SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ps9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		3 / 4 VAL A  62
TRP A 153
TRP A 175
 None
 1.31A 1gmkC-3ps9A:
undetectable
1gmkD-3ps9A:
undetectable		 1gmkC-3ps9A:
2.20
1gmkD-3ps9A:
2.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 8 ASN A 323
LEU A 322
TYR A 400
LEU A 372
 None
 1.07A 1hk2A-3ps9A:
undetectable		 1hk2A-3ps9A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 8 GLU A  64
GLY A  66
GLU A 101
ASP A 156
 SAM  A 670 (-4.0A)
SAM  A 670 (-3.5A)
SAM  A 670 (-2.6A)
SAM  A 670 (-3.5A)
 0.50A 1jg4A-3ps9A:
5.8		 1jg4A-3ps9A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 5 GLY A 309
GLN A 308
TRP A 405
VAL A 498
 CL  A 671 (-3.4A)
None
None
None
 1.13A 1p6kB-3ps9A:
undetectable		 1p6kB-3ps9A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 GLU A  64
GLY A  66
GLY A  68
ASP A 156
ILE A 157
 SAM  A 670 (-4.0A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.2A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.8A)
 0.57A 1qaoA-3ps9A:
undetectable		 1qaoA-3ps9A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 7 PHE A 180
ASN A 185
TRP A 189
SER A  65
 SAM  A 670 (-3.6A)
SAM  A 670 ( 4.1A)
None
None
 1.23A 1rqpB-3ps9A:
2.4		 1rqpB-3ps9A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 5 GLY A 309
GLN A 308
TRP A 405
VAL A 498
 CL  A 671 (-3.4A)
None
None
None
 1.16A 1rs6B-3ps9A:
undetectable		 1rs6B-3ps9A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 10 ALA A  63
PHE A  97
LEU A  76
GLY A  44
PHE A  42
 None
 1.39A 1uhoA-3ps9A:
undetectable		 1uhoA-3ps9A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 10 ALA A  63
PHE A  97
LEU A  76
GLY A  45
PHE A  42
 None
 1.40A 1uhoA-3ps9A:
undetectable		 1uhoA-3ps9A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 7 PRO A 299
GLY A 273
ILE A 269
GLY A 271
 None
FAD  A 669 (-3.3A)
None
FAD  A 669 (-3.5A)
 0.71A 1usqA-3ps9A:
undetectable		 1usqA-3ps9A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 6 PRO A 299
GLY A 273
ILE A 269
GLY A 271
 None
FAD  A 669 (-3.3A)
None
FAD  A 669 (-3.5A)
 0.70A 1usqB-3ps9A:
undetectable		 1usqB-3ps9A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 6 PRO A 299
GLY A 273
ILE A 269
GLY A 271
 None
FAD  A 669 (-3.3A)
None
FAD  A 669 (-3.5A)
 0.73A 1usqC-3ps9A:
undetectable		 1usqC-3ps9A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 6 PRO A 299
GLY A 273
ILE A 269
GLY A 271
 None
FAD  A 669 (-3.3A)
None
FAD  A 669 (-3.5A)
 0.70A 1usqD-3ps9A:
undetectable		 1usqD-3ps9A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 6 PRO A 299
GLY A 273
ILE A 269
GLY A 271
 None
FAD  A 669 (-3.3A)
None
FAD  A 669 (-3.5A)
 0.70A 1usqE-3ps9A:
undetectable		 1usqE-3ps9A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 7 PRO A 299
GLY A 273
ILE A 269
GLY A 271
 None
FAD  A 669 (-3.3A)
None
FAD  A 669 (-3.5A)
 0.69A 1usqF-3ps9A:
undetectable		 1usqF-3ps9A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 8 ASP A 178
THR A  18
PRO A  19
LEU A  11
 SAM  A 670 (-3.4A)
None
None
None
 0.79A 1z2bB-3ps9A:
2.4		 1z2bB-3ps9A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 5 GLY A 309
GLN A 308
TRP A 405
VAL A 498
 CL  A 671 (-3.4A)
None
None
None
 1.12A 1zzqB-3ps9A:
undetectable		 1zzqB-3ps9A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 5 GLY A 309
GLN A 308
TRP A 405
VAL A 498
 CL  A 671 (-3.4A)
None
None
None
 1.13A 1zzuA-3ps9A:
