SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pry'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 3pry HEAT SHOCK PROTEIN
HSP 90-BETA
(Homo
sapiens) 		4 / 7 LEU A 419
SER A 417
PHE A 416
LEU A 454
 None
 0.89A 1j8uA-3pryA:
undetectable		 1j8uA-3pryA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3pry HEAT SHOCK PROTEIN
HSP 90-BETA
(Homo
sapiens) 		4 / 7 ILE A 377
PRO A 336
PHE A 433
ASN A 436
 None
 0.77A 1oniG-3pryA:
undetectable
1oniI-3pryA:
undetectable		 1oniG-3pryA:
20.33
1oniI-3pryA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 3pry HEAT SHOCK PROTEIN
HSP 90-BETA
(Homo
sapiens) 		5 / 12 ILE A 400
ILE A 404
LEU A 386
ASN A 389
VAL A 381
 None
 0.94A 2nnhA-3pryA:
undetectable		 2nnhA-3pryA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 3pry HEAT SHOCK PROTEIN
HSP 90-BETA
(Homo
sapiens) 		3 / 3 MET A 466
VAL A 511
GLU A 471
 None
 0.91A 3c6gA-3pryA:
undetectable		 3c6gA-3pryA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 3pry HEAT SHOCK PROTEIN
HSP 90-BETA
(Homo
sapiens) 		4 / 5 TYR A 301
ILE A 408
LEU A 333
PHE A 334
 None
 1.08A 3ls4L-3pryA:
undetectable		 3ls4L-3pryA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 3pry HEAT SHOCK PROTEIN
HSP 90-BETA
(Homo
sapiens) 		3 / 3 TYR A 426
MET A 513
LEU A 469
 None
 1.01A 3vw1D-3pryA:
undetectable		 3vw1D-3pryA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 3pry HEAT SHOCK PROTEIN
HSP 90-BETA
(Homo
sapiens) 		5 / 12 PHE A 376
ILE A 335
LEU A 374
LEU A 413
PHE A 429
 None
 1.25A 5im2A-3pryA:
undetectable		 5im2A-3pryA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 3pry HEAT SHOCK PROTEIN
HSP 90-BETA
(Homo
sapiens) 		4 / 8 LEU A 533
VAL A 522
MET A 476
TYR A 472
 None
 0.98A 5nu7A-3pryA:
undetectable		 5nu7A-3pryA:
21.11