SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ppl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 3ppl ASPARTATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 8 GLN A  96
ASP A 237
VAL A 235
GLY A  91
 None
 0.85A 1ekjA-3pplA:
undetectable
1ekjB-3pplA:
undetectable		 1ekjA-3pplA:
20.79
1ekjB-3pplA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 3ppl ASPARTATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 6 GLN A  96
ASP A 237
VAL A 235
GLY A  91
 None
 0.78A 1ekjC-3pplA:
undetectable
1ekjD-3pplA:
undetectable		 1ekjC-3pplA:
20.79
1ekjD-3pplA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 3ppl ASPARTATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 6 ASP A 237
VAL A 235
GLY A  91
GLN A  96
 None
 0.80A 1ekjC-3pplA:
undetectable
1ekjD-3pplA:
undetectable		 1ekjC-3pplA:
20.79
1ekjD-3pplA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 3ppl ASPARTATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 8 GLN A  96
ASP A 237
VAL A 235
GLY A  91
 None
 0.81A 1ekjE-3pplA:
undetectable
1ekjF-3pplA:
undetectable		 1ekjE-3pplA:
20.79
1ekjF-3pplA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3ppl ASPARTATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 8 PRO A 388
ASP A 387
LYS A 391
THR A 193
 None
 1.22A 1p7lC-3pplA:
undetectable		 1p7lC-3pplA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3ppl ASPARTATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 8 PRO A 388
ASP A 387
LYS A 391
THR A 193
 None
 1.22A 1p7lD-3pplA:
undetectable		 1p7lD-3pplA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 3ppl ASPARTATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 ILE A 373
LEU A  37
GLY A 411
ALA A 413
LEU A 354
 None
 1.05A 1r9oA-3pplA:
undetectable		 1r9oA-3pplA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 3ppl ASPARTATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 11 ALA A 336
LEU A 417
THR A 360
ALA A 420
VAL A 416
 None
 1.10A 1rv7A-3pplA:
undetectable
1rv7B-3pplA:
undetectable		 1rv7A-3pplA:
11.40
1rv7B-3pplA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ppl ASPARTATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 TYR A 302
PHE A 303
ALA A 306
ALA A 265
ALA A 263
 None
 1.10A 2x2nA-3pplA:
undetectable		 2x2nA-3pplA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3ppl ASPARTATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 10 ASN A 295
VAL A 267
TYR A 302
GLY A 266
LEU A  56
 None
 1.47A 3lp1A-3pplA:
undetectable		 3lp1A-3pplA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 3ppl ASPARTATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 SER A 353
PRO A 140
GLY A 141
LEU A  37
ASP A  36
 None
 1.48A 3r24A-3pplA:
2.5		 3r24A-3pplA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3ppl ASPARTATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 7 HIS A 145
VAL A 218
ILE A 112
ILE A 148
 PLP  A 500 ( 4.9A)
None
None
None
 0.77A 4lv9A-3pplA:
2.1		 4lv9A-3pplA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3ppl ASPARTATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 7 HIS A 145
VAL A 218
ILE A 112
ILE A 148
 PLP  A 500 ( 4.9A)
None
None
None
 0.75A 4lv9B-3pplA:
2.7		 4lv9B-3pplA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 3ppl ASPARTATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 7 ARG A 250
VAL A 217
LEU A 205
SER A 206
 None
 0.86A 4zphA-3pplA:
undetectable
4zphB-3pplA:
undetectable		 4zphA-3pplA:
21.13
4zphB-3pplA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 3ppl ASPARTATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		3 / 3 ASP A 143
ARG A 144
TYR A 142
 UNL  A 600 ( 2.8A)
UNL  A 600 ( 3.5A)
PLP  A 500 (-3.8A)
 1.05A 5a7mA-3pplA:
4.8		 5a7mA-3pplA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 3ppl ASPARTATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		3 / 3 ASP A 143
ARG A 144
TYR A 142
 UNL  A 600 ( 2.8A)
UNL  A 600 ( 3.5A)
PLP  A 500 (-3.8A)
 1.02A 5a7mB-3pplA:
4.8		 5a7mB-3pplA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3ppl ASPARTATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 5 LEU A  89
PHE A 269
ILE A  85
ILE A  82
 None
 1.00A 5dzk4-3pplA:
undetectable
5dzkg-3pplA:
undetectable
5dzkm-3pplA:
undetectable
5dzkn-3pplA:
undetectable		 5dzk4-3pplA:
3.64
5dzkg-3pplA:
19.91
5dzkm-3pplA:
19.58
5dzkn-3pplA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 3ppl ASPARTATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 ASP A  20
PHE A   9
LEU A 335
GLU A 337
VAL A 340
 None
 1.04A 5hw4A-3pplA:
2.1		 5hw4A-3pplA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 3ppl ASPARTATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 11 ASP A  20
PHE A   9
LEU A 335
GLU A 337
VAL A 340
 None
 1.00A 5hw4B-3pplA:
undetectable		 5hw4B-3pplA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 3ppl ASPARTATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 ASP A  20
PHE A   9
LEU A 335
GLU A 337
VAL A 340
 None
 1.03A 5hw4C-3pplA:
undetectable		 5hw4C-3pplA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3ppl ASPARTATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 LYS A  24
ASP A 410
GLY A 411
LEU A 367
ALA A 419
 None
 1.32A 5kbwA-3pplA:
undetectable		 5kbwA-3pplA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3ppl ASPARTATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 8 PRO A 388
ASP A 387
LYS A 391
THR A 193
 None
 1.17A 5t8sB-3pplA:
undetectable		 5t8sB-3pplA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 3ppl ASPARTATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 LEU A 418
ALA A 419
GLU A 422
ILE A 373
LEU A 393
 None
 1.05A 5toaA-3pplA:
undetectable		 5toaA-3pplA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 3ppl ASPARTATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 LEU A 354
GLY A 411
ASP A 410
GLU A  27
THR A 414
 None
 1.23A 5x6yC-3pplA:
undetectable		 5x6yC-3pplA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3ppl ASPARTATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		3 / 3 LYS A 391
ASN A 392
SER A 353
 None
 1.10A 5yw0A-3pplA:
undetectable		 5yw0A-3pplA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 3ppl ASPARTATE
AMINOTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 9 VAL A 416
LEU A  37
ALA A 408
VAL A 407
ASP A 410
 None
 1.29A 6c2mB-3pplA:
undetectable		 6c2mB-3pplA:
12.21