SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pov'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 3pov ORF 37
(Human
gammaherpesvirus
8) 		5 / 12 LEU A 453
LEU A 478
ILE A 143
GLY A 217
SER A 210
 None
 0.91A 1cqeA-3povA:
undetectable		 1cqeA-3povA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 3pov ORF 37
(Human
gammaherpesvirus
8) 		5 / 12 LEU A 453
LEU A 478
ILE A 143
GLY A 217
SER A 210
 None
 0.91A 1cqeB-3povA:
undetectable		 1cqeB-3povA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_B_CAMB502_0
(CYTOCHROME P450-CAM)		 3pov ORF 37
(Human
gammaherpesvirus
8) 		4 / 5 PHE A 408
TYR A 251
VAL A 289
VAL A 342
 None
 1.30A 1dz6B-3povA:
undetectable		 1dz6B-3povA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 3pov ORF 37
(Human
gammaherpesvirus
8) 		5 / 12 GLY A  22
ASN A 132
SER A 128
GLY A  79
ILE A  78
 None
 1.12A 1q8jB-3povA:
undetectable		 1q8jB-3povA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 3pov ORF 37
(Human
gammaherpesvirus
8) 		3 / 3 ALA A  33
VAL A 134
TRP A 135
 None
 0.99A 1tkqA-3povA:
undetectable		 1tkqA-3povA:
3.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3pov ORF 37
(Human
gammaherpesvirus
8) 		5 / 12 LEU A 453
LEU A 478
ILE A 143
GLY A 217
SER A 210
 None
 0.82A 2aylB-3povA:
undetectable		 2aylB-3povA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3pov ORF 37
(Human
gammaherpesvirus
8) 		5 / 12 ALA A 288
ILE A 438
LEU A 195
GLY A 407
PHE A 408
 None
 1.09A 3k2hA-3povA:
undetectable		 3k2hA-3povA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3pov ORF 37
(Human
gammaherpesvirus
8) 		5 / 12 ALA A 288
ILE A 438
LEU A 195
GLY A 407
PHE A 408
 None
 1.08A 3k2hB-3povA:
undetectable		 3k2hB-3povA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3pov ORF 37
(Human
gammaherpesvirus
8) 		5 / 12 LEU A 453
LEU A 478
ILE A 143
GLY A 217
SER A 210
 None
 0.80A 3n8xB-3povA:
undetectable		 3n8xB-3povA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3pov ORF 37
(Human
gammaherpesvirus
8) 		3 / 3 HIS A 454
SER A 461
ASN A 213
 None
 0.85A 3s8pB-3povA:
undetectable		 3s8pB-3povA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 3pov ORF 37
(Human
gammaherpesvirus
8) 		4 / 8 ARG A 319
LEU A 297
ARG A 370
GLU A 300
 None
 1.44A 3zmdA-3povA:
undetectable
3zmdB-3povA:
undetectable		 3zmdA-3povA:
14.61
3zmdB-3povA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 3pov ORF 37
(Human
gammaherpesvirus
8) 		5 / 11 HIS A 196
LEU A 181
ASP A 204
LEU A 203
PHE A 222
 None
 1.49A 4foxC-3povA:
undetectable		 4foxC-3povA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3pov ORF 37
(Human
gammaherpesvirus
8) 		4 / 7 PHE A 280
GLU A 270
ARG A 410
VAL A 344
 None
 1.43A 4jseA-3povA:
undetectable
4jseB-3povA:
undetectable		 4jseA-3povA:
22.39
4jseB-3povA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 3pov ORF 37
(Human
gammaherpesvirus
8) 		5 / 9 LEU A 453
ALA A 456
GLN A 376
PHE A 148
TYR A 375
 None
 1.40A 4ltwA-3povA:
undetectable		 4ltwA-3povA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3pov ORF 37
(Human
gammaherpesvirus
8) 		5 / 9 ALA A 448
ASN A 368
VAL A 367
SER A 381
VAL A 442
 None
 1.12A 4r20B-3povA:
undetectable		 4r20B-3povA:
20.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HSW_A_ACTA501_0
(ORF 37)		 3pov ORF 37
(Human
gammaherpesvirus
8) 		4 / 5 SER A 144
SER A 145
SER A 146
SER A 219
 FMT  A 489 ( 4.6A)
FMT  A 489 (-2.5A)
None
None
 0.64A 5hswA-3povA:
53.5		 5hswA-3povA:
99.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 3pov ORF 37
(Human
gammaherpesvirus
8) 		5 / 12 VAL A 439
ASP A 341
PHE A 222
THR A 200
ARG A 360
 None
 1.50A 5m54B-3povA:
undetectable		 5m54B-3povA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 3pov ORF 37
(Human
gammaherpesvirus
8) 		3 / 3 LEU A 478
SER A 476
PHE A 475
 None
 0.64A 6fgcA-3povA:
undetectable		 6fgcA-3povA:
20.93