SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pnu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 3pnu DIHYDROOROTASE
(Campylobacter
jejuni) 		5 / 12 PHE A 269
LEU A 221
ALA A 225
VAL A 232
LEU A   3
 None
 1.01A 1cbrA-3pnuA:
undetectable		 1cbrA-3pnuA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 3pnu DIHYDROOROTASE
(Campylobacter
jejuni) 		5 / 12 PHE A 269
LEU A 221
ALA A 225
VAL A 232
LEU A   3
 None
 1.01A 1cbrB-3pnuA:
undetectable		 1cbrB-3pnuA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 3pnu DIHYDROOROTASE
(Campylobacter
jejuni) 		4 / 5 HIS A  10
HIS A 131
HIS A 165
ASP A 237
 ZN  A 337 (-3.3A)
ZN  A 336 (-3.1A)
ZN  A 336 (-3.2A)
ZN  A 337 (-2.9A)
 0.60A 1e9yB-3pnuA:
16.4		 1e9yB-3pnuA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 3pnu DIHYDROOROTASE
(Campylobacter
jejuni) 		5 / 6 HIS A  10
HIS A  12
HIS A 131
HIS A 165
ASP A 237
 ZN  A 337 (-3.3A)
ZN  A 337 (-3.4A)
ZN  A 336 (-3.1A)
ZN  A 336 (-3.2A)
ZN  A 337 (-2.9A)
 0.65A 1fweC-3pnuA:
5.4		 1fweC-3pnuA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 3pnu DIHYDROOROTASE
(Campylobacter
jejuni) 		4 / 6 LEU A 181
MET A 163
LEU A 171
GLU A 150
 None
 1.14A 2kuhA-3pnuA:
undetectable		 2kuhA-3pnuA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 3pnu DIHYDROOROTASE
(Campylobacter
jejuni) 		3 / 3 GLU A 164
HIS A  10
THR A 184
 None
ZN  A 337 (-3.3A)
None
 0.87A 3hkuA-3pnuA:
undetectable		 3hkuA-3pnuA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 3pnu DIHYDROOROTASE
(Campylobacter
jejuni) 		5 / 12 ASP A 237
HIS A  10
HIS A  12
ALA A 253
CYH A 208
 ZN  A 337 (-2.9A)
ZN  A 337 (-3.3A)
ZN  A 337 (-3.4A)
None
None
 1.02A 3r2jC-3pnuA:
undetectable		 3r2jC-3pnuA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3pnu DIHYDROOROTASE
(Campylobacter
jejuni) 		4 / 8 ILE A  91
LEU A 128
VAL A 106
GLY A 105
 KCX  A  92 ( 4.0A)
None
None
None
 0.90A 3w1wA-3pnuA:
undetectable		 3w1wA-3pnuA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3pnu DIHYDROOROTASE
(Campylobacter
jejuni) 		4 / 7 GLY A  90
THR A  70
ILE A  88
PHE A  80
 None
KCX  A  92 ( 4.7A)
None
None
 0.95A 4acaC-3pnuA:
2.1		 4acaC-3pnuA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 3pnu DIHYDROOROTASE
(Campylobacter
jejuni) 		4 / 4 SER A 107
TYR A 113
GLY A 105
PRO A  95
 None
 1.18A 4e3aA-3pnuA:
undetectable		 4e3aA-3pnuA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_C_ACTC506_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3pnu DIHYDROOROTASE
(Campylobacter
jejuni) 		4 / 5 ARG A 141
ILE A  98
HIS A 131
GLY A 132
 None
None
ZN  A 336 (-3.1A)
None
 1.29A 4e7cC-3pnuA:
undetectable		 4e7cC-3pnuA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 3pnu DIHYDROOROTASE
(Campylobacter
jejuni) 		4 / 5 HIS A  10
HIS A 131
HIS A 165
ASP A 237
 ZN  A 337 (-3.3A)
ZN  A 336 (-3.1A)
ZN  A 336 (-3.2A)
ZN  A 337 (-2.9A)
 0.62A 4h9mA-3pnuA:
5.0		 4h9mA-3pnuA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 3pnu DIHYDROOROTASE
(Campylobacter
jejuni) 		5 / 6 HIS A  10
HIS A  12
HIS A 131
HIS A 165
ASP A 237
 ZN  A 337 (-3.3A)
ZN  A 337 (-3.4A)
ZN  A 336 (-3.1A)
ZN  A 336 (-3.2A)
ZN  A 337 (-2.9A)
 0.49A 4ubpC-3pnuA:
18.0		 4ubpC-3pnuA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3pnu DIHYDROOROTASE
