SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ppz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 GLY A 558
VAL A 565
ALA A 576
VAL A 609
ASN A 681
LEU A 683
ASP A 694
 STU  A   1 (-3.2A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
STU  A   1 (-4.6A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.76A 1fmoE-3ppzA:
26.2		 1fmoE-3ppzA:
27.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 ALA A 576
GLU A 596
MET A 600
THR A 625
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.43A 1iepA-3ppzA:
28.9		 1iepA-3ppzA:
35.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		4 / 6 LYS A 578
VAL A 609
ILE A 623
ARG A 675
 STU  A   1 (-3.5A)
None
None
SEP  A 710 ( 3.6A)
 1.13A 1iepA-3ppzA:
28.9		 1iepA-3ppzA:
35.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 ALA A 576
LYS A 578
GLU A 596
THR A 625
GLY A 631
LEU A 683
ASP A 694
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.76A 1m17A-3ppzA:
31.2		 1m17A-3ppzA:
27.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 ALA A 576
GLU A 596
MET A 600
VAL A 609
THR A 625
GLY A 631
 STU  A   1 (-3.3A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
 0.57A 1opjB-3ppzA:
28.4		 1opjB-3ppzA:
35.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 VAL A 565
ALA A 576
MET A 600
VAL A 609
THR A 625
GLY A 631
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
 0.77A 1opjB-3ppzA:
28.4		 1opjB-3ppzA:
35.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		5 / 12 ALA A 576
GLU A 596
THR A 625
LEU A 665
HIS A 674
 STU  A   1 (-3.3A)
None
STU  A   1 (-4.1A)
None
None
 0.64A 1uwhA-3ppzA:
29.2		 1uwhA-3ppzA:
39.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 ALA A 576
LYS A 578
GLU A 596
THR A 625
LEU A 665
HIS A 674
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.1A)
None
None
 0.60A 1uwhB-3ppzA:
29.1		 1uwhB-3ppzA:
39.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 VAL A 565
ALA A 576
GLU A 596
THR A 625
LEU A 665
HIS A 674
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
STU  A   1 (-4.1A)
None
None
 0.70A 1uwjA-3ppzA:
8.0		 1uwjA-3ppzA:
39.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 ILE A 557
VAL A 565
ALA A 576
GLU A 596
THR A 625
LEU A 665
HIS A 674
 STU  A   1 (-4.1A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
STU  A   1 (-4.1A)
None
None
 0.90A 1uwjB-3ppzA:
8.0		 1uwjB-3ppzA:
39.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 ALA A 576
THR A 625
GLY A 631
LEU A 683
ASP A 694
PHE A 695
 STU  A   1 (-3.3A)
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
None
 0.86A 1xkkA-3ppzA:
28.4		 1xkkA-3ppzA:
32.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 ILE A 557
VAL A 565
LYS A 578
VAL A 609
ASN A 681
LEU A 683
ASP A 694
 STU  A   1 (-4.1A)
STU  A   1 (-4.9A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.6A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.89A 2eufB-3ppzA:
27.8		 2eufB-3ppzA:
26.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 11 GLY A 558
VAL A 565
ALA A 576
TYR A 627
SER A 632
LEU A 683
 STU  A   1 (-3.2A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.4A)
STU  A   1 ( 4.3A)
STU  A   1 (-4.3A)
 0.56A 2evaA-3ppzA:
30.3		 2evaA-3ppzA:
32.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 GLY A 558
VAL A 565
ALA A 576
TYR A 627
LYS A 678
ASN A 681
ASP A 694
 STU  A   1 (-3.2A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.4A)
None
STU  A   1 (-4.6A)
STU  A   1 (-3.5A)
 0.88A 2fumB-3ppzA:
27.1		 2fumB-3ppzA:
29.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 ALA A 576
LYS A 578
MET A 600
VAL A 609
ILE A 623
THR A 625
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.58A 2gqgA-3ppzA:
31.6		 2gqgA-3ppzA:
35.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		9 / 12 VAL A 565
ALA A 576
LYS A 578
MET A 600
VAL A 609
ILE A 623
THR A 625
GLY A 631
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.54A 2gqgB-3ppzA:
32.4		 2gqgB-3ppzA:
35.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 ALA A 576
GLU A 596
MET A 600
THR A 625
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.49A 2hyyA-3ppzA:
28.9		 2hyyA-3ppzA:
33.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 VAL A 565
ALA A 576
MET A 600
THR A 625
GLY A 631
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.75A 2hyyA-3ppzA:
28.9		 2hyyA-3ppzA:
33.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		4 / 6 LYS A 578
VAL A 609
ILE A 623
ARG A 675
 STU  A   1 (-3.5A)
None
None
SEP  A 710 ( 3.6A)
 0.91A 2hyyA-3ppzA:
28.9		 2hyyA-3ppzA:
33.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 ALA A 576
GLU A 596
MET A 600
THR A 625
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.41A 2hyyB-3ppzA:
29.2		 2hyyB-3ppzA:
33.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 VAL A 565
ALA A 576
MET A 600
THR A 625
GLY A 631
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.72A 2hyyB-3ppzA:
29.2		 2hyyB-3ppzA:
33.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 ALA A 576
GLU A 596
VAL A 609
THR A 625
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.51A 2hyyC-3ppzA:
29.2		 2hyyC-3ppzA:
33.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 ALA A 576
GLU A 596
MET A 600
ILE A 623
THR A 625
LEU A 683
 STU  A   1 (-3.3A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.3A)
 0.68A 2hyyD-3ppzA:
29.0		 2hyyD-3ppzA:
33.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 VAL A 565
ALA A 576
MET A 600
ILE A 623
THR A 625
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.3A)
 0.79A 2hyyD-3ppzA:
29.0		 2hyyD-3ppzA:
33.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 GLY A 558
VAL A 565
ALA A 576
LYS A 578
MET A 600
THR A 625
GLY A 631
ASP A 694
 STU  A   1 (-3.2A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-3.5A)
 0.83A 2ityA-3ppzA:
29.7		 2ityA-3ppzA:
26.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		10 / 12 VAL A 565
ALA A 576
LYS A 578
GLU A 596
MET A 600
ILE A 623
THR A 625
TYR A 627
GLY A 631
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.77A 2oiqA-3ppzA:
29.4		 2oiqA-3ppzA:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 ALA A 576
