectable		 2ejgA-3pm6A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 3pm6 PUTATIVE
FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Coccidioides
immitis) 		5 / 12 HIS A  87
ILE A 150
GLY A 224
HIS A 223
ASP A  86
 ZN  A 319 (-3.3A)
None
None
ZN  A 319 (-3.2A)
ZN  A 319 ( 4.1A)
 1.12A 2pgfA-3pm6A:
8.8		 2pgfA-3pm6A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 3pm6 PUTATIVE
FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Coccidioides
immitis) 		5 / 12 HIS A  87
ILE A 150
GLY A 224
HIS A 223
ASP A  86
 ZN  A 319 (-3.3A)
None
None
ZN  A 319 (-3.2A)
ZN  A 319 ( 4.1A)
 1.14A 2pgrA-3pm6A:
3.9		 2pgrA-3pm6A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 3pm6 PUTATIVE
FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Coccidioides
immitis) 		4 / 5 SER A 118
LEU A 167
GLY A 165
GLU A 146
 None
 1.20A 3aiaA-3pm6A:
1.9
3aiaB-3pm6A:
undetectable		 3aiaA-3pm6A:
20.90
3aiaB-3pm6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 3pm6 PUTATIVE
FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Coccidioides
immitis) 		5 / 10 ALA A  58
LEU A  66
HIS A  84
LEU A  85
MET A 114
 None
 1.37A 3erdB-3pm6A:
undetectable		 3erdB-3pm6A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3pm6 PUTATIVE
FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Coccidioides
immitis) 		3 / 3 GLY A 189
PRO A 186
LEU A 207
 None
 0.56A 3hcpB-3pm6A:
undetectable		 3hcpB-3pm6A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 3pm6 PUTATIVE
FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Coccidioides
immitis) 		4 / 8 LEU A  12
THR A  82
TRP A 183
GLY A 219
 None
 0.91A 3ny4A-3pm6A:
undetectable		 3ny4A-3pm6A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3pm6 PUTATIVE
FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Coccidioides
immitis) 		4 / 6 ILE A 289
PHE A 228
HIS A  84
VAL A 157
 None
 1.22A 4a97I-3pm6A:
undetectable		 4a97I-3pm6A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 3pm6 PUTATIVE
FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Coccidioides
immitis) 		4 / 8 PRO A  56
ILE A  59
ILE A  93
ASP A  90
 IOD  A 303 ( 4.6A)
None
IOD  A 304 (-4.2A)
None
 0.83A 4dtaB-3pm6A:
undetectable		 4dtaB-3pm6A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 3pm6 PUTATIVE
FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Coccidioides
immitis) 		3 / 3 GLU A 146
THR A 160
HIS A 119
 None
 0.86A 4q15B-3pm6A:
undetectable		 4q15B-3pm6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WQP_A_NCAA302_0
(PROBABLE
DEHYDROGENASE)		 3pm6 PUTATIVE
FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Coccidioides
immitis) 		4 / 8 SER A 118
GLN A  89
MET A 114
HIS A 119
 None
 1.25A 5wqpA-3pm6A:
undetectable		 5wqpA-3pm6A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3pm6 PUTATIVE
FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Coccidioides
immitis) 		5 / 9 VAL A 200
LEU A 202
LEU A 222
THR A 229
CYH A 236
 None
 1.32A 6czmD-3pm6A:
undetectable
6czmE-3pm6A:
undetectable		 6czmD-3pm6A:
21.62
6czmE-3pm6A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3pm6 PUTATIVE
FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Coccidioides
immitis) 		5 / 10 VAL A 200
LEU A 202
LEU A 222
THR A 229
CYH A 236
 None
 1.31A 6czmE-3pm6A:
undetectable
6czmF-3pm6A:
undetectable		 6czmE-3pm6A:
21.62
6czmF-3pm6A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3pm6 PUTATIVE
FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Coccidioides
immitis) 		3 / 3 HIS A 223
HIS A  87
HIS A 192
 ZN  A 319 (-3.2A)
ZN  A 319 (-3.3A)
ZN  A 319 (-3.3A)
 0.63A 6giqa-3pm6A:
undetectable		 6giqa-3pm6A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3pm6 PUTATIVE
FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Coccidioides
immitis) 		3 / 3 HIS A 223
HIS A  87
HIS A 192
 ZN  A 319 (-3.2A)
ZN  A 319 (-3.3A)
ZN  A 319 (-3.3A)
 0.74A 6hu9a-3pm6A:
undetectable		 6hu9a-3pm6A:
20.23