(Campylobacter
jejuni) 		4 / 8 THR A 117
LEU A 118
LEU A  93
LEU A 128
 None
None
KCX  A  92 ( 4.6A)
None
 0.63A 4z90F-3pnuA:
undetectable
4z90G-3pnuA:
undetectable
4z90H-3pnuA:
undetectable
4z90I-3pnuA:
undetectable
4z90J-3pnuA:
undetectable		 4z90F-3pnuA:
20.25
4z90G-3pnuA:
20.25
4z90H-3pnuA:
20.25
4z90I-3pnuA:
20.25
4z90J-3pnuA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3pnu DIHYDROOROTASE
(Campylobacter
jejuni) 		5 / 10 LEU A  93
LEU A 128
THR A 117
LEU A 118
LEU A 114
 KCX  A  92 ( 4.6A)
None
None
None
None
 0.95A 4z91A-3pnuA:
undetectable
4z91B-3pnuA:
undetectable
4z91C-3pnuA:
undetectable
4z91D-3pnuA:
undetectable
4z91E-3pnuA:
undetectable		 4z91A-3pnuA:
20.25
4z91B-3pnuA:
20.25
4z91C-3pnuA:
20.25
4z91D-3pnuA:
20.25
4z91E-3pnuA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3pnu DIHYDROOROTASE
(Campylobacter
jejuni) 		5 / 10 LEU A  93
LEU A 128
THR A 117
LEU A 118
LEU A 114
 KCX  A  92 ( 4.6A)
None
None
None
None
 0.97A 4z91A-3pnuA:
undetectable
4z91B-3pnuA:
undetectable
4z91C-3pnuA:
undetectable
4z91D-3pnuA:
undetectable
4z91E-3pnuA:
undetectable		 4z91A-3pnuA:
20.25
4z91B-3pnuA:
20.25
4z91C-3pnuA:
20.25
4z91D-3pnuA:
20.25
4z91E-3pnuA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3pnu DIHYDROOROTASE
(Campylobacter
jejuni) 		5 / 10 LEU A 114
LEU A  93
LEU A 128
THR A 117
LEU A 118
 None
KCX  A  92 ( 4.6A)
None
None
None
 0.94A 4z91A-3pnuA:
undetectable
4z91B-3pnuA:
undetectable
4z91C-3pnuA:
undetectable
4z91D-3pnuA:
undetectable
4z91E-3pnuA:
undetectable		 4z91A-3pnuA:
20.25
4z91B-3pnuA:
20.25
4z91C-3pnuA:
20.25
4z91D-3pnuA:
20.25
4z91E-3pnuA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3pnu DIHYDROOROTASE
(Campylobacter
jejuni) 		5 / 10 LEU A 128
THR A 117
LEU A 118
LEU A 114
LEU A  93
 None
None
None
None
KCX  A  92 ( 4.6A)
 0.98A 4z91A-3pnuA:
undetectable
4z91B-3pnuA:
undetectable
4z91C-3pnuA:
undetectable
4z91D-3pnuA:
undetectable
4z91E-3pnuA:
undetectable		 4z91A-3pnuA:
20.25
4z91B-3pnuA:
20.25
4z91C-3pnuA:
20.25
4z91D-3pnuA:
20.25
4z91E-3pnuA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3pnu DIHYDROOROTASE
(Campylobacter
jejuni) 		5 / 10 THR A 117
LEU A 118
LEU A 114
LEU A  93
LEU A 128
 None
None
None
KCX  A  92 ( 4.6A)
None
 0.96A 4z91A-3pnuA:
undetectable
4z91B-3pnuA:
undetectable
4z91C-3pnuA:
undetectable
4z91D-3pnuA:
undetectable
4z91E-3pnuA:
undetectable		 4z91A-3pnuA:
20.25
4z91B-3pnuA:
20.25
4z91C-3pnuA:
20.25
4z91D-3pnuA:
20.25
4z91E-3pnuA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3pnu DIHYDROOROTASE
(Campylobacter
jejuni) 		4 / 8 ASP A 237
HIS A  12
ARG A 141
HIS A 165
 ZN  A 337 (-2.9A)
ZN  A 337 (-3.4A)
None
ZN  A 336 (-3.2A)
 0.88A 5nekB-3pnuA:
undetectable		 5nekB-3pnuA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3pnu DIHYDROOROTASE
(Campylobacter
jejuni) 		5 / 8 ASP A 237
HIS A 165
HIS A 131
PRO A 210
HIS A  12
 ZN  A 337 (-2.9A)
ZN  A 336 (-3.2A)
ZN  A 336 (-3.1A)
None
ZN  A 337 (-3.4A)
 1.40A 5nekB-3pnuA:
undetectable		 5nekB-3pnuA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 3pnu DIHYDROOROTASE
(Campylobacter
jejuni) 		4 / 6 PRO A   6
LEU A   7
PHE A 234
LEU A   3
 None
 1.12A 5tl8A-3pnuA:
undetectable		 5tl8A-3pnuA:
22.38