GLU A 596
MET A 600
VAL A 609
ILE A 623
THR A 625
TYR A 627
LEU A 683
 STU  A   1 (-3.3A)
None
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-4.3A)
 0.93A 2pl0A-3ppzA:
28.8		 2pl0A-3ppzA:
32.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		9 / 12 VAL A 565
ALA A 576
LYS A 578
GLU A 596
MET A 600
VAL A 609
ILE A 623
THR A 625
TYR A 627
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
 0.77A 2pl0A-3ppzA:
28.8		 2pl0A-3ppzA:
32.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 GLY A 558
VAL A 565
ALA A 576
TYR A 627
GLY A 631
ASP A 694
 STU  A   1 (-3.2A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-3.5A)
 0.70A 2wgjA-3ppzA:
28.9		 2wgjA-3ppzA:
31.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		9 / 12 ILE A 557
ALA A 576
LYS A 578
GLU A 596
MET A 600
ILE A 623
THR A 625
TYR A 627
LEU A 683
 STU  A   1 (-4.1A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-4.3A)
 0.82A 2y6oA-3ppzA:
29.4		 2y6oA-3ppzA:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		9 / 12 ILE A 557
ALA A 576
LYS A 578
MET A 600
ILE A 623
THR A 625
TYR A 627
GLY A 631
LEU A 683
 STU  A   1 (-4.1A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.67A 2y6oA-3ppzA:
29.4		 2y6oA-3ppzA:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 ILE A 557
VAL A 565
ALA A 576
GLY A 631
LEU A 683
ASP A 694
 STU  A   1 (-4.1A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.69A 2y7jA-3ppzA:
29.0		 2y7jA-3ppzA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 10 ILE A 557
VAL A 565
ALA A 576
GLY A 631
LEU A 683
ASP A 694
 STU  A   1 (-4.1A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.70A 2y7jB-3ppzA:
29.3		 2y7jB-3ppzA:
28.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 ALA A 576
LYS A 578
GLU A 596
MET A 600
VAL A 609
ILE A 623
THR A 625
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
None
STU  A   1 (-4.1A)
 0.80A 2zvaA-3ppzA:
32.5		 2zvaA-3ppzA:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 ALA A 576
LYS A 578
MET A 600
VAL A 609
ILE A 623
THR A 625
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.60A 2zvaA-3ppzA:
32.5		 2zvaA-3ppzA:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 VAL A 565
ALA A 576
THR A 625
GLY A 631
LEU A 683
ASP A 694
PHE A 695
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
None
 0.89A 3bbtB-3ppzA:
28.0		 3bbtB-3ppzA:
30.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 GLY A 558
ALA A 576
LYS A 578
VAL A 609
GLY A 631
LEU A 683
CYH A 693
 STU  A   1 (-3.2A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.82A 3c7qA-3ppzA:
26.9		 3c7qA-3ppzA:
31.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		5 / 10 VAL A 565
LYS A 578
VAL A 609
ILE A 623
VAL A 692
 STU  A   1 (-4.9A)
STU  A   1 (-3.5A)
None
None
None
 0.83A 3cs9A-3ppzA:
28.7		 3cs9A-3ppzA:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 ALA A 576
MET A 600
THR A 625
GLY A 631
HIS A 674
LEU A 683
 STU  A   1 (-3.3A)
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
None
STU  A   1 (-4.3A)
 0.41A 3cs9A-3ppzA:
28.7		 3cs9A-3ppzA:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 GLU A 596
MET A 600
THR A 625
GLY A 631
HIS A 674
LEU A 683
 None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
None
STU  A   1 (-4.3A)
 0.52A 3cs9A-3ppzA:
28.7		 3cs9A-3ppzA:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		5 / 12 ALA A 576
MET A 600
THR A 625
GLY A 631
HIS A 674
 STU  A   1 (-3.3A)
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
None
 0.37A 3cs9B-3ppzA:
29.0		 3cs9B-3ppzA:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		5 / 12 GLU A 596
MET A 600
THR A 625
GLY A 631
HIS A 674
 None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
None
 0.55A 3cs9B-3ppzA:
29.0		 3cs9B-3ppzA:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		5 / 9 VAL A 565
LYS A 578
VAL A 609
ILE A 623
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.3A)
 0.88A 3cs9B-3ppzA:
29.0		 3cs9B-3ppzA:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		5 / 12 ALA A 576
GLU A 596
MET A 600
THR A 625
HIS A 674
 STU  A   1 (-3.3A)
None
None
STU  A   1 (-4.1A)
None
 0.59A 3cs9C-3ppzA:
28.7		 3cs9C-3ppzA:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		5 / 12 ALA A 576
MET A 600
THR A 625
GLY A 631
HIS A 674
 STU  A   1 (-3.3A)
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
None
 0.34A 3cs9D-3ppzA:
27.7		 3cs9D-3ppzA:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		5 / 12 GLU A 596
MET A 600
THR A 625
GLY A 631
HIS A 674
 None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
None
 0.64A 3cs9D-3ppzA:
27.7		 3cs9D-3ppzA:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 GLY A 558
GLY A 560
GLY A 563
VAL A 565
ALA A 576
TYR A 627
SER A 632
LEU A 683
 STU  A   1 (-3.2A)
None
None
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.4A)
STU  A   1 ( 4.3A)
STU  A   1 (-4.3A)
 0.77A 3fupA-3ppzA:
29.9		 3fupA-3ppzA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 GLY A 558
GLY A 560
ALA A 576
LYS A 578
VAL A 609
TYR A 627
LEU A 628
LEU A 683
 STU  A   1 (-3.2A)
None
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.4A)
STU  A   1 (-4.5A)
STU  A   1 (-4.3A)
 0.54A 3fupB-3ppzA:
30.2		 3fupB-3ppzA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 GLY A 558
GLY A 560
VAL A 565
ALA A 576
LYS A 578
TYR A 627
LEU A 628
LEU A 683
 STU  A   1 (-3.2A)
None
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
STU  A   1 (-4.4A)
STU  A   1 (-4.5A)
STU  A   1 (-4.3A)
 0.61A 3fupB-3ppzA:
30.2		 3fupB-3ppzA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 11 ALA A 576
VAL A 609
THR A 625
TYR A 627
GLY A 631
LEU A 683
CYH A 693
 STU  A   1 (-3.3A)
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.44A 3g0eA-3ppzA:
26.3		 3g0eA-3ppzA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 11 VAL A 565
ALA A 576
VAL A 609
TYR A 627
GLY A 631
LEU A 683
CYH A 693
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.73A 3g0eA-3ppzA:
26.3		 3g0eA-3ppzA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 11 VAL A 565
ALA A 576
THR A 625
TYR A 627
GLY A 631
LEU A 683
