SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pqy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 3pqy ALPHA CHAIN OF THE
6218-TCR
BETA CHAIN OF THE
6218-TCR
(Homo
sapiens;
Mus
musculus;
Homo
sapiens;
Mus
musculus) 		4 / 7 ILE E  55
TYR E  42
PHE E 114
PHE D 116
 None
 1.23A 1e71M-3pqyE:
undetectable		 1e71M-3pqyE:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 3pqy ALPHA CHAIN OF THE
6218-TCR
BETA CHAIN OF THE
6218-TCR
(Homo
sapiens;
Mus
musculus;
Homo
sapiens;
Mus
musculus) 		4 / 7 ILE E  55
TYR E  42
PHE E 114
PHE D 116
 None
 1.22A 1e72M-3pqyE:
undetectable		 1e72M-3pqyE:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 3pqy ALPHA CHAIN OF THE
6218-TCR
(Homo
sapiens;
Mus
musculus) 		3 / 3 ALA D 197
VAL D 147
TRP D 190
 None
 0.72A 1gmkA-3pqyD:
undetectable
1gmkB-3pqyD:
undetectable		 1gmkA-3pqyD:
7.50
1gmkB-3pqyD:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 3pqy ALPHA CHAIN OF THE
6218-TCR
(Homo
sapiens;
Mus
musculus) 		3 / 3 ALA D 197
VAL D 147
TRP D 190
 None
 0.77A 1gmkC-3pqyD:
undetectable
1gmkD-3pqyD:
undetectable		 1gmkC-3pqyD:
7.50
1gmkD-3pqyD:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 3pqy ALPHA CHAIN OF THE
6218-TCR
(Homo
sapiens;
Mus
musculus) 		4 / 6 LEU D  89
ILE D  90
MET D  78
VAL D 174
 None
 0.99A 2ygoA-3pqyD:
undetectable		 2ygoA-3pqyD:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3pqy BETA CHAIN OF THE
6218-TCR
(Homo
sapiens;
Mus
musculus) 		4 / 5 GLN E 242
THR E 241
THR E 121
LEU E 126
 None
 1.33A 3ce6A-3pqyE:
undetectable		 3ce6A-3pqyE:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3pqy ALPHA CHAIN OF THE
6218-TCR
(Homo
sapiens;
Mus
musculus) 		4 / 5 LEU D  81
THR D  54
HIS D  25
LEU D 106
 None
 1.21A 3ce6D-3pqyD:
undetectable		 3ce6D-3pqyD:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 3pqy ALPHA CHAIN OF THE
6218-TCR
BETA CHAIN OF THE
6218-TCR
(Homo
sapiens;
Mus
musculus) 		4 / 7 TYR D  33
TYR D  40
TYR D  42
TYR E  40
 None
 1.15A 3ku9B-3pqyD:
undetectable		 3ku9B-3pqyD:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 3pqy ALPHA CHAIN OF THE
6218-TCR
BETA CHAIN OF THE
6218-TCR
(Homo
sapiens;
Mus
musculus;
Homo
sapiens;
Mus
musculus) 		4 / 8 TYR E  42
SER E 107
SER D 107
LEU D 114
 None
 0.98A 3lsfH-3pqyE:
undetectable		 3lsfH-3pqyE:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 3pqy ALPHA CHAIN OF THE
6218-TCR
BETA CHAIN OF THE
6218-TCR
(Homo
sapiens;
Mus
musculus) 		3 / 3 GLN E 112
PHE E 114
TYR D  42
 None
 0.99A 3ucjA-3pqyE:
undetectable		 3ucjA-3pqyE:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 3pqy ALPHA CHAIN OF THE
6218-TCR
(Homo
sapiens;
Mus
musculus) 		4 / 7 PRO D  22
SER D  10
GLU D  12
THR D 157
 None
 1.31A 4uacA-3pqyD:
undetectable		 4uacA-3pqyD:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 3pqy ALPHA CHAIN OF THE
6218-TCR
(Homo
sapiens;
Mus
musculus) 		4 / 6 ILE D 105
GLY D  30
ASN D  31
ILE D  39
 None
 0.76A 5j4nB-3pqyD:
undetectable		 5j4nB-3pqyD:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3pqy BETA CHAIN OF THE
6218-TCR
(Homo
sapiens;
Mus
musculus) 		4 / 4 GLN E 242
THR E 241
THR E 121
LEU E 126
 None
 1.38A 5m5kA-3pqyE:
undetectable		 5m5kA-3pqyE:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3pqy BETA CHAIN OF THE
6218-TCR
(Homo
sapiens;
Mus
musculus) 		4 / 4 GLN E 242
THR E 241
THR E 121
LEU E 126
 None
 1.38A 5m5kC-3pqyE:
undetectable		 5m5kC-3pqyE:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 3pqy ALPHA CHAIN OF THE
6218-TCR
(Homo
sapiens;
Mus
musculus) 		5 / 12 PHE D 150
ILE D 169
ASN D 203
THR D 211
VAL D 134
 None
 0.97A 5uvmB-3pqyD:
undetectable		 5uvmB-3pqyD:
19.90