SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pqv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 3pqv RCL1 PROTEIN
(Kluyveromyces
lactis) 		3 / 3 ARG A  14
ARG A  36
ARG A 319
 None
None
TAR  A 401 ( 3.9A)
 0.93A 1l7fA-3pqvA:
undetectable		 1l7fA-3pqvA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 3pqv RCL1 PROTEIN
(Kluyveromyces
lactis) 		3 / 3 ARG A  14
ARG A  36
ARG A 319
 None
None
TAR  A 401 ( 3.9A)
 0.94A 1l7hA-3pqvA:
undetectable		 1l7hA-3pqvA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3pqv RCL1 PROTEIN
(Kluyveromyces
lactis) 		5 / 12 ALA A  23
ILE A  35
ARG A  36
LEU A  44
THR A  24
 None
 1.13A 1rx8A-3pqvA:
undetectable		 1rx8A-3pqvA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 3pqv RCL1 PROTEIN
(Kluyveromyces
lactis) 		5 / 11 LEU A 215
GLY A 270
ALA A 271
ASP A 268
VAL A 214
 None
 1.12A 2fxdA-3pqvA:
undetectable		 2fxdA-3pqvA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_1
(PROTEASE RETROPEPSIN)		 3pqv RCL1 PROTEIN
(Kluyveromyces
lactis) 		5 / 12 LEU A 136
ALA A  99
ILE A 129
ALA A 131
ILE A 132
 None
 0.83A 2rkfA-3pqvA:
undetectable		 2rkfA-3pqvA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 3pqv RCL1 PROTEIN
(Kluyveromyces
lactis) 		5 / 12 LEU A 136
ALA A  99
ILE A 129
ALA A 131
ILE A 132
 None
 0.83A 2rkfB-3pqvA:
undetectable		 2rkfB-3pqvA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3pqv RCL1 PROTEIN
(Kluyveromyces
lactis) 		5 / 6 GLY A 235
GLY A 156
GLY A 163
GLY A 161
GLY A 119
 None
 0.86A 3bogA-3pqvA:
undetectable
3bogC-3pqvA:
undetectable		 3bogA-3pqvA:
undetectable
3bogC-3pqvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3pqv RCL1 PROTEIN
(Kluyveromyces
lactis) 		5 / 6 GLY A 235
GLY A 156
GLY A 163
GLY A 161
GLY A 119
 None
 0.84A 3bogB-3pqvA:
undetectable
3bogD-3pqvA:
undetectable		 3bogB-3pqvA:
undetectable
3bogD-3pqvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3pqv RCL1 PROTEIN
(Kluyveromyces
lactis) 		4 / 4 LYS A 142
GLN A 291
ILE A 311
LEU A 182
 None
 1.12A 3qt0A-3pqvA:
undetectable		 3qt0A-3pqvA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_B_DXCB92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3pqv RCL1 PROTEIN
(Kluyveromyces
lactis) 		4 / 5 VAL A 145
ARG A 146
LYS A 110
LYS A 112
 None
 1.33A 3rv5A-3pqvA:
undetectable
3rv5B-3pqvA:
undetectable		 3rv5A-3pqvA:
12.24
3rv5B-3pqvA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_C_BEZC1_0
(HEME-BINDING PROTEIN
HUTZ)		 3pqv RCL1 PROTEIN
(Kluyveromyces
lactis) 		4 / 5 TYR A 298
PHE A 108
PRO A 107
LEU A 105
 None
 1.25A 3tgvC-3pqvA:
undetectable		 3tgvC-3pqvA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 3pqv RCL1 PROTEIN
(Kluyveromyces
lactis) 		6 / 12 ILE A 129
ASP A 130
GLY A 128
SER A 122
THR A 152
GLY A 241
 None
 1.32A 3uboA-3pqvA:
undetectable		 3uboA-3pqvA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 3pqv RCL1 PROTEIN
(Kluyveromyces
lactis) 		5 / 10 ILE A  80
LEU A 105
GLY A  61
SER A  62
PHE A  75
 None
 0.98A 4bwlC-3pqvA:
undetectable		 4bwlC-3pqvA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 3pqv RCL1 PROTEIN
(Kluyveromyces
lactis) 		4 / 5 LEU A  44
GLY A  43
ILE A  32
LYS A  31
 None
 1.04A 4ma8C-3pqvA:
undetectable		 4ma8C-3pqvA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3pqv RCL1 PROTEIN
(Kluyveromyces
lactis) 		5 / 12 ALA A  23
ILE A  35
ARG A  36
LEU A  44
THR A  24
 None
 1.14A 4x5fB-3pqvA:
undetectable		 4x5fB-3pqvA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3pqv RCL1 PROTEIN
(Kluyveromyces
lactis) 		5 / 12 GLY A 302
TYR A 298
ILE A 351
THR A 178
GLY A 144
 None
 1.00A 5d4uA-3pqvA:
undetectable		 5d4uA-3pqvA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3pqv RCL1 PROTEIN
(Kluyveromyces
lactis) 		5 / 12 GLY A 302
TYR A 298
ILE A 351
THR A 178
GLY A 144
 None
 0.99A 5d4uB-3pqvA:
undetectable		 5d4uB-3pqvA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3pqv RCL1 PROTEIN
(Kluyveromyces
lactis) 		5 / 12 GLY A 302
TYR A 298
ILE A 351
THR A 178
GLY A 144
 None
 1.01A 5d4uC-3pqvA:
undetectable		 5d4uC-3pqvA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3pqv RCL1 PROTEIN
(Kluyveromyces
lactis) 		5 / 12 ALA A 127
GLY A 192
GLY A 135
LEU A 136
GLY A 241
 None
PEG  A 410 ( 4.8A)
None
None
None
 1.20A 5i71A-3pqvA:
undetectable		 5i71A-3pqvA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3pqv RCL1 PROTEIN
(Kluyveromyces
lactis) 		5 / 12 ALA A 127
GLY A 192
GLY A 135
LEU A 136
GLY A 241
 None
PEG  A 410 ( 4.8A)
None
None
None
 1.24A 5i75A-3pqvA:
undetectable		 5i75A-3pqvA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 3pqv RCL1 PROTEIN
(Kluyveromyces
lactis) 		5 / 12 PRO A 201
VAL A 204
ASN A 205
ILE A 208
LYS A 212
 None
 0.73A 5j2tC-3pqvA:
undetectable		 5j2tC-3pqvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3pqv RCL1 PROTEIN
(Kluyveromyces
lactis) 		5 / 12 GLY A 119
LEU A 103
GLY A 128
SER A 122
ILE A 129
 None
 1.08A 5vooB-3pqvA:
undetectable		 5vooB-3pqvA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3pqv RCL1 PROTEIN
(Kluyveromyces
lactis) 		5 / 12 GLY A 119
LEU A 103
GLY A 128
SER A 122
ILE A 129
 None
 1.10A 5vooD-3pqvA:
undetectable		 5vooD-3pqvA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3pqv RCL1 PROTEIN
(Kluyveromyces
lactis) 		5 / 12 GLY A 119
LEU A 103
GLY A 128
SER A 122
ILE A 129
 None
 1.16A 5vooF-3pqvA:
undetectable		 5vooF-3pqvA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA807_0
(GEPHYRIN)		 3pqv RCL1 PROTEIN
(Kluyveromyces
lactis) 		4 / 4 PRO A 101
LEU A 105
VAL A  20
ARG A  17
 None
None
None
TAR  A 401 (-4.2A)
 1.30A 6fgdA-3pqvA:
undetectable		 6fgdA-3pqvA:
21.76