CYH A 693
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.77A 3g0fA-3ppzA:
26.9		 3g0fA-3ppzA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 10 VAL A 565
ALA A 576
THR A 625
TYR A 627
GLY A 631
LEU A 683
CYH A 693
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.69A 3g0fB-3ppzA:
27.5		 3g0fB-3ppzA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 ALA A 576
MET A 600
VAL A 609
ILE A 623
THR A 625
TYR A 627
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.39A 3g5dA-3ppzA:
30.9		 3g5dA-3ppzA:
32.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 VAL A 565
ALA A 576
VAL A 609
ILE A 623
THR A 625
TYR A 627
GLY A 631
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.50A 3g5dA-3ppzA:
30.9		 3g5dA-3ppzA:
32.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		9 / 12 VAL A 565
ALA A 576
LYS A 578
MET A 600
VAL A 609
THR A 625
TYR A 627
GLY A 631
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.52A 3g5dB-3ppzA:
30.8		 3g5dB-3ppzA:
32.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 ALA A 576
GLU A 596
MET A 600
VAL A 609
THR A 625
LEU A 683
 STU  A   1 (-3.3A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.3A)
 0.49A 3gvuA-3ppzA:
29.2		 3gvuA-3ppzA:
39.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 VAL A 565
ALA A 576
MET A 600
VAL A 609
THR A 625
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.3A)
 0.60A 3gvuA-3ppzA:
29.2		 3gvuA-3ppzA:
39.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		5 / 12 ALA A 576
GLU A 596
MET A 600
HIS A 674
LEU A 683
 STU  A   1 (-3.3A)
None
None
None
STU  A   1 (-4.3A)
 0.55A 3ik3A-3ppzA:
28.7		 3ik3A-3ppzA:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		5 / 12 ALA A 576
MET A 600
VAL A 609
HIS A 674
LEU A 683
 STU  A   1 (-3.3A)
None
None
None
STU  A   1 (-4.3A)
 0.68A 3ik3A-3ppzA:
28.7		 3ik3A-3ppzA:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		5 / 12 ALA A 576
GLU A 596
MET A 600
HIS A 674
LEU A 683
 STU  A   1 (-3.3A)
None
None
None
STU  A   1 (-4.3A)
 0.53A 3ik3B-3ppzA:
28.4		 3ik3B-3ppzA:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		5 / 12 ALA A 576
MET A 600
VAL A 609
HIS A 674
LEU A 683
 STU  A   1 (-3.3A)
None
None
None
STU  A   1 (-4.3A)
 0.71A 3ik3B-3ppzA:
28.4		 3ik3B-3ppzA:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		9 / 12 ALA A 576
GLU A 596
MET A 600
VAL A 609
ILE A 623
THR A 625
TYR A 627
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
None
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.70A 3k54A-3ppzA:
29.5		 3k54A-3ppzA:
30.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		9 / 12 ALA A 576
LYS A 578
GLU A 596
MET A 600
VAL A 609
ILE A 623
THR A 625
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.78A 3k54A-3ppzA:
29.5		 3k54A-3ppzA:
30.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 ALA A 576
GLU A 596
MET A 600
THR A 625
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.47A 3k5vA-3ppzA:
21.0		 3k5vA-3ppzA:
35.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 VAL A 565
ALA A 576
MET A 600
THR A 625
GLY A 631
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.71A 3k5vA-3ppzA:
21.0		 3k5vA-3ppzA:
35.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 ALA A 576
GLU A 596
MET A 600
THR A 625
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.44A 3k5vB-3ppzA:
28.5		 3k5vB-3ppzA:
35.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 VAL A 565
ALA A 576
MET A 600
THR A 625
GLY A 631
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.72A 3k5vB-3ppzA:
28.5		 3k5vB-3ppzA:
35.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 GLY A 558
GLY A 560
VAL A 565
ALA A 576
TYR A 627
SER A 632
LEU A 683
 STU  A   1 (-3.2A)
None
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.4A)
STU  A   1 ( 4.3A)
STU  A   1 (-4.3A)
 0.57A 3lxnA-3ppzA:
29.5		 3lxnA-3ppzA:
32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		4 / 6 LYS A 578
VAL A 609
ILE A 623
ARG A 675
 STU  A   1 (-3.5A)
None
None
SEP  A 710 ( 3.6A)
 0.71A 3ms9A-3ppzA:
28.5		 3ms9A-3ppzA:
35.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 ALA A 576
GLU A 596
MET A 600
THR A 625
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.45A 3ms9B-3ppzA:
28.6		 3ms9B-3ppzA:
35.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		4 / 7 LYS A 578
VAL A 609
ILE A 623
ARG A 675
 STU  A   1 (-3.5A)
None
None
SEP  A 710 ( 3.6A)
 0.73A 3ms9B-3ppzA:
28.6		 3ms9B-3ppzA:
35.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		4 / 6 LYS A 578
VAL A 609
ILE A 623
ARG A 675
 STU  A   1 (-3.5A)
None
None
SEP  A 710 ( 3.6A)
 0.72A 3mssA-3ppzA:
28.6		 3mssA-3ppzA:
35.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		4 / 6 LYS A 578
VAL A 609
ILE A 623
ARG A 675
 STU  A   1 (-3.5A)
None
None
SEP  A 710 ( 3.6A)
 0.75A 3mssC-3ppzA:
28.6		 3mssC-3ppzA:
35.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 ALA A 576
GLU A 596
MET A 600
THR A 625
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.48A 3mssD-3ppzA:
28.7		 3mssD-3ppzA:
35.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		4 / 6 VAL A 565
LYS A 578
VAL A 609
ILE A 623
 STU  A   1 (-4.9A)
STU  A   1 (-3.5A)
None
None
 0.62A 3mssD-3ppzA:
28.7		 3mssD-3ppzA:
35.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		9 / 12 VAL A 565
ALA A 576
LYS A 578
MET A 600
VAL A 609
THR A 625
TYR A 627
GLY A 631
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.55A 3octA-3ppzA:
29.6		 3octA-3ppzA:
32.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 VAL A 565
ALA A 576
MET A 600
VAL A 609
THR A 625
TYR A 627
GLY A 631
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.53A 3oezA-3ppzA:
29.1		 3oezA-3ppzA:
32.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		9 / 12 VAL A 565
ALA A 576
LYS A 578
GLU A 596
MET A 600
ILE A 623
THR A 625
TYR A 627
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-4.3A)
 0.56A 3oezB-3ppzA:
29.5		 3oezB-3ppzA:
32.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		5 / 12 VAL A 565
ALA A 576
LYS A 578
THR A 625
PHE A 695
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
STU  A   1 (-4.1A)
None
