SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pnx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 3pnx PUTATIVE
SULFURTRANSFERASE
DSRE
(Syntrophomonas
wolfei) 		4 / 7 SER A 104
ASP A 105
GLU A  72
GLU A  51
 None
 1.15A 1knyA-3pnxA:
undetectable
1knyB-3pnxA:
undetectable		 1knyA-3pnxA:
19.92
1knyB-3pnxA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 3pnx PUTATIVE
SULFURTRANSFERASE
DSRE
(Syntrophomonas
wolfei) 		4 / 8 SER A 104
ASP A 105
GLU A  72
GLU A  51
 None
 1.07A 1knyA-3pnxA:
undetectable
1knyB-3pnxA:
undetectable		 1knyA-3pnxA:
19.92
1knyB-3pnxA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3pnx PUTATIVE
SULFURTRANSFERASE
DSRE
(Syntrophomonas
wolfei) 		5 / 7 LEU A  46
ALA A 110
ALA A  25
LEU A  10
ALA A  18
 None
 1.17A 4z90F-3pnxA:
undetectable
4z90G-3pnxA:
undetectable
4z90H-3pnxA:
undetectable
4z90J-3pnxA:
undetectable		 4z90F-3pnxA:
19.50
4z90G-3pnxA:
19.50
4z90H-3pnxA:
19.50
4z90J-3pnxA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 3pnx PUTATIVE
SULFURTRANSFERASE
DSRE
(Syntrophomonas
wolfei) 		5 / 9 ALA A  18
LEU A  45
GLY A  43
LEU A  46
LEU A 103
 None
 0.94A 5dqfA-3pnxA:
undetectable		 5dqfA-3pnxA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3pnx PUTATIVE
SULFURTRANSFERASE
DSRE
(Syntrophomonas
wolfei) 		5 / 12 VAL A 124
MET A 127
GLY A  43
LEU A  22
LEU A 107
 OCS  A 120 ( 3.8A)
None
None
None
None
 1.47A 5x23A-3pnxA:
undetectable		 5x23A-3pnxA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 3pnx PUTATIVE
SULFURTRANSFERASE
DSRE
(Syntrophomonas
wolfei) 		4 / 8 LYS A  17
ALA A  18
GLY A  43
LEU A  46
 None
 0.78A 6mdqA-3pnxA:
undetectable		 6mdqA-3pnxA:
20.83