SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ppb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 3ppb PUTATIVE TETR FAMILY
TRANSCRIPTION
REGULATOR
(Shewanella
loihica) 		5 / 12 PHE A 187
LEU A  81
ALA A  85
LEU A  88
ILE A 135
 PG4  A 216 (-4.7A)
None
PG4  A 216 ( 4.1A)
PG4  A 216 (-3.8A)
None
 0.90A 1crbA-3ppbA:
undetectable		 1crbA-3ppbA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 3ppb PUTATIVE TETR FAMILY
TRANSCRIPTION
REGULATOR
(Shewanella
loihica) 		5 / 12 PHE A 187
LEU A  81
ALA A  85
MET A 124
ILE A 135
 PG4  A 216 (-4.7A)
None
PG4  A 216 ( 4.1A)
None
None
 1.08A 1crbA-3ppbA:
undetectable		 1crbA-3ppbA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3ppb PUTATIVE TETR FAMILY
TRANSCRIPTION
REGULATOR
(Shewanella
loihica) 		5 / 12 LEU A  55
LEU A  20
ALA A  35
GLU A  37
ALA A  12
 None
 1.00A 3mdvB-3ppbA:
undetectable		 3mdvB-3ppbA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 3ppb PUTATIVE TETR FAMILY
TRANSCRIPTION
REGULATOR
(Shewanella
loihica) 		3 / 3 TRP A  95
GLN A  87
THR A  94
 EDO  A 210 (-4.3A)
None
PG4  A 218 ( 4.9A)
 0.93A 4m2xA-3ppbA:
undetectable		 4m2xA-3ppbA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3ppb PUTATIVE TETR FAMILY
TRANSCRIPTION
REGULATOR
(Shewanella
loihica) 		5 / 12 PHE A 187
LEU A  81
ALA A  85
MET A 124
ILE A 135
 PG4  A 216 (-4.7A)
None
PG4  A 216 ( 4.1A)
None
None
 1.12A 5h8tA-3ppbA:
undetectable		 5h8tA-3ppbA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3ppb PUTATIVE TETR FAMILY
TRANSCRIPTION
REGULATOR
(Shewanella
loihica) 		5 / 12 PHE A 187
LEU A  81
ALA A  85
MET A 124
ILE A 135
 PG4  A 216 (-4.7A)
None
PG4  A 216 ( 4.1A)
None
None
 1.12A 5hbsA-3ppbA:
undetectable		 5hbsA-3ppbA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3ppb PUTATIVE TETR FAMILY
TRANSCRIPTION
REGULATOR
(Shewanella
loihica) 		5 / 12 PHE A 187
LEU A  81
ALA A  85
MET A 124
ILE A 135
 PG4  A 216 (-4.7A)
None
PG4  A 216 ( 4.1A)
None
None
 1.13A 5ljbA-3ppbA:
undetectable		 5ljbA-3ppbA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3ppb PUTATIVE TETR FAMILY
TRANSCRIPTION
REGULATOR
(Shewanella
loihica) 		5 / 12 PHE A 187
LEU A  81
ALA A  85
LEU A  88
ILE A 135
 PG4  A 216 (-4.7A)
None
PG4  A 216 ( 4.1A)
PG4  A 216 (-3.8A)
None
 0.66A 5ljcA-3ppbA:
undetectable		 5ljcA-3ppbA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 3ppb PUTATIVE TETR FAMILY
TRANSCRIPTION
REGULATOR
(Shewanella
loihica) 		4 / 8 ALA A 123
GLY A 129
LEU A 128
ALA A  68
 None
None
PG4  A 216 (-4.6A)
None
 0.83A 6mdqA-3ppbA:
3.7		 6mdqA-3ppbA:
17.62