SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ppi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2
(Mycobacterium
avium) 		4 / 4 ARG A 249
ALA A 194
ALA A 154
GLU A 157
 None
 0.94A 1e7bA-3ppiA:
undetectable		 1e7bA-3ppiA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2
(Mycobacterium
avium) 		4 / 4 ARG A 249
ALA A 194
ALA A 154
GLU A 157
 None
 1.00A 1e7bB-3ppiA:
undetectable		 1e7bB-3ppiA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2
(Mycobacterium
avium) 		4 / 5 ARG A 249
ALA A 194
ALA A 154
GLU A 157
 None
 0.96A 1e7cA-3ppiA:
undetectable		 1e7cA-3ppiA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2
(Mycobacterium
avium) 		4 / 7 ALA A  85
VAL A 125
GLY A  16
ILE A  37
 None
 0.77A 1t7iB-3ppiA:
undetectable		 1t7iB-3ppiA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2
(Mycobacterium
avium) 		4 / 7 ALA A  85
VAL A 125
GLY A  16
ILE A  37
 None
 0.73A 1t7jB-3ppiA:
undetectable		 1t7jB-3ppiA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2
(Mycobacterium
avium) 		5 / 12 ILE A  12
ALA A  76
SER A  10
LEU A 147
ILE A 188
 None
 1.12A 2h77A-3ppiA:
undetectable		 2h77A-3ppiA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2
(Mycobacterium
avium) 		5 / 12 SER A 152
ILE A 153
ALA A 154
TYR A 165
THR A 197
 None
 0.85A 2japA-3ppiA:
29.7		 2japA-3ppiA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2
(Mycobacterium
avium) 		5 / 12 SER A 152
ILE A 153
ALA A 154
TYR A 165
THR A 197
 None
 0.86A 2japB-3ppiA:
29.7		 2japB-3ppiA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2
(Mycobacterium
avium) 		5 / 12 SER A 152
ILE A 153
ALA A 154
TYR A 165
THR A 197
 None
 0.88A 2japC-3ppiA:
29.7		 2japC-3ppiA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2
(Mycobacterium
avium) 		5 / 12 SER A 152
ILE A 153
ALA A 154
TYR A 165
THR A 197
 None
 0.87A 2japD-3ppiA:
29.6		 2japD-3ppiA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2
(Mycobacterium
avium) 		5 / 12 GLY A  15
ALA A  17
ALA A  23
VAL A  63
LEU A 117
 GOL  A 302 ( 3.3A)
None
None
GOL  A 302 (-3.6A)
None
 1.01A 2nyuA-3ppiA:
9.1		 2nyuA-3ppiA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2
(Mycobacterium
avium) 		5 / 12 GLY A  15
ALA A  17
LEU A  40
VAL A  63
LEU A 117
 GOL  A 302 ( 3.3A)
None
GOL  A 302 ( 4.4A)
GOL  A 302 (-3.6A)
None
 0.87A 2nyuA-3ppiA:
9.1		 2nyuA-3ppiA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2
(Mycobacterium
avium) 		6 / 12 GLY A  15
ALA A  17
LEU A  40
VAL A  63
THR A  64
LEU A 117
 GOL  A 302 ( 3.3A)
None
GOL  A 302 ( 4.4A)
GOL  A 302 (-3.6A)
None
None
 0.89A 2nyuB-3ppiA:
8.3		 2nyuB-3ppiA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2
(Mycobacterium
avium) 		4 / 8 ILE A  12
PHE A 230
GLY A  16
GLY A  15
 None
None
None
GOL  A 302 ( 3.3A)
 0.82A 2qx4A-3ppiA:
5.6
2qx4B-3ppiA:
5.4		 2qx4A-3ppiA:
21.77
2qx4B-3ppiA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2
(Mycobacterium
avium) 		4 / 6 ALA A 231
ALA A 235
THR A 239
PHE A   6
 None
 0.54A 2xfhA-3ppiA:
undetectable		 2xfhA-3ppiA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2
(Mycobacterium
avium) 		4 / 8 LEU A 175
ALA A 194
THR A 192
GLY A 121
 None
 0.95A 3ny4A-3ppiA:
undetectable		 3ny4A-3ppiA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2
(Mycobacterium
avium) 		3 / 3 ARG A 127
GLU A  66
ASN A 124
 None
 0.90A 4imaD-3ppiA:
1.7		 4imaD-3ppiA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2
(Mycobacterium
avium) 		3 / 3 ARG A 127
GLU A  66
ASN A 124
 None
 0.87A 4ip7D-3ppiA:
2.7		 4ip7D-3ppiA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2
(Mycobacterium
avium) 		5 / 10 ALA A 231
ALA A 234
ALA A 235
THR A 239
LEU A  33
 None
 1.19A 4j6cB-3ppiA:
undetectable		 4j6cB-3ppiA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2
(Mycobacterium
avium) 		5 / 12 ALA A 231
ALA A 234
ALA A 235
THR A 239
LEU A  33
 None
 1.12A 4j6dA-3ppiA:
undetectable		 4j6dA-3ppiA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2
(Mycobacterium
avium) 		5 / 12 ALA A 231
ALA A 234
ALA A 235
THR A 239
LEU A  33
 None
 1.12A 4j6dB-3ppiA:
undetectable		 4j6dB-3ppiA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2
(Mycobacterium
avium) 		5 / 12 ILE A  12
ALA A  76
SER A  10
LEU A 147
ILE A 188
 None
 1.07A 4lnwA-3ppiA:
undetectable		 4lnwA-3ppiA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2
(Mycobacterium
avium) 		5 / 12 ILE A  12
ALA A  76
SER A  10
LEU A 147
ILE A 188
 None
 1.08A 4lnxA-3ppiA:
undetectable		 4lnxA-3ppiA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2
(Mycobacterium
avium) 		5 / 10 HIS A  89
LEU A 117
SER A  14
VAL A 125
VAL A  69
 None
 1.35A 4yb6A-3ppiA:
undetectable
4yb6D-3ppiA:
undetectable		 4yb6A-3ppiA:
21.66
4yb6D-3ppiA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2
(Mycobacterium
avium) 		5 / 12 ILE A  12
ALA A  11
ALA A  56
ARG A  55
LEU A  79
 None
None
MG  A 300 (-4.3A)
None
None
 1.44A 4zo1X-3ppiA:
undetectable		 4zo1X-3ppiA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2
(Mycobacterium
avium) 		4 / 6 THR A  24
ARG A  27
LEU A  28
ASP A  31
 None
 1.19A 5tdzA-3ppiA:
6.5		 5tdzA-3ppiA:
21.52