SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pp7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3pp7 PYRUVATE KINASE
(Leishmania
mexicana) 		3 / 3 VAL A 461
ALA A 458
HIS A 455
 None
 0.75A 1q23C-3pp7A:
undetectable		 1q23C-3pp7A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3pp7 PYRUVATE KINASE
(Leishmania
mexicana) 		3 / 3 VAL A 461
ALA A 458
HIS A 455
 None
 0.75A 1q23H-3pp7A:
undetectable		 1q23H-3pp7A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3pp7 PYRUVATE KINASE
(Leishmania
mexicana) 		3 / 3 VAL A 461
ALA A 458
HIS A 455
 None
 0.78A 1q23L-3pp7A:
undetectable		 1q23L-3pp7A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3pp7 PYRUVATE KINASE
(Leishmania
mexicana) 		4 / 5 GLY A 119
HIS A 169
ASP A 145
ASP A 173
 None
 1.11A 2oxtB-3pp7A:
undetectable		 2oxtB-3pp7A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 3pp7 PYRUVATE KINASE
(Leishmania
mexicana) 		4 / 7 VAL A  34
LYS A  38
ILE A  41
GLY A  44
 None
 0.87A 3bjwB-3pp7A:
undetectable		 3bjwB-3pp7A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 3pp7 PYRUVATE KINASE
(Leishmania
mexicana) 		4 / 7 LYS A  38
ILE A  41
GLN A  42
GLY A  44
 None
 0.84A 3bjwF-3pp7A:
undetectable		 3bjwF-3pp7A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3pp7 PYRUVATE KINASE
(Leishmania
mexicana) 		5 / 11 SER A 283
ILE A 282
VAL A 292
VAL A 260
ILE A 252
 None
 1.14A 3rf4A-3pp7A:
undetectable
3rf4C-3pp7A:
undetectable		 3rf4A-3pp7A:
11.64
3rf4C-3pp7A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3pp7 PYRUVATE KINASE
(Leishmania
mexicana) 		5 / 11 ILE A 252
SER A 283
ILE A 282
VAL A 292
VAL A 260
 None
 1.17A 3rf4A-3pp7A:
undetectable
3rf4B-3pp7A:
undetectable		 3rf4A-3pp7A:
11.64
3rf4B-3pp7A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3pp7 PYRUVATE KINASE
(Leishmania
mexicana) 		5 / 11 ILE A 252
SER A 283
ILE A 282
VAL A 292
VAL A 260
 None
 1.18A 3rf4B-3pp7A:
undetectable
3rf4C-3pp7A:
undetectable		 3rf4B-3pp7A:
11.64
3rf4C-3pp7A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 3pp7 PYRUVATE KINASE
(Leishmania
mexicana) 		5 / 11 GLY A 257
GLN A 430
MET A 207
PHE A 209
ILE A 293
 None
 1.46A 4j4vA-3pp7A:
undetectable		 4j4vA-3pp7A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3pp7 PYRUVATE KINASE
(Leishmania
mexicana) 		5 / 12 ALA A 295
SER A 301
THR A 309
GLU A 332
SER A 330
 None
 1.23A 5hfjE-3pp7A:
undetectable		 5hfjE-3pp7A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3pp7 PYRUVATE KINASE
(Leishmania
mexicana) 		4 / 5 SER A 405
ALA A 406
GLN A 430
THR A 434
 None
 1.40A 5n0tA-3pp7A:
2.5		 5n0tA-3pp7A:
24.52