SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pp6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 3pp6 SODIUM-CALCIUM
EXCHANGER
(Doryteuthis
pealeii) 		5 / 12 PHE A  17
TYR A  20
ALA A  34
PRO A  39
THR A  54
 None
None
PAM  A 133 ( 3.7A)
PAM  A 133 (-4.4A)
PAM  A 133 ( 3.9A)
 0.98A 1mx8A-3pp6A:
17.7		 1mx8A-3pp6A:
35.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3pp6 SODIUM-CALCIUM
EXCHANGER
(Doryteuthis
pealeii) 		4 / 8 THR A  75
VAL A  26
GLY A  25
VAL A 119
 None
 0.83A 2a1oA-3pp6A:
undetectable		 2a1oA-3pp6A:
15.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3pp6 SODIUM-CALCIUM
EXCHANGER
(Doryteuthis
pealeii) 		7 / 12 PHE A  17
VAL A  26
ALA A  34
THR A  61
ASP A  77
ARG A  79
ARG A 126
 None
None
PAM  A 133 ( 3.7A)
PAM  A 133 (-3.7A)
PAM  A 133 (-4.3A)
None
PAM  A 133 (-3.9A)
 0.26A 2qm9A-3pp6A:
23.1		 2qm9A-3pp6A:
37.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3pp6 SODIUM-CALCIUM
EXCHANGER
(Doryteuthis
pealeii) 		6 / 12 PHE A  17
TYR A  20
VAL A  26
THR A  61
ARG A  79
ARG A 126
 None
None
None
PAM  A 133 (-3.7A)
None
PAM  A 133 (-3.9A)
 0.43A 2qm9B-3pp6A:
23.8		 2qm9B-3pp6A:
37.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_2
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3pp6 SODIUM-CALCIUM
EXCHANGER
(Doryteuthis
pealeii) 		4 / 4 MET A  21
PRO A  39
ASP A  77
ARG A 106
 PAM  A 133 ( 3.9A)
PAM  A 133 (-4.4A)
PAM  A 133 (-4.3A)
None
 0.39A 2qm9B-3pp6A:
23.8		 2qm9B-3pp6A:
37.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3pp6 SODIUM-CALCIUM
EXCHANGER
(Doryteuthis
pealeii) 		8 / 12 PHE A  17
MET A  21
VAL A  26
PRO A  39
ASP A  77
ARG A  79
ARG A 106
ARG A 126
 None
PAM  A 133 ( 3.9A)
None
PAM  A 133 (-4.4A)
PAM  A 133 (-4.3A)
None
None
PAM  A 133 (-3.9A)
 0.44A 3p6gA-3pp6A:
23.1		 3p6gA-3pp6A:
42.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3pp6 SODIUM-CALCIUM
EXCHANGER
(Doryteuthis
pealeii) 		6 / 12 PHE A  17
MET A  21
VAL A  26
PRO A  39
CYH A 124
ARG A 126
 None
PAM  A 133 ( 3.9A)
None
PAM  A 133 (-4.4A)
None
PAM  A 133 (-3.9A)
 1.08A 3p6gA-3pp6A:
23.1		 3p6gA-3pp6A:
42.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3pp6 SODIUM-CALCIUM
EXCHANGER
(Doryteuthis
pealeii) 		5 / 12 PHE A  17
VAL A  24
PRO A  39
CYH A 124
ARG A 126
 None
None
PAM  A 133 (-4.4A)
None
PAM  A 133 (-3.9A)
 1.37A 3p6gA-3pp6A:
23.1		 3p6gA-3pp6A:
42.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3pp6 SODIUM-CALCIUM
EXCHANGER
(Doryteuthis
pealeii) 		4 / 7 PHE A  17
MET A  21
ASP A  77
ARG A 126
 None
PAM  A 133 ( 3.9A)
PAM  A 133 (-4.3A)
PAM  A 133 (-3.9A)
 0.44A 3p6hA-3pp6A:
23.1		 3p6hA-3pp6A:
42.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 3pp6 SODIUM-CALCIUM
EXCHANGER
(Doryteuthis
pealeii) 		4 / 8 GLN A  96
PHE A  71
THR A  54
THR A  61
 None
None
PAM  A 133 ( 3.9A)
PAM  A 133 (-3.7A)
 0.91A 4n16A-3pp6A:
undetectable		 4n16A-3pp6A:
16.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 3pp6 SODIUM-CALCIUM
EXCHANGER
(Doryteuthis
pealeii) 		4 / 6 TYR A  20
GLU A  73
THR A  75
GLN A  96
 None
 0.61A 4qztA-3pp6A:
21.7		 4qztA-3pp6A:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)		 3pp6 SODIUM-CALCIUM
EXCHANGER
(Doryteuthis
pealeii) 		5 / 6 TYR A  20
GLU A  73
THR A  75
GLN A  96
LEU A 117
 None
 0.58A 4qzuC-3pp6A:
21.7		 4qzuC-3pp6A:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 3pp6 SODIUM-CALCIUM
EXCHANGER
(Doryteuthis
pealeii) 		5 / 12 PHE A  17
MET A  21
ALA A  34
THR A  54
LEU A 117
 None
PAM  A 133 ( 3.9A)
PAM  A 133 ( 3.7A)
PAM  A 133 ( 3.9A)
None
 0.66A 4qzuC-3pp6A:
21.7		 4qzuC-3pp6A:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3pp6 SODIUM-CALCIUM
EXCHANGER
(Doryteuthis
pealeii) 		6 / 12 PHE A  17
TYR A  20
VAL A  26
ALA A  34
PRO A  39
ILE A  52
 None
None
None
PAM  A 133 ( 3.7A)
PAM  A 133 (-4.4A)
None
 0.73A 5hbsA-3pp6A:
21.0		 5hbsA-3pp6A:
36.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 3pp6 SODIUM-CALCIUM
EXCHANGER
(Doryteuthis
pealeii) 		4 / 7 THR A  56
LYS A  22
ASN A  35
GLU A  15
 PAM  A 133 ( 4.6A)
None
None
None
 0.87A 5tudA-3pp6A:
undetectable		 5tudA-3pp6A:
15.94