SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pqs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		4 / 8 GLY A 438
GLY A 521
LEU A 503
GLY A 505
 None
None
None
GOL  A 529 ( 4.3A)
 0.75A 1d0vA-3pqsA:
undetectable		 1d0vA-3pqsA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		4 / 8 GLY A 438
GLY A 521
LEU A 503
GLY A 505
 None
None
None
GOL  A 529 ( 4.3A)
 0.75A 1jhaA-3pqsA:
undetectable		 1jhaA-3pqsA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		3 / 3 ARG A 221
ILE A 193
TRP A 152
 GOL  A3968 (-3.5A)
None
None
 1.21A 1qomA-3pqsA:
undetectable		 1qomA-3pqsA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		5 / 5 LEU A  87
ASP A 125
GLY A 122
ALA A  91
ILE A  90
 None
 1.19A 2aohB-3pqsA:
undetectable		 2aohB-3pqsA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		5 / 12 GLY A 463
ALA A 454
ASP A 455
VAL A 429
GLY A 460
 None
 1.09A 2avsB-3pqsA:
undetectable		 2avsB-3pqsA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		6 / 12 GLY A 463
ALA A 454
ASP A 455
VAL A 429
ILE A 456
GLY A 460
 None
 1.18A 2bpxB-3pqsA:
undetectable		 2bpxB-3pqsA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		5 / 12 GLY A 463
ALA A 454
VAL A 429
ILE A 456
GLY A 460
 None
 0.92A 2q5kB-3pqsA:
undetectable		 2q5kB-3pqsA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		3 / 3 ASN A  58
ARG A 179
ASP A 186
 None
 0.83A 2qe6A-3pqsA:
undetectable		 2qe6A-3pqsA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		3 / 3 ASN A  58
ARG A 179
ASP A 186
 None
 0.81A 2qe6B-3pqsA:
undetectable		 2qe6B-3pqsA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		3 / 3 TYR A  51
GLU A  40
ASP A  30
 None
 0.81A 3bxoA-3pqsA:
undetectable		 3bxoA-3pqsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		3 / 3 TYR A  51
GLU A  40
ASP A  30
 None
 0.85A 3bxoB-3pqsA:
2.3		 3bxoB-3pqsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_B_ZMRB601_1
(NEURAMINIDASE)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		5 / 12 ARG A 221
GLU A 170
ASP A 244
ARG A 164
SER A 276
 GOL  A3968 (-3.5A)
GOL  A3968 (-3.1A)
GOL  A 533 ( 4.2A)
None
None
 1.45A 4b7qB-3pqsA:
undetectable		 4b7qB-3pqsA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		5 / 12 ILE A 389
THR A 384
GLY A 504
VAL A 429
VAL A 436
 None
 1.06A 4c9lA-3pqsA:
undetectable		 4c9lA-3pqsA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		5 / 12 ILE A 389
THR A 384
GLY A 504
VAL A 429
VAL A 436
 None
 1.05A 4c9lB-3pqsA:
undetectable		 4c9lB-3pqsA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		5 / 12 ILE A 389
THR A 384
GLY A 504
VAL A 429
VAL A 436
 None
 1.04A 4c9oA-3pqsA:
undetectable		 4c9oA-3pqsA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		5 / 12 ILE A 389
THR A 384
GLY A 504
VAL A 429
VAL A 436
 None
 1.05A 4c9oB-3pqsA:
undetectable		 4c9oB-3pqsA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		3 / 3 LYS A 523
TYR A 397
ARG A 524
 None
None
GOL  A 541 ( 3.9A)
 1.35A 4gc9A-3pqsA:
undetectable		 4gc9A-3pqsA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		5 / 11 VAL A 436
ALA A 454
GLY A 521
GLY A 493
ASP A 428
 None
None
None
GOL  A 529 (-3.4A)
None
 1.22A 4mm9A-3pqsA:
undetectable		 4mm9A-3pqsA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		5 / 9 VAL A 516
