SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pm8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3pm8 CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		4 / 5 ASP A 482
GLY A 472
VAL A 464
ILE A 485
 None
 0.95A 2aoiA-3pm8A:
undetectable		 2aoiA-3pm8A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 3pm8 CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		4 / 8 ASP A 501
GLY A 498
GLU A 499
ASN A 495
 NA  A 516 ( 3.9A)
None
None
CA  A 514 (-3.0A)
 0.77A 2dtjA-3pm8A:
undetectable
2dtjB-3pm8A:
undetectable		 2dtjA-3pm8A:
23.58
2dtjB-3pm8A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3pm8 CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		4 / 6 GLU A 352
ASN A 345
GLU A 371
VAL A 446
 None
 1.00A 4ejwB-3pm8A:
undetectable		 4ejwB-3pm8A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 3pm8 CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		4 / 7 ILE A 378
PHE A 431
LEU A 342
THR A 440
 None
 1.08A 4mmcA-3pm8A:
undetectable		 4mmcA-3pm8A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3pm8 CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		4 / 6 ILE A 378
PHE A 379
ILE A 402
LEU A 342
 None
 0.71A 4o8fB-3pm8A:
undetectable		 4o8fB-3pm8A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3pm8 CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		5 / 11 SER A 339
VAL A 414
ASN A 345
THR A 435
ILE A 395
 None
 1.26A 5y80A-3pm8A:
undetectable		 5y80A-3pm8A:
15.68