 0.77A 3og7A-3ppzA:
29.7		 3og7A-3ppzA:
38.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 GLY A 558
VAL A 565
ALA A 576
LYS A 578
THR A 625
GLY A 631
 STU  A   1 (-3.2A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
 0.90A 3ohtB-3ppzA:
17.1		 3ohtB-3ppzA:
26.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 ALA A 576
GLU A 596
MET A 600
VAL A 609
THR A 625
GLY A 631
HIS A 674
 STU  A   1 (-3.3A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
None
 0.57A 3oxzA-3ppzA:
28.8		 3oxzA-3ppzA:
33.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		5 / 9 LYS A 578
ILE A 623
ARG A 675
LEU A 683
VAL A 692
 STU  A   1 (-3.5A)
None
SEP  A 710 ( 3.6A)
STU  A   1 (-4.3A)
None
 0.76A 3oxzA-3ppzA:
28.8		 3oxzA-3ppzA:
33.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		4 / 6 LYS A 578
VAL A 609
ILE A 623
ARG A 675
 STU  A   1 (-3.5A)
None
None
SEP  A 710 ( 3.6A)
 0.87A 3pyyA-3ppzA:
28.6		 3pyyA-3ppzA:
36.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 ALA A 576
GLU A 596
MET A 600
VAL A 609
THR A 625
LEU A 683
 STU  A   1 (-3.3A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.3A)
 0.51A 3pyyB-3ppzA:
28.5		 3pyyB-3ppzA:
36.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 VAL A 565
ALA A 576
MET A 600
VAL A 609
THR A 625
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.3A)
 0.66A 3pyyB-3ppzA:
28.5		 3pyyB-3ppzA:
36.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		9 / 12 VAL A 565
ALA A 576
LYS A 578
MET A 600
VAL A 609
THR A 625
TYR A 627
GLY A 631
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.48A 3qlgA-3ppzA:
29.8		 3qlgA-3ppzA:
32.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		9 / 12 VAL A 565
ALA A 576
MET A 600
VAL A 609
THR A 625
TYR A 627
GLY A 631
LEU A 683
ASP A 694
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.58A 3qlgB-3ppzA:
30.8		 3qlgB-3ppzA:
32.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		5 / 12 PHE A 695
ASP A 733
GLY A 696
SER A 698
ALA A 712
 None
None
None
None
SEP  A 710 ( 4.2A)
 0.89A 3sufB-3ppzA:
undetectable		 3sufB-3ppzA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		5 / 11 PHE A 695
ASP A 733
GLY A 696
SER A 698
ALA A 712
 None
None
None
None
SEP  A 710 ( 4.2A)
 0.88A 3sufC-3ppzA:
undetectable		 3sufC-3ppzA:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 VAL A 565
ALA A 576
MET A 600
VAL A 609
THR A 625
TYR A 627
GLY A 631
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.48A 3sxrA-3ppzA:
32.0		 3sxrA-3ppzA:
34.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 VAL A 565
ALA A 576
VAL A 609
ILE A 623
THR A 625
TYR A 627
GLY A 631
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.47A 3sxrA-3ppzA:
32.0		 3sxrA-3ppzA:
34.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 VAL A 565
ALA A 576
MET A 600
VAL A 609
THR A 625
TYR A 627
GLY A 631
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.47A 3sxrB-3ppzA:
31.5		 3sxrB-3ppzA:
34.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 ALA A 576
LYS A 578
GLU A 596
VAL A 609
ILE A 623
THR A 625
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.60A 3ue4A-3ppzA:
32.0		 3ue4A-3ppzA:
33.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		9 / 12 VAL A 565
ALA A 576
GLU A 596
MET A 600
VAL A 609
ILE A 623
THR A 625
GLY A 631
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.65A 3ue4B-3ppzA:
31.5		 3ue4B-3ppzA:
33.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 ILE A 557
GLY A 560
GLY A 563
ALA A 576
LYS A 578
VAL A 609
LEU A 683
ASP A 694
 STU  A   1 (-4.1A)
None
None
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.99A 3v5wA-3ppzA:
8.2		 3v5wA-3ppzA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 ILE A 557
GLY A 560
GLY A 563
VAL A 565
ALA A 576
LYS A 578
LEU A 580
 STU  A   1 (-4.1A)
None
None
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
 0.71A 3v5wA-3ppzA:
8.2		 3v5wA-3ppzA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 ILE A 557
GLY A 560
GLY A 563
VAL A 565
ALA A 576
LYS A 578
LEU A 683
ASP A 694
 STU  A   1 (-4.1A)
None
None
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.94A 3v5wA-3ppzA:
8.2		 3v5wA-3ppzA:
18.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		4 / 5 ILE A 599
VAL A 609
LEU A 683
ASP A 694
 None
None
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.90A 3wzdA-3ppzA:
27.9		 3wzdA-3ppzA:
32.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		4 / 5 LYS A 578
VAL A 609
LEU A 683
ASP A 694
 STU  A   1 (-3.5A)
None
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.97A 3wzdA-3ppzA:
27.9		 3wzdA-3ppzA:
32.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 ALA A 576
LYS A 578
GLU A 596
THR A 625
LEU A 665
HIS A 674
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.1A)
None
None
STU  A   1 (-4.3A)
 0.59A 3zosA-3ppzA:
27.3		 3zosA-3ppzA:
31.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 ALA A 576
LYS A 578
GLU A 596
THR A 625
LEU A 665
HIS A 674
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.1A)
None
None
STU  A   1 (-4.3A)
 0.61A 3zosB-3ppzA:
27.4		 3zosB-3ppzA:
31.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 ALA A 576
GLU A 596
ILE A 599
MET A 600
THR A 625
TYR A 627
LEU A 683
 STU  A   1 (-3.3A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-4.3A)
 0.93A 4bkjA-3ppzA:
27.5		 4bkjA-3ppzA:
31.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 ALA A 576
GLU A 596
ILE A 599
MET A 600
THR A 625
LEU A 683
 STU  A   1 (-3.3A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.3A)
 0.68A 4bkjB-3ppzA:
27.6		 4bkjB-3ppzA:
31.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		4 / 5 LYS A 578
LEU A 603
TYR A 627
ARG A 675
 STU  A   1 (-3.5A)
None
STU  A   1 (-4.4A)
SEP  A 710 ( 3.6A)
 1.02A 4bkjB-3ppzA:
27.6		 4bkjB-3ppzA:
31.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 ALA A 576
LYS A 578
GLU A 596
ILE A 623
THR A 625
HIS A 674
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.1A)
None
STU  A   1 (-4.3A)
 0.61A 4c8bA-3ppzA:
28.9		 4c8bA-3ppzA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 ALA A 576
LYS A 578
GLU A 596
ILE A 608
THR A 625
