SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pnn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 3pnn CONSERVED DOMAIN
PROTEIN
(Porphyromonas
gingivalis) 		4 / 7 PHE A 248
ASN A 251
SER A 256
ARG A 258
 None
 1.46A 1rqpB-3pnnA:
undetectable		 1rqpB-3pnnA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 3pnn CONSERVED DOMAIN
PROTEIN
(Porphyromonas
gingivalis) 		5 / 11 GLY A  11
GLY A  13
ILE A  32
ALA A   9
ALA A 120
 GOL  A 302 (-3.6A)
None
GOL  A 301 (-4.4A)
None
None
 0.98A 1x7pA-3pnnA:
undetectable
1x7pB-3pnnA:
undetectable		 1x7pA-3pnnA:
21.35
1x7pB-3pnnA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3pnn CONSERVED DOMAIN
PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 GLY A  26
LEU A 286
GLY A 272
ALA A 120
ASP A  23
 None
None
GOL  A 303 ( 4.0A)
None
GOL  A 301 (-3.5A)
 1.05A 2bm9F-3pnnA:
undetectable		 2bm9F-3pnnA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 3pnn CONSERVED DOMAIN
PROTEIN
(Porphyromonas
gingivalis) 		4 / 7 PHE A 248
ASN A 251
SER A 256
ARG A 258
 None
 1.47A 2v7uB-3pnnA:
1.7		 2v7uB-3pnnA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 3pnn CONSERVED DOMAIN
PROTEIN
(Porphyromonas
gingivalis) 		3 / 3 TYR A  68
ASP A 121
ASP A  34
 None
GOL  A 301 ( 2.8A)
None
 0.85A 3r24A-3pnnA:
undetectable		 3r24A-3pnnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 3pnn CONSERVED DOMAIN
PROTEIN
(Porphyromonas
gingivalis) 		4 / 4 ILE A 111
VAL A  51
VAL A  49
ARG A  47
 None
 1.09A 4m6tA-3pnnA:
undetectable		 4m6tA-3pnnA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3pnn CONSERVED DOMAIN
PROTEIN
(Porphyromonas
gingivalis) 		4 / 6 ARG A 165
ASP A 122
VAL A 104
ALA A 103
 GOL  A 304 (-4.4A)
GOL  A 304 ( 3.1A)
None
None
 0.97A 4nkxA-3pnnA:
undetectable		 4nkxA-3pnnA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 3pnn CONSERVED DOMAIN
PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 ILE A  52
VAL A   7
ASP A 121
MET A  33
ILE A  64
 None
None
GOL  A 301 ( 2.8A)
None
None
 1.28A 4xe0A-3pnnA:
undetectable		 4xe0A-3pnnA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3pnn CONSERVED DOMAIN
PROTEIN
(Porphyromonas
gingivalis) 		3 / 3 ARG A 187
PHE A 194
LEU A 157
 None
 0.91A 5x1bC-3pnnA:
undetectable		 5x1bC-3pnnA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 3pnn CONSERVED DOMAIN
PROTEIN
(Porphyromonas
gingivalis) 		5 / 10 VAL A  51
LEU A  76
LEU A   5
PHE A  60
GLY A  11
 None
None
None
None
GOL  A 302 (-3.6A)
 1.21A 6eu9B-3pnnA:
undetectable		 6eu9B-3pnnA:
15.47