undetectable		 1zzuA-3ps9A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 5 GLY A 309
GLN A 308
TRP A 405
VAL A 498
 CL  A 671 (-3.4A)
None
None
None
 1.16A 1zzuB-3ps9A:
undetectable		 1zzuB-3ps9A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		3 / 3 GLY A  66
GLU A 101
ASP A 178
 SAM  A 670 (-3.5A)
SAM  A 670 (-2.6A)
SAM  A 670 (-3.4A)
 0.32A 2b25B-3ps9A:
9.6		 2b25B-3ps9A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 LEU A 630
VAL A 290
LEU A 292
SER A 276
LEU A 279
 None
 1.20A 2c12C-3ps9A:
undetectable		 2c12C-3ps9A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 11 LEU A 630
VAL A 290
LEU A 292
SER A 276
LEU A 279
 None
 1.16A 2c12F-3ps9A:
undetectable		 2c12F-3ps9A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 6 PRO A 299
GLY A 273
ILE A 269
GLY A 271
 None
FAD  A 669 (-3.3A)
None
FAD  A 669 (-3.5A)
 0.67A 2jkjA-3ps9A:
undetectable		 2jkjA-3ps9A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 6 PRO A 299
GLY A 273
ILE A 269
GLY A 271
 None
FAD  A 669 (-3.3A)
None
FAD  A 669 (-3.5A)
 0.67A 2jkjB-3ps9A:
undetectable		 2jkjB-3ps9A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 6 PRO A 299
GLY A 273
ILE A 269
GLY A 271
 None
FAD  A 669 (-3.3A)
None
FAD  A 669 (-3.5A)
 0.67A 2jkjC-3ps9A:
undetectable		 2jkjC-3ps9A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 7 PRO A 299
GLY A 273
ILE A 269
GLY A 271
 None
FAD  A 669 (-3.3A)
None
FAD  A 669 (-3.5A)
 0.66A 2jkjE-3ps9A:
undetectable		 2jkjE-3ps9A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 7 PRO A 299
GLY A 273
ILE A 269
GLY A 271
 None
FAD  A 669 (-3.3A)
None
FAD  A 669 (-3.5A)
 0.70A 2jklA-3ps9A:
undetectable		 2jklA-3ps9A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 6 PRO A 299
GLY A 273
ILE A 269
GLY A 271
 None
FAD  A 669 (-3.3A)
None
FAD  A 669 (-3.5A)
 0.69A 2jklB-3ps9A:
undetectable		 2jklB-3ps9A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 7 PRO A 299
GLY A 273
ILE A 269
GLY A 271
 None
FAD  A 669 (-3.3A)
None
FAD  A 669 (-3.5A)
 0.72A 2jklC-3ps9A:
undetectable		 2jklC-3ps9A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 7 PRO A 299
GLY A 273
ILE A 269
GLY A 271
 None
FAD  A 669 (-3.3A)
None
FAD  A 669 (-3.5A)
 0.71A 2jklD-3ps9A:
undetectable		 2jklD-3ps9A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 7 PRO A 299
GLY A 273
ILE A 269
GLY A 271
 None
FAD  A 669 (-3.3A)
None
FAD  A 669 (-3.5A)
 0.70A 2jklE-3ps9A:
undetectable		 2jklE-3ps9A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 7 PRO A 299
GLY A 273
ILE A 269
GLY A 271
 None
FAD  A 669 (-3.3A)
None
FAD  A 669 (-3.5A)
 0.70A 2jklF-3ps9A:
undetectable		 2jklF-3ps9A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 5 LEU A 630
LEU A 279
LEU A 292
MET A 634
 None
 1.12A 2oaxF-3ps9A:
undetectable		 2oaxF-3ps9A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 GLY A  66
GLY A  68
LYS A 102
ASP A 156
ASP A 178
 SAM  A 670 (-3.5A)
SAM  A 670 (-3.2A)
SAM  A 670 (-4.9A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.4A)
 0.74A 2pxcA-3ps9A:
4.5		 2pxcA-3ps9A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 GLY A  66
GLY A  70
LYS A 102
ASP A 156
ASP A 178
 SAM  A 670 (-3.5A)
SAM  A 670 ( 4.5A)
SAM  A 670 (-4.9A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.4A)
 0.91A 2pxcA-3ps9A:
4.5		 2pxcA-3ps9A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		3 / 3 LEU A 574
PRO A 575
LEU A 649
 None