ILE A 350
ALA A 415
THR A 400
ALA A 518
 None
 1.24A 4oqrA-3pqsA:
undetectable		 4oqrA-3pqsA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		4 / 7 ALA A 465
SER A 406
GLY A 517
ALA A 518
 None
 0.87A 4r1zB-3pqsA:
undetectable		 4r1zB-3pqsA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		5 / 11 PHE A 520
VAL A 429
GLY A 505
SER A 425
GLY A 438
 None
None
GOL  A 529 ( 4.3A)
None
None
 1.11A 4xp4A-3pqsA:
undetectable		 4xp4A-3pqsA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		4 / 6 GLY A 133
TYR A 131
ALA A 267
ARG A 232
 None
 1.30A 4yshB-3pqsA:
undetectable		 4yshB-3pqsA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		4 / 6 SER A 425
GLU A 426
GLY A 381
ASP A 297
 None
None
None
GOL  A 529 (-3.0A)
 0.94A 5cdnR-3pqsA:
undetectable
5cdnS-3pqsA:
undetectable		 5cdnR-3pqsA:
22.30
5cdnS-3pqsA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		5 / 12 GLY A 286
GLY A 150
GLY A 283
GLU A 265
ASP A 153
 None
 0.86A 5e9qC-3pqsA:
undetectable		 5e9qC-3pqsA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		5 / 12 GLY A 286
GLY A 150
GLY A 283
GLU A 265
ASP A 153
 None
 0.88A 5eifC-3pqsA:
undetectable		 5eifC-3pqsA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		4 / 5 ASP A 186
VAL A  57
GLY A 177
ALA A 158
 None
 0.92A 5hwaA-3pqsA:
undetectable		 5hwaA-3pqsA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		5 / 12 GLY A 286
GLY A 150
GLY A 283
GLU A 265
ASP A 153
 None
 0.91A 5kqrA-3pqsA:
undetectable		 5kqrA-3pqsA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		3 / 3 SER A 112
TYR A 131
TYR A 130
 None
 0.75A 5lakA-3pqsA:
undetectable
5lakI-3pqsA:
undetectable		 5lakA-3pqsA:
19.85
5lakI-3pqsA:
1.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		3 / 3 SER A 112
TYR A 131
TYR A 130
 None
 0.76A 5lakC-3pqsA:
undetectable
5lakJ-3pqsA:
undetectable		 5lakC-3pqsA:
19.85
5lakJ-3pqsA:
1.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		5 / 12 ILE A 116
GLY A 127
PHE A 278
ALA A 185
VAL A 182
 None
 1.19A 5n0oA-3pqsA:
undetectable		 5n0oA-3pqsA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		4 / 7 ASN A 144
PHE A 200
ILE A 146
GLY A 286
 None
 1.00A 5nzyA-3pqsA:
undetectable		 5nzyA-3pqsA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		5 / 12 VAL A 436
VAL A 516
PHE A 427
PHE A 461
PHE A 507
 None
 1.43A 6becA-3pqsA:
undetectable
6becB-3pqsA:
undetectable
6becC-3pqsA:
undetectable		 6becA-3pqsA:
22.42
6becB-3pqsA:
22.42
6becC-3pqsA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		6 / 12 GLY A 463
ALA A 454
ASP A 455
VAL A 429
ILE A 456
GLY A 460
 None
 1.09A 6dj1B-3pqsA:
undetectable		 6dj1B-3pqsA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		6 / 12 GLY A 463
ALA A 454
ASP A 455
VAL A 429
ILE A 456
GLY A 460
 None
 1.11A 6dj2B-3pqsA:
undetectable		 6dj2B-3pqsA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		3 / 3 ARG A 164
PHE A 171
GLY A 177
 None
 0.69A 6fgdA-3pqsA:
undetectable		 6fgdA-3pqsA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3pqs TRANSFERRIN-BINDING
PROTEIN
(Actinobacillus
pleuropneumoniae) 		3 / 3 ARG A 383
PHE A 361
PHE A 461
 GOL  A 529 (-4.2A)
None
None
 1.05A 6nknC-3pqsA:
undetectable
6nknJ-3pqsA:
undetectable		 6nknC-3pqsA:
19.01
6nknJ-3pqsA:
7.10