SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pr4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 3pr4 DNA POLYMERASE IV
(Sulfolobus
solfataricus) 		4 / 7 SER A 315
PHE A 266
ALA A 311
PHE A 337
 None
 1.17A 1fxvA-3pr4A:
undetectable
1fxvB-3pr4A:
2.1		 1fxvA-3pr4A:
18.55
1fxvB-3pr4A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 3pr4 DNA POLYMERASE IV
(Sulfolobus
solfataricus) 		5 / 11 VAL A  32
GLU A  16
ALA A  12
ILE A 104
ASP A 105
 None
None
ATP  A 342 (-3.1A)
None
ATP  A 342 ( 3.0A)
 1.05A 2admB-3pr4A:
undetectable		 2admB-3pr4A:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3pr4 DNA POLYMERASE IV
(Sulfolobus
solfataricus) 		5 / 12 GLY A 162
ARG A 119
ILE A 111
GLY A 143
ALA A 121
 None
 0.99A 3sudC-3pr4A:
undetectable		 3sudC-3pr4A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 3pr4 DNA POLYMERASE IV
(Sulfolobus
solfataricus) 		3 / 3 SER A 145
TYR A 118
ASP A 231
 None
 0.84A 4rp8C-3pr4A:
2.0		 4rp8C-3pr4A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3pr4 DNA POLYMERASE IV
(Sulfolobus
solfataricus) 		5 / 12 GLY A 143
ALA A 121
ILE A 166
LYS A 146
ALA A 107
 None
 1.15A 5bw4B-3pr4A:
undetectable		 5bw4B-3pr4A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3pr4 DNA POLYMERASE IV
(Sulfolobus
solfataricus) 		3 / 3 ARG A 336
ILE A 284
PHE A 337
 None
 0.61A 5kirA-3pr4A:
undetectable		 5kirA-3pr4A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3pr4 DNA POLYMERASE IV
(Sulfolobus
solfataricus) 		5 / 12 ILE A 153
VAL A 171
ASP A 156
ALA A 155
PRO A 184
 None
 0.98A 6bq4B-3pr4A:
undetectable		 6bq4B-3pr4A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 3pr4 DNA POLYMERASE IV
(Sulfolobus
solfataricus) 		5 / 12 GLY A 162
ARG A 119
ILE A 111
GLY A 143
ALA A 121
 None
 0.93A 6c2mD-3pr4A:
undetectable		 6c2mD-3pr4A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3pr4 DNA POLYMERASE IV
(Sulfolobus
solfataricus) 		5 / 11 ALA A 154
TYR A 233
LEU A 228
TYR A 108
ALA A 151
 None
 1.42A 6dk1B-3pr4A:
undetectable		 6dk1B-3pr4A:
19.21