 0.50A 2qd5B-3ps9A:
undetectable		 2qd5B-3ps9A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 7 PHE A 180
ASN A 185
TRP A 189
SER A  65
 SAM  A 670 (-3.6A)
SAM  A 670 ( 4.1A)
None
None
 1.26A 2v7uB-3ps9A:
2.4		 2v7uB-3ps9A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 TYR A 521
PHE A 326
LEU A 322
ALA A 569
SER A 617
 None
 1.10A 3apvA-3ps9A:
undetectable		 3apvA-3ps9A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 TYR A 521
PHE A 326
LEU A 322
ALA A 569
SER A 617
 None
 1.09A 3apvB-3ps9A:
undetectable		 3apvB-3ps9A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 GLY A  66
GLY A  68
GLU A 101
LYS A 102
ASP A 156
 SAM  A 670 (-3.5A)
SAM  A 670 (-3.2A)
SAM  A 670 (-2.6A)
SAM  A 670 (-4.9A)
SAM  A 670 (-3.5A)
 0.55A 3fuuA-3ps9A:
undetectable		 3fuuA-3ps9A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 ALA A 275
GLY A 273
LEU A 411
LEU A 279
GLY A 619
 FAD  A 669 (-3.3A)
FAD  A 669 (-3.3A)
None
None
FAD  A 669 (-3.0A)
 1.03A 3g2oA-3ps9A:
10.1		 3g2oA-3ps9A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 ALA A 275
GLY A 273
LEU A 411
LEU A 279
GLY A 619
 FAD  A 669 (-3.3A)
FAD  A 669 (-3.3A)
None
None
FAD  A 669 (-3.0A)
 1.09A 3g2oB-3ps9A:
10.8		 3g2oB-3ps9A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		3 / 3 PRO A 249
LEU A 250
GLN A 170
 None
 0.61A 3hznG-3ps9A:
undetectable
3hznH-3ps9A:
undetectable		 3hznG-3ps9A:
15.29
3hznH-3ps9A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 GLY A  66
GLY A  68
GLY A  70
ASP A 156
ASP A 178
 SAM  A 670 (-3.5A)
SAM  A 670 (-3.2A)
SAM  A 670 ( 4.5A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.4A)
 0.54A 3ihtA-3ps9A:
10.3		 3ihtA-3ps9A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 GLY A  66
GLY A  68
GLY A  70
ASP A 156
ILE A 157
 SAM  A 670 (-3.5A)
SAM  A 670 (-3.2A)
SAM  A 670 ( 4.5A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.8A)
 0.50A 3ihtA-3ps9A:
10.3		 3ihtA-3ps9A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 7 GLY A  66
PHE A  80
PHE A  52
PHE A  97
 SAM  A 670 (-3.5A)
None
None
None
 1.07A 3ko0L-3ps9A:
0.0
3ko0N-3ps9A:
undetectable		 3ko0L-3ps9A:
9.38
3ko0N-3ps9A:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB800_0
(GLUTAMATE RECEPTOR 2)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 10 TYR A 337
SER A 304
LEU A 278
PRO A 299
GLY A 272
 None
FAD  A 669 (-2.5A)
None
None
FAD  A 669 (-3.2A)
 1.49A 3lsfB-3ps9A:
undetectable
3lsfE-3ps9A:
0.0		 3lsfB-3ps9A:
16.34
3lsfE-3ps9A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 4 GLY A  66
GLU A 101
ASP A 156
ASP A 178
 SAM  A 670 (-3.5A)
SAM  A 670 (-2.6A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.4A)
 0.46A 3mb5A-3ps9A:
10.5		 3mb5A-3ps9A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 5 LEU A 372
SER A 327
ARG A 324
LEU A 315
 None
 1.33A 3onnA-3ps9A:
undetectable		 3onnA-3ps9A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 5 LEU A 376
ARG A 324
LEU A 372
PRO A 373
 None
 1.26A 3onnA-3ps9A:
undetectable		 3onnA-3ps9A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		6 / 12 GLY A  68
ASN A  72
ALA A   9
LEU A  71
THR A 106
LEU A 105
 SAM  A 670 (-3.2A)
SAM  A 670 ( 3.7A)
None
SAM  A 670 (-3.8A)
None
None
 1.50A 3p2kB-3ps9A:
7.8		 3p2kB-3ps9A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 7 PRO A 401
TYR A 400
THR A 399
ILE A 398
 None
 0.87A 3p50A-3ps9A:
undetectable		 3p50A-3ps9A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 7 PRO A 401