HIS A 674
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.1A)
None
STU  A   1 (-4.3A)
 0.54A 4c8bB-3ppzA:
28.3		 4c8bB-3ppzA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 11 GLY A 558
VAL A 565
ALA A 576
TYR A 627
GLY A 631
SER A 632
LEU A 683
 STU  A   1 (-3.2A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 ( 4.3A)
STU  A   1 (-4.3A)
 0.61A 4ckiA-3ppzA:
32.1		 4ckiA-3ppzA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 10 GLY A 558
GLY A 560
VAL A 565
ALA A 576
TYR A 627
SER A 632
LEU A 683
 STU  A   1 (-3.2A)
None
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.4A)
STU  A   1 ( 4.3A)
STU  A   1 (-4.3A)
 0.71A 4ckjA-3ppzA:
32.4		 4ckjA-3ppzA:
32.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 ALA A 576
GLU A 596
ILE A 599
MET A 600
VAL A 609
THR A 625
TYR A 627
LEU A 683
 STU  A   1 (-3.3A)
None
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-4.3A)
 0.62A 4csvA-3ppzA:
29.5		 4csvA-3ppzA:
34.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 VAL A 565
ALA A 576
ILE A 599
MET A 600
VAL A 609
THR A 625
TYR A 627
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-4.3A)
 0.61A 4csvA-3ppzA:
29.5		 4csvA-3ppzA:
34.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 VAL A 565
ALA A 576
ASP A 676
LYS A 678
ASN A 681
LEU A 683
ASP A 694
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
None
STU  A   1 (-4.6A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.75A 4i41A-3ppzA:
25.4		 4i41A-3ppzA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 10 ILE A 557
ALA A 576
VAL A 609
LEU A 628
GLY A 631
LEU A 683
ASP A 694
 STU  A   1 (-4.1A)
STU  A   1 (-3.3A)
None
STU  A   1 (-4.5A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.70A 4ks8A-3ppzA:
29.3		 4ks8A-3ppzA:
29.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 ALA A 576
LYS A 578
GLU A 596
MET A 600
VAL A 609
ILE A 623
THR A 625
ASP A 694
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.5A)
 0.94A 4mxoA-3ppzA:
31.1		 4mxoA-3ppzA:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		10 / 12 VAL A 565
ALA A 576
LYS A 578
MET A 600
VAL A 609
ILE A 623
THR A 625
TYR A 627
GLY A 631
ASP A 694
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-3.5A)
 0.75A 4mxoA-3ppzA:
31.1		 4mxoA-3ppzA:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		10 / 12 VAL A 565
ALA A 576
LYS A 578
VAL A 609
ILE A 623
THR A 625
TYR A 627
GLY A 631
LEU A 683
ASP A 694
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.77A 4mxoB-3ppzA:
30.7		 4mxoB-3ppzA:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 ALA A 576
LYS A 578
GLU A 596
ILE A 623
THR A 625
TYR A 627
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-4.3A)
 0.87A 4mxxA-3ppzA:
30.9		 4mxxA-3ppzA:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 ALA A 576
LYS A 578
GLU A 596
MET A 600
VAL A 609
THR A 625
TYR A 627
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-4.3A)
 0.78A 4mxxA-3ppzA:
30.9		 4mxxA-3ppzA:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 ALA A 576
LYS A 578
ILE A 623
THR A 625
TYR A 627
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.61A 4mxxA-3ppzA:
30.9		 4mxxA-3ppzA:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 ALA A 576
LYS A 578
MET A 600
VAL A 609
THR A 625
TYR A 627
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.76A 4mxxA-3ppzA:
30.9		 4mxxA-3ppzA:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 VAL A 565
ALA A 576
VAL A 609
THR A 625
TYR A 627
GLY A 631
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.40A 4mxxB-3ppzA:
29.2		 4mxxB-3ppzA:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 VAL A 565
ALA A 576
LYS A 578
GLU A 596
VAL A 609
ILE A 623
TYR A 627
ASP A 694
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
STU  A   1 (-4.4A)
STU  A   1 (-3.5A)
 0.89A 4mxyA-3ppzA:
31.4		 4mxyA-3ppzA:
32.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		9 / 12 VAL A 565
ALA A 576
LYS A 578
VAL A 609
ILE A 623
TYR A 627
GLY A 631
LEU A 683
ASP A 694
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.53A 4mxyA-3ppzA:
31.4		 4mxyA-3ppzA:
32.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 VAL A 565
ALA A 576
LYS A 578
VAL A 609
TYR A 627
GLY A 631
LEU A 683
ASP A 694
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.66A 4mxyB-3ppzA:
31.1		 4mxyB-3ppzA:
32.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 VAL A 565
ALA A 576
LYS A 578
GLU A 596
VAL A 609
ILE A 623
TYR A 627
ASP A 694
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
STU  A   1 (-4.4A)
STU  A   1 (-3.5A)
 0.89A 4mxzA-3ppzA:
31.4		 4mxzA-3ppzA:
32.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		9 / 12 VAL A 565
ALA A 576
LYS A 578
VAL A 609
ILE A 623
TYR A 627
GLY A 631
LEU A 683
ASP A 694
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.53A 4mxzA-3ppzA:
31.4		 4mxzA-3ppzA:
32.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 VAL A 565
ALA A 576
LYS A 578
VAL A 609
TYR A 627
GLY A 631
LEU A 683
ASP A 694
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.66A 4mxzB-3ppzA:
31.1		 4mxzB-3ppzA:
32.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 11 GLY A 558
PHE A 562
VAL A 565
ALA A 576
ASN A 681
LEU A 683
ASP A 694
 STU  A   1 (-3.2A)
STU  A   1 ( 4.7A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.6A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.89A 4o0sA-3ppzA:
28.7		 4o0sA-3ppzA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 8 ILE A 557
VAL A 565
ALA A 576
ASN A 681
LEU A 683
ASP A 694
 STU  A   1 (-4.1A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.6A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.71A 4ogrA-3ppzA:
27.6		 4ogrA-3ppzA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 9 ILE A 557
VAL A 565
ALA A 576
ASN A 681
LEU A 683
ASP A 694
 STU  A   1 (-4.1A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.6A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.76A 4ogrI-3ppzA:
27.4		 4ogrI-3ppzA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 GLY A 558
GLY A 560
GLY A 563
VAL A 565
ALA A 576
LYS A 578
LEU A 683
 STU  A   1 (-3.2A)
None
