SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ps5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6
(Homo
sapiens) 		3 / 3 ARG A 286
GLY A 298
ASP A 300
 None
 0.57A 1kf6A-3ps5A:
2.2
1kf6B-3ps5A:
undetectable		 1kf6A-3ps5A:
22.31
1kf6B-3ps5A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAT_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6
(Homo
sapiens) 		5 / 11 VAL A 451
ILE A 450
LEU A 395
ILE A 409
PHE A 335
 None
 1.35A 1yatA-3ps5A:
undetectable		 1yatA-3ps5A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6
(Homo
sapiens) 		3 / 3 LYS A 521
GLY A 427
PRO A 426
 None
 0.97A 2hreB-3ps5A:
undetectable		 2hreB-3ps5A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6
(Homo
sapiens) 		4 / 5 PRO A 268
PRO A 297
ILE A 296
GLY A 298
 None
 1.16A 2jkjD-3ps5A:
undetectable		 2jkjD-3ps5A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6
(Homo
sapiens) 		4 / 5 PRO A 268
PRO A 297
ILE A 296
GLY A 298
 None
 1.15A 2jkjF-3ps5A:
undetectable		 2jkjF-3ps5A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6
(Homo
sapiens) 		5 / 12 MET A 470
LEU A 430
ILE A 449
PRO A 423
TRP A 417
 None
 1.37A 2pnjB-3ps5A:
undetectable		 2pnjB-3ps5A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6
(Homo
sapiens) 		4 / 8 SER A 453
VAL A 422
GLY A 421
TRP A 417
 SO4  A 599 (-2.6A)
None
None
None
 0.77A 2qd3A-3ps5A:
undetectable		 2qd3A-3ps5A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6
(Homo
sapiens) 		3 / 3 ASN A 274
ASN A 303
ARG A 495
 None
 0.75A 2rlcA-3ps5A:
undetectable		 2rlcA-3ps5A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6
(Homo
sapiens) 		5 / 8 LEU A 150
LEU A 124
ALA A 126
HIS A 112
MET A 115
 None
 1.49A 2wekA-3ps5A:
undetectable		 2wekA-3ps5A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6
(Homo
sapiens) 		4 / 8 THR A 320
LEU A 312
ASP A 315
GLU A 441
 None
 0.90A 2zw9A-3ps5A:
undetectable		 2zw9A-3ps5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6
(Homo
sapiens) 		3 / 3 ARG A 286
ASP A 334
ASN A 270
 None
 0.90A 2zzmA-3ps5A:
undetectable		 2zzmA-3ps5A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6
(Homo
sapiens) 		5 / 10 ILE A 512
ILE A 508
VAL A 499
GLY A 461
LEU A 433
 None
 1.19A 3em0A-3ps5A:
undetectable		 3em0A-3ps5A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6
(Homo
sapiens) 		4 / 5 PHE A 244
ILE A 488
ASN A 225
PHE A 248
 None
 1.35A 3octA-3ps5A:
undetectable		 3octA-3ps5A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6
(Homo
sapiens) 		3 / 3 LYS A 195
GLU A 192
TRP A 110
 None
 1.23A 3v4tH-3ps5A:
undetectable		 3v4tH-3ps5A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6
(Homo
sapiens) 		5 / 9 LEU A 523
ILE A 466
LEU A 469
ILE A 482
ILE A 223
 None
 1.25A 3zosB-3ps5A:
undetectable		 3zosB-3ps5A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6
(Homo
sapiens) 		4 / 8 TYR A 505
ARG A 109
VAL A 218
GLN A 485
 None
 0.79A 4em2A-3ps5A:
undetectable		 4em2A-3ps5A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6
(Homo
sapiens) 		4 / 7 GLY A 497
ILE A 279
ASN A 303
GLN A 489
 None
 1.00A 4g0vA-3ps5A:
undetectable		 4g0vA-3ps5A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6
(Homo
sapiens) 		4 / 7 LEU A 230
VAL A 227
TYR A 214
GLU A 247
 None
 1.03A 4lb2A-3ps5A:
undetectable		 4lb2A-3ps5A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6
(Homo
sapiens) 		5 / 12 LEU A 209
VAL A 207
ILE A 199
LEU A 187
LEU A 190
 None
 1.36A 4yvpB-3ps5A:
undetectable		 4yvpB-3ps5A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6
(Homo
sapiens) 		4 / 6 GLY A 497
GLU A 255
ARG A 492
ASN A 258
 None
 1.10A 4zbqA-3ps5A:
undetectable		 4zbqA-3ps5A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6
(Homo
sapiens) 		4 / 8 ILE A 449
VAL A 346
SER A 442
GLU A 441
 None
 1.08A 5dqyA-3ps5A:
undetectable		 5dqyA-3ps5A:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6
(Homo
sapiens) 		5 / 9 VAL A 510
PHE A 507
TYR A 414
ILE A 466
LEU A 430
 None
 1.39A 5e4dA-3ps5A:
undetectable		 5e4dA-3ps5A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6
(Homo
sapiens) 		6 / 11 VAL A 510
PHE A 507
TYR A 414
ILE A 463
ILE A 466
LEU A 430
 None
 1.34A 5e4dB-3ps5A:
undetectable		 5e4dB-3ps5A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_B_ACRB1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6
(Homo
sapiens) 		5 / 9 GLU A 224
GLU A 247
TYR A 509
GLY A 243
TYR A 214
 None
 1.44A 5lrbB-3ps5A:
0.6		 5lrbB-3ps5A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6
(Homo
sapiens) 		4 / 8 TYR A 509
TYR A 505
ILE A 488
ILE A 466
 None
 0.88A 5mzrE-3ps5A:
undetectable		 5mzrE-3ps5A:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6
(Homo
sapiens) 		3 / 3 VAL A 332
TYR A 364
GLU A 329
 None
 0.89A 5zmqD-3ps5A:
undetectable
5zmqE-3ps5A:
undetectable		 5zmqD-3ps5A:
14.96
5zmqE-3ps5A:
7.84