SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pp8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 3pp8 GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE A
(Salmonella
enterica) 		5 / 12 SER A 254
PHE A 253
LEU A 223
LEU A 225
TYR A 102
 None
 1.25A 1p33C-3pp8A:
7.0		 1p33C-3pp8A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 3pp8 GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE A
(Salmonella
enterica) 		4 / 6 LEU A  71
LEU A  87
PRO A  47
VAL A  44
 None
 0.98A 2dqyC-3pp8A:
undetectable		 2dqyC-3pp8A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 3pp8 GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE A
(Salmonella
enterica) 		3 / 3 LYS A 170
ARG A 167
VAL A 179
 None
 1.10A 2r2vC-3pp8A:
undetectable
2r2vD-3pp8A:
undetectable		 2r2vC-3pp8A:
8.44
2r2vD-3pp8A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 3pp8 GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE A
(Salmonella
enterica) 		5 / 10 ILE A 207
GLY A 180
GLN A 203
THR A 204
ARG A 167
 None
 1.18A 2wd9C-3pp8A:
5.9		 2wd9C-3pp8A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 3pp8 GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE A
(Salmonella
enterica) 		5 / 12 ILE A   3
ASP A  40
ILE A 289
ILE A 293
GLU A 297
 None
 1.30A 2yzqA-3pp8A:
undetectable		 2yzqA-3pp8A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3pp8 GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE A
(Salmonella
enterica) 		5 / 12 GLY A 304
LEU A  43
ILE A 286
ASP A 287
LEU A  63
 None
 1.11A 2zbpA-3pp8A:
4.7		 2zbpA-3pp8A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 3pp8 GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE A
(Salmonella
enterica) 		5 / 12 GLY A 143
VAL A 151
LEU A 155
THR A 191
PHE A 187
 None
 1.37A 3mnpA-3pp8A:
undetectable		 3mnpA-3pp8A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3pp8 GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE A
(Salmonella
enterica) 		6 / 12 LEU A 225
GLY A 143
GLY A 148
ILE A 195
LEU A 198
PRO A 199
 None
 1.40A 4gc9A-3pp8A:
undetectable		 4gc9A-3pp8A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 3pp8 GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE A
(Salmonella
enterica) 		3 / 3 ASP A 241
ARG A 266
PRO A 263
 None
 1.00A 4wanC-3pp8A:
undetectable		 4wanC-3pp8A:
16.30