None
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
STU  A   1 (-4.3A)
 0.56A 4otiA-3ppzA:
21.1		 4otiA-3ppzA:
26.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 LYS A 578
VAL A 609
THR A 625
TYR A 627
GLY A 631
LEU A 683
ASP A 694
 STU  A   1 (-3.5A)
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.81A 4otwA-3ppzA:
27.4		 4otwA-3ppzA:
31.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 VAL A 565
VAL A 609
THR A 625
TYR A 627
GLY A 631
LEU A 683
ASP A 694
 STU  A   1 (-4.9A)
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.61A 4otwA-3ppzA:
27.4		 4otwA-3ppzA:
31.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		4 / 6 LYS A 578
LEU A 580
THR A 625
LEU A 621
 STU  A   1 (-3.5A)
None
STU  A   1 (-4.1A)
None
 0.90A 4pwjA-3ppzA:
undetectable		 4pwjA-3ppzA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 ALA A 576
GLU A 596
ILE A 623
TYR A 627
LEU A 683
ASP A 694
 STU  A   1 (-3.3A)
None
None
STU  A   1 (-4.4A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.79A 4qmnA-3ppzA:
30.7		 4qmnA-3ppzA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 11 ALA A 576
LYS A 578
GLU A 596
ILE A 623
TYR A 627
LEU A 628
LEU A 683
ASP A 694
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.4A)
STU  A   1 (-4.5A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.75A 4qmsA-3ppzA:
31.0		 4qmsA-3ppzA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 11 ILE A 557
ALA A 576
LYS A 578
GLU A 596
ILE A 623
TYR A 627
LEU A 628
ASP A 694
 STU  A   1 (-4.1A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.4A)
STU  A   1 (-4.5A)
STU  A   1 (-3.5A)
 0.84A 4qmsA-3ppzA:
31.0		 4qmsA-3ppzA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 GLY A 558
VAL A 565
ALA A 576
TYR A 627
LEU A 628
LEU A 683
 STU  A   1 (-3.2A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.4A)
STU  A   1 (-4.5A)
STU  A   1 (-4.3A)
 0.54A 4qmzA-3ppzA:
30.6		 4qmzA-3ppzA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 ILE A 557
GLY A 558
VAL A 565
ALA A 576
TYR A 627
LEU A 628
 STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.4A)
STU  A   1 (-4.5A)
 0.63A 4qmzA-3ppzA:
30.6		 4qmzA-3ppzA:
28.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		5 / 12 ALA A 576
GLU A 596
MET A 600
LEU A 665
ARG A 675
 STU  A   1 (-3.3A)
None
None
None
SEP  A 710 ( 3.6A)
 1.02A 4qrcA-3ppzA:
29.1		 4qrcA-3ppzA:
33.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 ALA A 576
LYS A 578
GLU A 596
MET A 600
THR A 625
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.3A)
 0.60A 4r7iA-3ppzA:
27.9		 4r7iA-3ppzA:
33.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		5 / 10 ILE A 557
ALA A 576
LYS A 578
THR A 625
LEU A 683
 STU  A   1 (-4.1A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
STU  A   1 (-4.1A)
STU  A   1 (-4.3A)
 0.65A 4rz7A-3ppzA:
8.6		 4rz7A-3ppzA:
16.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 ALA A 576
LYS A 578
ILE A 623
THR A 625
SER A 632
PHE A 695
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.1A)
STU  A   1 ( 4.3A)
None
 0.84A 4rzvA-3ppzA:
8.3		 4rzvA-3ppzA:
36.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 VAL A 565
ALA A 576
LYS A 578
THR A 625
SER A 632
PHE A 695
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
STU  A   1 (-4.1A)
STU  A   1 ( 4.3A)
None
 1.00A 4rzvB-3ppzA:
29.3		 4rzvB-3ppzA:
36.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		5 / 12 ALA A 576
GLU A 596
MET A 600
HIS A 674
LEU A 683
 STU  A   1 (-3.3A)
None
None
None
STU  A   1 (-4.3A)
 0.53A 4tyjA-3ppzA:
28.5		 4tyjA-3ppzA:
31.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 ALA A 576
LYS A 578
GLY A 631
HIS A 674
LEU A 683
CYH A 693
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
STU  A   1 (-3.2A)
None
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.67A 4u0iA-3ppzA:
28.1		 4u0iA-3ppzA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 ALA A 576
LYS A 578
THR A 625
GLY A 631
HIS A 674
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
None
STU  A   1 (-4.3A)
 0.38A 4u0iA-3ppzA:
28.1		 4u0iA-3ppzA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 11 GLY A 560
VAL A 565
ALA A 576
TYR A 627
GLY A 631
ASN A 681
LEU A 683
ASP A 694
 None
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.6A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.45A 4u5jA-3ppzA:
32.3		 4u5jA-3ppzA:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		5 / 12 ALA A 576
GLU A 596
MET A 600
LEU A 665
HIS A 674
 STU  A   1 (-3.3A)
None
None
None
None
 0.66A 4v01A-3ppzA:
27.9		 4v01A-3ppzA:
31.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		5 / 12 ALA A 576
GLU A 596
MET A 600
LEU A 665
HIS A 674
 STU  A   1 (-3.3A)
None
None
None
None
 0.59A 4v01B-3ppzA:
28.6		 4v01B-3ppzA:
31.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		4 / 8 LYS A 578
MET A 600
TYR A 627
LEU A 683
 STU  A   1 (-3.5A)
None
STU  A   1 (-4.4A)
STU  A   1 (-4.3A)
 0.53A 4v04A-3ppzA:
27.8		 4v04A-3ppzA:
31.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 ALA A 576
LYS A 578
GLU A 596
MET A 600
THR A 625
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.78A 4wkqA-3ppzA:
30.7		 4wkqA-3ppzA:
29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 ALA A 576
LYS A 578
MET A 600
VAL A 609
ILE A 623
THR A 625
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.59A 4xeyA-3ppzA:
31.6		 4xeyA-3ppzA:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 VAL A 565
ALA A 576
MET A 600
VAL A 609
ILE A 623
THR A 625
GLY A 631
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.42A 4xeyA-3ppzA:
31.6		 4xeyA-3ppzA:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 VAL A 565
ALA A 576
MET A 600
VAL A 609
ILE A 623
THR A 625
GLY A 631
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.39A 4xeyB-3ppzA:
31.1		 4xeyB-3ppzA:
29.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 ALA A 576
LYS A 578
GLU A 596
MET A 600
VAL A 609
THR A 625
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.84A 4xliA-3ppzA:
32.3		 4xliA-3ppzA:
34.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 ALA A 576
LYS A 578
MET A 600
VAL A 609
