SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3prb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 3prb FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Methanocaldococc
us
jannaschii) 		4 / 6 GLY A 116
ILE A 109
ILE A 111
ASP A 129
 None
 0.81A 3a7eA-3prbA:
undetectable		 3a7eA-3prbA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3prb FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Methanocaldococc
us
jannaschii) 		4 / 6 PHE A 216
ILE A 200
ALA A 201
ALA A 211
 None
 0.80A 3mdrB-3prbA:
undetectable		 3mdrB-3prbA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 3prb FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 PHE A 216
ILE A 200
ALA A 201
ALA A 211
GLY A 177
 None
 0.81A 4enhA-3prbA:
undetectable		 4enhA-3prbA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 3prb FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ILE A 181
PHE A 216
VAL A 156
ILE A 204
 None
 0.89A 4zzbC-3prbA:
undetectable
4zzbD-3prbA:
undetectable		 4zzbC-3prbA:
20.56
4zzbD-3prbA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 3prb FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ILE A 145
ILE A 143
GLU A   3
VAL A   8
ILE A  10
 None
 1.17A 6hloA-3prbA:
undetectable		 6hloA-3prbA:
19.04