SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3prl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bacillus
halodurans) 		4 / 5 ARG A 112
ALA A 171
ASP A 449
GLY A 465
 SO4  A 506 (-3.1A)
None
None
None
 1.14A 1e7cA-3prlA:
undetectable		 1e7cA-3prlA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bacillus
halodurans) 		4 / 6 ILE A  95
PRO A 165
GLU A 109
PHE A 162
 None
 1.35A 1oniA-3prlA:
undetectable
1oniC-3prlA:
undetectable		 1oniA-3prlA:
17.49
1oniC-3prlA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bacillus
halodurans) 		4 / 6 TYR A 288
ILE A  95
GLU A 109
PHE A 162
 None
 1.37A 1oniA-3prlA:
undetectable
1oniC-3prlA:
undetectable		 1oniA-3prlA:
17.49
1oniC-3prlA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bacillus
halodurans) 		5 / 7 TYR A 288
ILE A  95
PRO A 165
GLU A 109
PHE A 162
 None
 1.47A 1oniD-3prlA:
undetectable
1oniE-3prlA:
undetectable		 1oniD-3prlA:
17.49
1oniE-3prlA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bacillus
halodurans) 		4 / 6 SER A 410
SER A 459
LEU A 414
GLY A 413
 None
 0.90A 2j2pA-3prlA:
undetectable
2j2pC-3prlA:
undetectable		 2j2pA-3prlA:
17.40
2j2pC-3prlA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bacillus
halodurans) 		4 / 8 SER A 469
ILE A 466
ASP A 449
ARG A 112
 None
None
None
SO4  A 506 (-3.1A)
 0.90A 2v57A-3prlA:
undetectable		 2v57A-3prlA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bacillus
halodurans) 		4 / 8 SER A 469
ILE A 466
ASP A 449
ARG A 112
 None
None
None
SO4  A 506 (-3.1A)
 0.90A 2v57C-3prlA:
undetectable		 2v57C-3prlA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bacillus
halodurans) 		4 / 8 PHE A 388
GLY A 389
VAL A 391
LEU A 346
 None
 1.06A 3bgdB-3prlA:
3.1		 3bgdB-3prlA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bacillus
halodurans) 		4 / 6 THR A 179
SER A 472
LEU A 471
THR A 474
 None
 0.95A 3deuB-3prlA:
undetectable		 3deuB-3prlA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bacillus
halodurans) 		3 / 3 ASN A 482
ASP A 135
GLN A 136
 None
 0.73A 3eeyC-3prlA:
3.2		 3eeyC-3prlA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bacillus
halodurans) 		3 / 3 ASN A 482
ASP A 135
GLN A 136
 None
 0.72A 3eeyD-3prlA:
3.9		 3eeyD-3prlA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bacillus
halodurans) 		3 / 3 ASN A 482
ASP A 135
GLN A 136
 None
 0.74A 3eeyE-3prlA:
3.1		 3eeyE-3prlA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bacillus
halodurans) 		5 / 8 GLY A 354
ALA A 355
ASP A 375
ASP A 374
THR A 371
 None
 1.47A 3el0A-3prlA:
undetectable		 3el0A-3prlA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bacillus
halodurans) 		3 / 3 ASN A 366
ASP A 336
ARG A 381
 None
 0.91A 3k13A-3prlA:
undetectable		 3k13A-3prlA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bacillus
halodurans) 		5 / 9 LEU A 320
LEU A 392
ILE A 313
ALA A 278
ALA A 285
 None
 0.94A 3mdvA-3prlA:
undetectable		 3mdvA-3prlA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bacillus
halodurans) 		5 / 12 LEU A 320
LEU A 392
ILE A 313
ALA A 278
ALA A 285
 None
 0.94A 3mdvB-3prlA:
undetectable		 3mdvB-3prlA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bacillus
halodurans) 		4 / 6 ARG A 446
THR A 238
ALA A 170
ALA A 171
 None
 1.15A 3ns1C-3prlA:
undetectable		 3ns1C-3prlA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bacillus
halodurans) 		6 / 9 ALA A 114
ASP A 115
ILE A 116
GLY A 108
ILE A 107
LEU A  84
 None
 1.16A 3ogpA-3prlA:
undetectable		 3ogpA-3prlA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bacillus
halodurans) 		5 / 10 LEU A 357
ALA A 350
VAL A 376
ILE A 343
LEU A 373
 None
 1.13A 3ogpB-3prlA:
undetectable		 3ogpB-3prlA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bacillus
halodurans) 		6 / 9 ALA A 114
ASP A 115
ILE A 116
GLY A 108
ILE A 107
LEU A  84
 None
 1.22A 3ogpB-3prlA:
undetectable		 3ogpB-3prlA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bacillus
halodurans) 		6 / 10 ALA A 114
ASP A 115
ILE A 116
GLY A 108
ILE A 107
LEU A  84
 None
 1.20A 3ogqA-3prlA:
undetectable		 3ogqA-3prlA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bacillus
halodurans) 		5 / 12 ALA A 114
ASP A 115
ILE A 116
GLY A 108
ILE A 107
 None
 1.01A 3ogqB-3prlA:
undetectable		 3ogqB-3prlA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bacillus
halodurans) 		5 / 12 VAL A 199
ILE A 173
GLU A  98
ILE A  31
VAL A 183
 None
 1.03A 4a97B-3prlA:
undetectable
4a97C-3prlA:
undetectable		 4a97B-3prlA:
20.63
4a97C-3prlA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bacillus
halodurans) 		4 / 6 GLU A 109
ARG A 112
ASP A 449
ARG A 446
 None
SO4  A 506 (-3.1A)
None
None
 1.31A 4kcnA-3prlA:
undetectable		 4kcnA-3prlA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bacillus
halodurans) 		4 / 6 GLU A 109
ARG A 112
ASP A 449
ARG A 446
 None
SO4  A 506 (-3.1A)
None
None
 1.29A 4kcnB-3prlA:
undetectable		 4kcnB-3prlA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bacillus
halodurans) 		5 / 11 ILE A  43
SER A  42
GLY A  41
GLU A  22
THR A 216
 None
 1.37A 4xt7A-3prlA:
undetectable		 4xt7A-3prlA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EUM_B_ACTB603_0
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bacillus
halodurans) 		4 / 4 ALA A 400
ASN A 401
ARG A 425
ILE A 429
 None
 0.98A 5eumB-3prlA:
0.2		 5eumB-3prlA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bacillus
halodurans) 		5 / 12 ILE A 117
THR A 238
ALA A 124
ILE A 212
PHE A 185
 None
 1.40A 5iwuA-3prlA:
undetectable		 5iwuA-3prlA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Bacillus
halodurans) 		5 / 9 ILE A  43
ILE A  14
ILE A 222
ALA A  45
LEU A  46
 None
 1.08A 5mvmA-3prlA:
undetectable
5mvmE-3prlA:
undetectable		 5mvmA-3prlA:
10.45
5mvmE-3prlA:
10.45