THR A 625
TYR A 627
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.68A 4xliA-3ppzA:
32.3		 4xliA-3ppzA:
34.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		9 / 12 ALA A 576
LYS A 578
MET A 600
VAL A 609
ILE A 623
THR A 625
TYR A 627
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.52A 4xliB-3ppzA:
32.1		 4xliB-3ppzA:
34.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		5 / 12 ALA A 576
LYS A 578
THR A 625
ASP A 694
PHE A 695
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
STU  A   1 (-4.1A)
STU  A   1 (-3.5A)
None
 0.85A 4xv2B-3ppzA:
29.7		 4xv2B-3ppzA:
38.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 ALA A 576
LYS A 578
GLU A 596
MET A 600
THR A 625
TYR A 627
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.62A 5bvwA-3ppzA:
27.9		 5bvwA-3ppzA:
34.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		5 / 12 VAL A 565
ALA A 576
THR A 625
GLY A 631
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.47A 5h2uA-3ppzA:
29.0		 5h2uA-3ppzA:
30.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 VAL A 565
ALA A 576
ILE A 623
THR A 625
GLY A 631
LEU A 683
ASP A 694
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.66A 5h2uB-3ppzA:
29.2		 5h2uB-3ppzA:
30.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 VAL A 565
ALA A 576
ILE A 623
GLY A 631
LEU A 683
ASP A 694
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.58A 5h2uD-3ppzA:
29.2		 5h2uD-3ppzA:
30.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 VAL A 565
ALA A 576
THR A 625
GLY A 631
LEU A 683
ASP A 694
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.56A 5h2uD-3ppzA:
29.2		 5h2uD-3ppzA:
30.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 VAL A 565
ALA A 576
ILE A 623
THR A 625
CYH A 693
PHE A 695
GLY A 696
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
STU  A   1 (-4.1A)
STU  A   1 (-3.5A)
None
None
 1.07A 5hesA-3ppzA:
10.3		 5hesA-3ppzA:
35.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 VAL A 565
ALA A 576
ILE A 623
THR A 625
TYR A 627
CYH A 693
PHE A 695
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.5A)
None
 0.86A 5hesA-3ppzA:
10.3		 5hesA-3ppzA:
35.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		4 / 6 LYS A 578
PHE A 611
SER A 632
ASP A 694
 STU  A   1 (-3.5A)
None
STU  A   1 ( 4.3A)
STU  A   1 (-3.5A)
 0.45A 5hesA-3ppzA:
10.3		 5hesA-3ppzA:
35.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 VAL A 565
ALA A 576
LYS A 578
ILE A 623
THR A 625
TYR A 627
CYH A 693
GLY A 696
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.5A)
None
 1.02A 5hesB-3ppzA:
29.4		 5hesB-3ppzA:
35.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 VAL A 565
ALA A 576
LYS A 578
ILE A 623
THR A 625
TYR A 627
CYH A 693
PHE A 695
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.5A)
None
 0.87A 5hesB-3ppzA:
29.4		 5hesB-3ppzA:
35.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		4 / 7 ILE A 557
PHE A 611
ILE A 623
PHE A 695
 STU  A   1 (-4.1A)
None
None
None
 1.00A 5hieC-3ppzA:
28.1		 5hieC-3ppzA:
38.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		4 / 8 ILE A 557
GLY A 558
PHE A 611
PHE A 695
 STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
None
None
 0.90A 5hieD-3ppzA:
28.0		 5hieD-3ppzA:
38.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 ILE A 557
ALA A 576
LYS A 578
ILE A 623
THR A 625
TYR A 627
GLY A 631
LEU A 683
 STU  A   1 (-4.1A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.61A 5i9xA-3ppzA:
29.1		 5i9xA-3ppzA:
31.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 ILE A 557
ALA A 576
LYS A 578
MET A 600
THR A 625
TYR A 627
GLY A 631
LEU A 683
 STU  A   1 (-4.1A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.71A 5i9yA-3ppzA:
28.8		 5i9yA-3ppzA:
31.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		4 / 7 GLY A 558
GLY A 560
LYS A 578
LEU A 580
 STU  A   1 (-3.2A)
None
STU  A   1 (-3.5A)
None
 0.74A 5izfA-3ppzA:
25.8		 5izfA-3ppzA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		4 / 7 GLY A 558
GLY A 560
SER A 561
LEU A 580
 STU  A   1 (-3.2A)
None
None
None
 0.48A 5izfA-3ppzA:
25.8		 5izfA-3ppzA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 7 GLY A 558
GLY A 560
SER A 561
GLY A 563
VAL A 565
LEU A 580
 STU  A   1 (-3.2A)
None
None
None
STU  A   1 (-4.9A)
None
 0.65A 5izjB-3ppzA:
26.1		 5izjB-3ppzA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		5 / 7 GLY A 558
GLY A 560
SER A 561
VAL A 565
LEU A 580
 STU  A   1 (-3.2A)
None
None
STU  A   1 (-4.9A)
None
 0.66A 5izjA-3ppzA:
26.3		 5izjA-3ppzA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		5 / 7 GLY A 558
GLY A 560
VAL A 565
LYS A 578
LEU A 580
 STU  A   1 (-3.2A)
None
STU  A   1 (-4.9A)
STU  A   1 (-3.5A)
None
 0.81A 5izjA-3ppzA:
26.3		 5izjA-3ppzA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		5 / 7 GLY A 558
GLY A 560
VAL A 565
LYS A 578
ASP A 694
 STU  A   1 (-3.2A)
None
STU  A   1 (-4.9A)
STU  A   1 (-3.5A)
STU  A   1 (-3.5A)
 0.84A 5j5xA-3ppzA:
26.1		 5j5xA-3ppzA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 ILE A 557
GLY A 558
VAL A 565
ALA A 576
VAL A 609
LEU A 683
 STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
STU  A   1 (-4.3A)
 0.68A 5l2iA-3ppzA:
6.5		 5l2iA-3ppzA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 GLU A 555
ILE A 557
GLY A 558
VAL A 565
ALA A 576
LYS A 578
GLU A 596
GLY A 631
 None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-3.2A)
 1.03A 5mafA-3ppzA:
26.0		 5mafA-3ppzA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 ILE A 557
GLY A 558
VAL A 565
ALA A 576
LYS A 578
GLU A 596
TYR A 627
GLY A 631
 STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
 0.80A 5mafA-3ppzA:
26.0		 5mafA-3ppzA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		5 / 12 ALA A 576
MET A 600
VAL A 609
HIS A 674
LEU A 683
 STU  A   1 (-3.3A)
None
None
None
STU  A   1 (-4.3A)
 0.58A 5mo4A-3ppzA:
7.1		 5mo4A-3ppzA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		4 / 8 ALA A 576
GLU A 596
LEU A 683
ASP A 694
 STU  A   1 (-3.3A)
None
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.45A 5owrA-3ppzA:
22.8		 5owrA-3ppzA:
