SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pmq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 3pmq DECAHEME CYTOCHROME
C MTRF
(Shewanella
oneidensis) 		3 / 3 THR A  95
PRO A  91
TYR A 184
 None
 0.81A 2dxrA-3pmqA:
undetectable		 2dxrA-3pmqA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 3pmq DECAHEME CYTOCHROME
C MTRF
(Shewanella
oneidensis) 		5 / 12 LEU A 366
ARG A 367
ALA A 325
ASP A 365
PHE A 323
 None
 1.23A 2ejtA-3pmqA:
undetectable		 2ejtA-3pmqA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 3pmq DECAHEME CYTOCHROME
C MTRF
(Shewanella
oneidensis) 		5 / 12 LEU A 366
ARG A 367
SER A 356
ALA A 325
ASP A 365
 None
 1.08A 2ejtA-3pmqA:
undetectable		 2ejtA-3pmqA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 3pmq DECAHEME CYTOCHROME
C MTRF
(Shewanella
oneidensis) 		5 / 12 LEU A 366
ARG A 367
SER A 356
ALA A 325
ASP A 365
 None
 1.07A 3axtA-3pmqA:
undetectable		 3axtA-3pmqA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 3pmq DECAHEME CYTOCHROME
C MTRF
(Shewanella
oneidensis) 		5 / 12 GLY A 625
GLY A 556
GLY A 627
THR A 555
ILE A 557
 None
 0.94A 3eluA-3pmqA:
undetectable		 3eluA-3pmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 3pmq DECAHEME CYTOCHROME
C MTRF
(Shewanella
oneidensis) 		5 / 12 GLY A 625
GLY A 556
GLY A 627
THR A 555
ILE A 557
 None
 0.94A 3elwA-3pmqA:
undetectable		 3elwA-3pmqA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 3pmq DECAHEME CYTOCHROME
C MTRF
(Shewanella
oneidensis) 		5 / 12 GLY A 625
GLY A 556
GLY A 627
THR A 555
ILE A 557
 None
 0.95A 3gczA-3pmqA:
undetectable		 3gczA-3pmqA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3pmq DECAHEME CYTOCHROME
C MTRF
(Shewanella
oneidensis) 		5 / 11 VAL A 211
PHE A 119
GLY A 156
GLY A 157
ILE A 168
 None
 1.05A 3owxA-3pmqA:
undetectable
3owxB-3pmqA:
undetectable		 3owxA-3pmqA:
17.86
3owxB-3pmqA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 3pmq DECAHEME CYTOCHROME
C MTRF
(Shewanella
oneidensis) 		4 / 8 THR A 579
LEU A 573
THR A 577
VAL A 605
 None
 0.69A 4ik7B-3pmqA:
undetectable		 4ik7B-3pmqA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3pmq DECAHEME CYTOCHROME
C MTRF
(Shewanella
oneidensis) 		4 / 5 ILE A 468
VAL A 467
CYH A 546
HIS A 527
 HEC  A 675 ( 4.2A)
HEC  A 677 (-4.4A)
HEC  A 677 (-1.8A)
HEC  A 675 ( 3.0A)
 0.90A 4rzvA-3pmqA:
undetectable		 4rzvA-3pmqA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JDC_D_6JPD302_1
(PTERIDINE REDUCTASE)		 3pmq DECAHEME CYTOCHROME
C MTRF
(Shewanella
oneidensis) 		5 / 11 SER A 100
VAL A 215
LEU A  89
PRO A  91
TRP A 175
 HEC  A 672 ( 4.3A)
None
None
None
None
 1.46A 5jdcA-3pmqA:
undetectable
5jdcD-3pmqA:
undetectable		 5jdcA-3pmqA:
17.41
5jdcD-3pmqA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 3pmq DECAHEME CYTOCHROME
C MTRF
(Shewanella
oneidensis) 		3 / 3 CYH A 115
LYS A 123
HIS A 122
 None
 1.12A 5js5A-3pmqA:
undetectable		 5js5A-3pmqA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UH6_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3pmq DECAHEME CYTOCHROME
C MTRF
(Shewanella
oneidensis) 		5 / 12 GLN A 494
LEU A 497
GLN A 496
ASN A 470
HIS A 524
 None
None
HEC  A 677 (-3.7A)
None
HEC  A 677 (-3.3A)
 1.27A 5uh6C-3pmqA:
2.0		 5uh6C-3pmqA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 3pmq DECAHEME CYTOCHROME
C MTRF
(Shewanella
oneidensis) 		5 / 12 GLY A 625
GLY A 556
GLY A 627
THR A 555
ILE A 557
 None
 1.04A 5wz1A-3pmqA:
undetectable		 5wz1A-3pmqA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 3pmq DECAHEME CYTOCHROME
C MTRF
(Shewanella
oneidensis) 		5 / 12 GLY A 625
GLY A 556
GLY A 627
THR A 555
ILE A 557
 None
 1.04A 5wz1C-3pmqA:
undetectable		 5wz1C-3pmqA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 3pmq DECAHEME CYTOCHROME
C MTRF
(Shewanella
oneidensis) 		5 / 12 GLY A 625
GLY A 556
GLY A 627
THR A 555
ILE A 557
 None
 1.04A 5wz1D-3pmqA:
undetectable		 5wz1D-3pmqA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 3pmq DECAHEME CYTOCHROME
C MTRF
(Shewanella
oneidensis) 		5 / 12 GLY A 625
GLY A 556
GLY A 627
THR A 555
ILE A 557
 None
 1.04A 5wz1E-3pmqA:
undetectable		 5wz1E-3pmqA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 3pmq DECAHEME CYTOCHROME
C MTRF
(Shewanella
oneidensis) 		5 / 12 GLY A 625
GLY A 556
GLY A 627
THR A 555
ILE A 557
 None
 1.04A 5wz1F-3pmqA:
undetectable		 5wz1F-3pmqA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 3pmq DECAHEME CYTOCHROME
C MTRF
(Shewanella
oneidensis) 		4 / 6 SER A 329
SER A 331
ALA A 341
SER A 402
 None
 0.80A 6bocA-3pmqA:
undetectable
6bocB-3pmqA:
undetectable
6bocC-3pmqA:
undetectable
6bocD-3pmqA:
undetectable		 6bocA-3pmqA:
3.17
6bocB-3pmqA:
3.17
6bocC-3pmqA:
3.17
6bocD-3pmqA:
3.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 3pmq DECAHEME CYTOCHROME
C MTRF
(Shewanella
oneidensis) 		4 / 6 SER A 331
ALA A 341
SER A 402
SER A 329
 None
 0.79A 6bocA-3pmqA:
undetectable
6bocB-3pmqA:
undetectable
6bocC-3pmqA:
undetectable
6bocD-3pmqA:
undetectable		 6bocA-3pmqA:
3.17
6bocB-3pmqA:
3.17
6bocC-3pmqA:
3.17
6bocD-3pmqA:
3.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 3pmq DECAHEME CYTOCHROME
C MTRF
(Shewanella
oneidensis) 		4 / 5 LEU A 434
THR A 345
PRO A 389
ARG A 367
 None
 1.36A 6ew0B-3pmqA:
undetectable		 6ew0B-3pmqA:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 3pmq DECAHEME CYTOCHROME
C MTRF
(Shewanella
oneidensis) 		4 / 5 LEU A 434
THR A 345
PRO A 389
ARG A 367
 None
 1.36A 6ew0D-3pmqA:
undetectable		 6ew0D-3pmqA:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 3pmq DECAHEME CYTOCHROME
C MTRF
(Shewanella
oneidensis) 		4 / 5 LEU A 434
THR A 345
PRO A 389
ARG A 367
 None
 1.36A 6ew0H-3pmqA:
undetectable		 6ew0H-3pmqA:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 3pmq DECAHEME CYTOCHROME
C MTRF
(Shewanella
oneidensis) 		4 / 5 LEU A 434
THR A 345
PRO A 389
ARG A 367
 None
 1.36A 6ew0I-3pmqA:
undetectable		 6ew0I-3pmqA:
6.75