SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pmm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 3pmm PUTATIVE CYTOPLASMIC
PROTEIN
(Klebsiella
pneumoniae) 		4 / 7 ASP A  91
ASP A  88
TYR A  75
TYR A  78
 None
 1.40A 1cebA-3pmmA:
undetectable		 1cebA-3pmmA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IA0_B_TXLB502_1
(TUBULIN BETA CHAIN)		 3pmm PUTATIVE CYTOPLASMIC
PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 LEU A  24
PHE A 379
THR A 372
ARG A  29
GLY A  82
 None
 1.47A 1ia0B-3pmmA:
0.0		 1ia0B-3pmmA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUB_B_TXLB501_1
(TUBULIN)		 3pmm PUTATIVE CYTOPLASMIC
PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 LEU A  24
PHE A 379
THR A 372
ARG A  29
GLY A  82
 None
 1.47A 1tubB-3pmmA:
undetectable		 1tubB-3pmmA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3pmm PUTATIVE CYTOPLASMIC
PROTEIN
(Klebsiella
pneumoniae) 		4 / 8 TYR A 300
TRP A 234
LEU A 174
MET A 170
 None
None
None
FMT  A 388 (-4.3A)
 1.46A 1uw6A-3pmmA:
undetectable
1uw6B-3pmmA:
undetectable		 1uw6A-3pmmA:
20.56
1uw6B-3pmmA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3pmm PUTATIVE CYTOPLASMIC
PROTEIN
(Klebsiella
pneumoniae) 		4 / 8 TYR A 300
TRP A 234
LEU A 174
MET A 170
 None
None
None
FMT  A 388 (-4.3A)
 1.44A 1uw6D-3pmmA:
undetectable
1uw6E-3pmmA:
undetectable		 1uw6D-3pmmA:
20.56
1uw6E-3pmmA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3pmm PUTATIVE CYTOPLASMIC
PROTEIN
(Klebsiella
pneumoniae) 		4 / 8 TYR A 300
TRP A 234
LEU A 174
MET A 170
 None
None
None
FMT  A 388 (-4.3A)
 1.47A 1uw6G-3pmmA:
undetectable
1uw6H-3pmmA:
undetectable		 1uw6G-3pmmA:
20.56
1uw6H-3pmmA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3pmm PUTATIVE CYTOPLASMIC
PROTEIN
(Klebsiella
pneumoniae) 		4 / 8 TYR A 300
TRP A 234
LEU A 174
MET A 170
 None
None
None
FMT  A 388 (-4.3A)
 1.45A 1uw6P-3pmmA:
undetectable
1uw6Q-3pmmA:
undetectable		 1uw6P-3pmmA:
20.56
1uw6Q-3pmmA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3pmm PUTATIVE CYTOPLASMIC
PROTEIN
(Klebsiella
pneumoniae) 		4 / 8 TRP A 234
LEU A 174
MET A 170
TYR A 300
 None
None
FMT  A 388 (-4.3A)
None
 1.47A 1uw6P-3pmmA:
undetectable
1uw6T-3pmmA:
undetectable		 1uw6P-3pmmA:
20.56
1uw6T-3pmmA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3pmm PUTATIVE CYTOPLASMIC
PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 THR A 343
TYR A 289
TYR A 352
ILE A 355
LEU A 282
 None
 1.33A 1z9hA-3pmmA:
0.9		 1z9hA-3pmmA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3pmm PUTATIVE CYTOPLASMIC
PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 THR A 343
TYR A 289
TYR A 352
ILE A 355
LEU A 282
 None
 1.33A 1z9hB-3pmmA:
0.9		 1z9hB-3pmmA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3pmm PUTATIVE CYTOPLASMIC
PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 THR A 343
TYR A 289
TYR A 352
ILE A 355
LEU A 282
 None
 1.33A 1z9hC-3pmmA:
0.9		 1z9hC-3pmmA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_B_ANWB99_0
(PROTEIN S100-A13)		 3pmm PUTATIVE CYTOPLASMIC
PROTEIN
(Klebsiella
pneumoniae) 		4 / 8 MET A 366
ALA A 365
VAL A  31
THR A  32
 None
None
None
FMT  A 387 ( 4.5A)
 1.27A 2kotB-3pmmA:
undetectable		 2kotB-3pmmA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 3pmm PUTATIVE CYTOPLASMIC
PROTEIN
(Klebsiella
pneumoniae) 		4 / 6 LEU A  71
ILE A  90
ARG A 125
VAL A 189
 None
 1.01A 2ygoA-3pmmA:
undetectable		 2ygoA-3pmmA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KIV_A_ACAA100_1
(APOLIPOPROTEIN)		 3pmm PUTATIVE CYTOPLASMIC
PROTEIN
(Klebsiella
pneumoniae) 		4 / 7 ARG A 227
ASP A 284
PHE A 212
ARG A 225
 None
 1.33A 3kivA-3pmmA:
undetectable		 3kivA-3pmmA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3pmm PUTATIVE CYTOPLASMIC
PROTEIN
(Klebsiella
pneumoniae) 		5 / 9 ASP A  91
ILE A  90
THR A 115
GLN A  79
ARG A 376
 None
None
None
FMT  A 382 (-3.2A)
None
 1.41A 4acaB-3pmmA:
undetectable
4acaC-3pmmA:
undetectable		 4acaB-3pmmA:
21.40
4acaC-3pmmA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3pmm PUTATIVE CYTOPLASMIC
PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 MET A  86
ILE A  28
VAL A  31
ALA A 365
LEU A 371
 FMT  A 387 ( 4.1A)
None
None
None
None
 1.18A 4m11C-3pmmA:
undetectable		 4m11C-3pmmA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 3pmm PUTATIVE CYTOPLASMIC
PROTEIN
(Klebsiella
pneumoniae) 		3 / 3 GLU A 244
TYR A 300
GLU A 373
 FMT  A 382 ( 4.2A)
None
None
 0.70A 4ryaA-3pmmA:
undetectable		 4ryaA-3pmmA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3pmm PUTATIVE CYTOPLASMIC
PROTEIN
(Klebsiella
pneumoniae) 		4 / 5 SER A 134
ARG A  97
GLY A 101
GLU A 100
 None
None
FMT  A 386 (-4.4A)
None
 1.07A 5cdqA-3pmmA:
undetectable
5cdqB-3pmmA:
undetectable
5cdqC-3pmmA:
undetectable		 5cdqA-3pmmA:
20.53
5cdqB-3pmmA:
19.44
5cdqC-3pmmA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3pmm PUTATIVE CYTOPLASMIC
PROTEIN
(Klebsiella
pneumoniae) 		4 / 5 SER A 134
ARG A  97
GLY A 101
GLU A 100
 None
None
FMT  A 386 (-4.4A)
None
 1.08A 5cdqR-3pmmA:
undetectable
5cdqS-3pmmA:
undetectable
5cdqT-3pmmA:
undetectable		 5cdqR-3pmmA:
20.53
5cdqS-3pmmA:
19.44
5cdqT-3pmmA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3pmm PUTATIVE CYTOPLASMIC
PROTEIN
(Klebsiella
pneumoniae) 		4 / 8 LEU A 375
LEU A  27
ILE A  89
THR A  32
 None
None
None
FMT  A 387 ( 4.5A)
 1.01A 5ljbA-3pmmA:
undetectable		 5ljbA-3pmmA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 3pmm PUTATIVE CYTOPLASMIC
PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 GLN A  25
ALA A  26
LEU A 375
VAL A 327
PHE A  18
 None
 0.90A 5vlmG-3pmmA:
1.4		 5vlmG-3pmmA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 3pmm PUTATIVE CYTOPLASMIC
PROTEIN
(Klebsiella
pneumoniae) 		4 / 5 VAL A 173
THR A 168
VAL A 254
LEU A 243
 None
 0.93A 6bqgA-3pmmA:
undetectable		 6bqgA-3pmmA:
10.88