SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pn1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 3pn1 DNA LIGASE
(Haemophilus
influenzae) 		4 / 8 GLU A 300
ILE A  98
PRO A 106
LEU A 109
 None
 0.89A 1hmyA-3pn1A:
undetectable		 1hmyA-3pn1A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 3pn1 DNA LIGASE
(Haemophilus
influenzae) 		4 / 6 SER A 217
THR A 216
ASN A 214
ASP A 212
 None
 1.31A 1mxdA-3pn1A:
undetectable		 1mxdA-3pn1A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 3pn1 DNA LIGASE
(Haemophilus
influenzae) 		4 / 8 LEU A 125
PRO A 165
VAL A 234
GLY A 233
 None
 1.01A 2qd5A-3pn1A:
undetectable		 2qd5A-3pn1A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3pn1 DNA LIGASE
(Haemophilus
influenzae) 		5 / 12 ILE A  98
GLU A 300
ALA A 242
LEU A 260
ILE A 292
 None
 1.25A 2xkwB-3pn1A:
undetectable		 2xkwB-3pn1A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_B_SALB1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3pn1 DNA LIGASE
(Haemophilus
influenzae) 		5 / 9 ARG A 209
THR A 136
VAL A 122
ALA A 204
ALA A 205
 None
 1.27A 3ax7B-3pn1A:
undetectable		 3ax7B-3pn1A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 3pn1 DNA LIGASE
(Haemophilus
influenzae) 		4 / 7 VAL A 171
LEU A 117
MET A  79
ILE A 228
 None
IVH  A 319 (-4.7A)
None
None
 0.90A 3gp0A-3pn1A:
undetectable		 3gp0A-3pn1A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 3pn1 DNA LIGASE
(Haemophilus
influenzae) 		5 / 12 GLU A 114
LYS A 116
GLU A 174
VAL A 289
LYS A 291
 IVH  A 319 (-3.6A)
IVH  A 319 (-3.7A)
IVH  A 319 (-2.9A)
IVH  A 319 (-4.4A)
IVH  A 319 (-3.0A)
 0.55A 3qwuA-3pn1A:
10.2		 3qwuA-3pn1A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_B_ADNB501_1
(DNA LIGASE)		 3pn1 DNA LIGASE
(Haemophilus
influenzae) 		5 / 11 GLU A 114
LYS A 116
ARG A 137
GLU A 174
LYS A 291
 IVH  A 319 (-3.6A)
IVH  A 319 (-3.7A)
None
IVH  A 319 (-2.9A)
IVH  A 319 (-3.0A)
 0.70A 3qwuB-3pn1A:
10.8		 3qwuB-3pn1A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_B_ADNB501_1
(DNA LIGASE)		 3pn1 DNA LIGASE
(Haemophilus
influenzae) 		5 / 11 GLU A 114
LYS A 116
GLU A 174
VAL A 289
LYS A 291
 IVH  A 319 (-3.6A)
IVH  A 319 (-3.7A)
IVH  A 319 (-2.9A)
IVH  A 319 (-4.4A)
IVH  A 319 (-3.0A)
 0.35A 3qwuB-3pn1A:
10.8		 3qwuB-3pn1A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3pn1 DNA LIGASE
(Haemophilus
influenzae) 		4 / 5 PHE A 111
ILE A  98
GLY A 263
ILE A 292
 None
 0.92A 5dzkd-3pn1A:
undetectable
5dzkk-3pn1A:
undetectable
5dzky-3pn1A:
undetectable		 5dzkd-3pn1A:
22.60
5dzkk-3pn1A:
22.67
5dzky-3pn1A:
1.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 3pn1 DNA LIGASE
(Haemophilus
influenzae) 		5 / 9 ILE A 258
PRO A 256
VAL A 171
ILE A 252
LEU A 260
 None
 1.32A 5iepA-3pn1A:
undetectable		 5iepA-3pn1A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 3pn1 DNA LIGASE
(Haemophilus
influenzae) 		5 / 9 PRO A 256
VAL A 171
LEU A 247
ILE A 252
LEU A 260
 None
 1.40A 5iepA-3pn1A:
undetectable		 5iepA-3pn1A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 3pn1 DNA LIGASE
(Haemophilus
influenzae) 		5 / 10 LEU A 281
ILE A 274
PRO A 115
PHE A 316
PRO A 200
 None
 1.34A 5m0oA-3pn1A:
undetectable		 5m0oA-3pn1A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 3pn1 DNA LIGASE
(Haemophilus
influenzae) 		4 / 8 LEU A 281
ILE A 274
PRO A 115
PHE A 316
 None
 1.06A 5m0oC-3pn1A:
undetectable		 5m0oC-3pn1A:
23.01