27.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 GLY A 558
VAL A 565
ALA A 576
THR A 625
GLY A 631
LEU A 683
PHE A 695
 STU  A   1 (-3.2A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
None
 1.40A 5p9iA-3ppzA:
29.8		 5p9iA-3ppzA:
30.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 VAL A 565
ALA A 576
ILE A 623
THR A 625
GLY A 631
LEU A 683
PHE A 695
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
None
 0.96A 5p9iA-3ppzA:
29.8		 5p9iA-3ppzA:
30.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 GLU A 555
ALA A 576
GLU A 596
MET A 600
VAL A 609
GLY A 631
LEU A 683
 None
STU  A   1 (-3.3A)
None
None
None
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.81A 5te0A-3ppzA:
26.5		 5te0A-3ppzA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 GLU A 555
ALA A 576
GLU A 596
TYR A 627
GLY A 631
ASP A 694
 None
STU  A   1 (-3.3A)
None
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-3.5A)
 1.14A 5vc3A-3ppzA:
25.7		 5vc3A-3ppzA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 GLU A 555
ILE A 557
GLY A 558
ALA A 576
GLU A 596
TYR A 627
GLY A 631
 None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-3.3A)
None
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
 1.24A 5vc3A-3ppzA:
25.7		 5vc3A-3ppzA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 ALA A 576
LYS A 578
GLU A 596
VAL A 609
THR A 625
GLY A 631
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
 1.06A 5vcvA-3ppzA:
26.6		 5vcvA-3ppzA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		4 / 6 TRP A 717
SER A 679
ARG A 635
TYR A 634
 None
None
STU  A   1 (-2.9A)
None
 1.38A 5x7pA-3ppzA:
undetectable		 5x7pA-3ppzA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		4 / 6 TRP A 717
SER A 679
ARG A 635
TYR A 634
 None
None
STU  A   1 (-2.9A)
None
 1.40A 5x7pB-3ppzA:
2.2		 5x7pB-3ppzA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		4 / 6 TRP A 717
SER A 679
ARG A 635
TYR A 634
 None
None
STU  A   1 (-2.9A)
None
 1.42A 5x7qA-3ppzA:
3.0		 5x7qA-3ppzA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		4 / 6 TRP A 717
SER A 679
ARG A 635
TYR A 634
 None
None
STU  A   1 (-2.9A)
None
 1.43A 5x7qB-3ppzA:
2.2		 5x7qB-3ppzA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		4 / 6 TRP A 717
SER A 679
ARG A 635
TYR A 634
 None
None
STU  A   1 (-2.9A)
None
 1.41A 5x7rA-3ppzA:
3.3		 5x7rA-3ppzA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		4 / 6 TRP A 717
SER A 679
ARG A 635
TYR A 634
 None
None
STU  A   1 (-2.9A)
None
 1.41A 5x7rB-3ppzA:
2.0		 5x7rB-3ppzA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 ALA A 576
LYS A 578
GLU A 596
GLY A 631
LEU A 683
CYH A 693
ASP A 694
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
STU  A   1 (-3.5A)
 0.93A 5y7zB-3ppzA:
26.0		 5y7zB-3ppzA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 VAL A 565
ALA A 576
LYS A 578
GLU A 596
THR A 625
GLY A 631
LEU A 683
ASP A 694
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.70A 5y80A-3ppzA:
24.8		 5y80A-3ppzA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		3 / 3 TYR A 627
LEU A 683
ASP A 694
 STU  A   1 (-4.4A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.49A 5zv2B-3ppzA:
27.9		 5zv2B-3ppzA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		3 / 3 TYR A 656
PRO A 807
LEU A 808
 None
 0.95A 6beoA-3ppzA:
undetectable		 6beoA-3ppzA:
5.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 ALA A 576
LYS A 578
GLU A 596
MET A 600
THR A 625
TYR A 627
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.61A 6bsdA-3ppzA:
27.6		 6bsdA-3ppzA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 VAL A 565
ALA A 576
LYS A 578
THR A 625
TYR A 627
GLY A 631
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.59A 6bsdA-3ppzA:
27.6		 6bsdA-3ppzA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 ALA A 576
LYS A 578
GLU A 596
MET A 600
VAL A 609
ILE A 623
THR A 625
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.3A)
 0.73A 6hd4A-3ppzA:
28.3		 6hd4A-3ppzA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 VAL A 565
ALA A 576
LYS A 578
MET A 600
VAL A 609
ILE A 623
THR A 625
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.3A)
 0.75A 6hd4A-3ppzA:
28.3		 6hd4A-3ppzA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 ALA A 576
GLU A 596
MET A 600
VAL A 609
ILE A 623
THR A 625
LEU A 683
 STU  A   1 (-3.3A)
None
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.3A)
 0.63A 6hd4B-3ppzA:
28.4		 6hd4B-3ppzA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 ALA A 576
LYS A 578
GLU A 596
MET A 600
VAL A 609
ILE A 623
THR A 625
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
None
STU  A   1 (-4.1A)
 0.67A 6hd4B-3ppzA:
28.4		 6hd4B-3ppzA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 ALA A 576
LYS A 578
MET A 600
VAL A 609
ILE A 623
THR A 625
LEU A 628
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.5A)
 1.15A 6hd4B-3ppzA:
28.4		 6hd4B-3ppzA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 VAL A 565
ALA A 576
LYS A 578
MET A 600
VAL A 609
ILE A 623
THR A 625
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
STU  A   1 (-4.1A)
 0.64A 6hd4B-3ppzA:
28.4		 6hd4B-3ppzA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		7 / 12 VAL A 565
ALA A 576
MET A 600
VAL A 609
ILE A 623
THR A 625
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.3A)
 0.75A 6hd4B-3ppzA:
28.4		 6hd4B-3ppzA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 ALA A 576
LYS A 578
GLU A 596
MET A 600
VAL A 609
ILE A 623
THR A 625
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.3A)
 0.73A 6hd6A-3ppzA:
21.0		 6hd6A-3ppzA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		8 / 12 VAL A 565
ALA A 576
LYS A 578
MET A 600
VAL A 609
ILE A 623
THR A 625
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.3A)
 0.75A 6hd6A-3ppzA:
21.0		 6hd6A-3ppzA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1
(Arabidopsis
thaliana) 		6 / 12 ALA A 576
GLU A 596
MET A 600
VAL A 609
THR A 625
LEU A 683
 STU  A   1 (-3.3A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.3A)
 0.58A 6hd6B-3ppzA:
28.4		 6hd6B-3ppzA:
12.67