TYR A 400
THR A 399
ILE A 398
 None
 0.86A 3p50B-3ps9A:
undetectable		 3p50B-3ps9A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 7 PRO A 401
TYR A 400
THR A 399
ILE A 398
 None
 0.86A 3p50C-3ps9A:
undetectable		 3p50C-3ps9A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 7 PRO A 401
TYR A 400
THR A 399
ILE A 398
 None
 0.87A 3p50D-3ps9A:
undetectable		 3p50D-3ps9A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 7 PRO A 401
TYR A 400
THR A 399
ILE A 398
 None
 0.84A 3p50E-3ps9A:
undetectable		 3p50E-3ps9A:
18.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		12 / 12 PHE A  24
GLU A  64
GLY A  66
ASN A  72
LYS A 102
PHE A 103
ASP A 156
ILE A 157
GLY A 179
PHE A 180
ASN A 185
MET A 188
 SAM  A 670 ( 4.5A)
SAM  A 670 (-4.0A)
SAM  A 670 (-3.5A)
SAM  A 670 ( 3.7A)
SAM  A 670 (-4.9A)
SAM  A 670 (-4.8A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.8A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.6A)
SAM  A 670 ( 4.1A)
SAM  A 670 ( 3.9A)
 0.00A 3ps9A-3ps9A:
67.7		 3ps9A-3ps9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		6 / 6 TYR A  28
GLY A  68
THR A  69
LEU A  71
GLU A 101
ASP A 178
 SAM  A 670 (-4.5A)
SAM  A 670 (-3.2A)
SAM  A 670 (-3.6A)
SAM  A 670 (-3.8A)
SAM  A 670 (-2.6A)
SAM  A 670 (-3.4A)
 0.03A 3ps9A-3ps9A:
67.7		 3ps9A-3ps9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 GLU A  64
GLY A  66
GLY A  68
GLY A 179
PHE A 180
 SAM  A 670 (-4.0A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.2A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.6A)
 0.79A 3sglA-3ps9A:
58.3		 3sglA-3ps9A:
60.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		9 / 12 GLU A  64
GLY A  66
GLY A  68
THR A  69
LEU A  71
ASN A  72
LYS A 102
ASP A 156
GLY A 179
 SAM  A 670 (-4.0A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.2A)
SAM  A 670 (-3.6A)
SAM  A 670 (-3.8A)
SAM  A 670 ( 3.7A)
SAM  A 670 (-4.9A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.5A)
 0.43A 3sglA-3ps9A:
58.3		 3sglA-3ps9A:
60.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 GLY A  66
GLY A  68
LYS A 102
ASP A 156
PHE A  24
 SAM  A 670 (-3.5A)
SAM  A 670 (-3.2A)
SAM  A 670 (-4.9A)
SAM  A 670 (-3.5A)
SAM  A 670 ( 4.5A)
 1.06A 3sglA-3ps9A:
58.3		 3sglA-3ps9A:
60.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 6 GLY A 524
VAL A 566
HIS A 463
SER A 478
 None
 1.14A 3tj7A-3ps9A:
undetectable
3tj7B-3ps9A:
undetectable		 3tj7A-3ps9A:
15.34
3tj7B-3ps9A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 6 GLY A 524
VAL A 566
HIS A 463
SER A 478
 None
 1.10A 3tj7C-3ps9A:
undetectable
3tj7D-3ps9A:
undetectable		 3tj7C-3ps9A:
15.34
3tj7D-3ps9A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 TYR A  28
GLY A  66
GLY A  68
ASN A  72
PHE A 180
 SAM  A 670 (-4.5A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.2A)
SAM  A 670 ( 3.7A)
SAM  A 670 (-3.6A)
 0.22A 3vywA-3ps9A:
22.3		 3vywA-3ps9A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 6 GLU A 101
ASP A 156
ASP A 178
ASN A 185
 SAM  A 670 (-2.6A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.4A)
SAM  A 670 ( 4.1A)
 0.64A 3vywA-3ps9A:
22.3		 3vywA-3ps9A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		6 / 12 TYR A  28
GLY A  66
GLY A  68
ASN A  72
PHE A 180
ASN A 185
 SAM  A 670 (-4.5A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.2A)
SAM  A 670 ( 3.7A)
SAM  A 670 (-3.6A)
SAM  A 670 ( 4.1A)
 0.48A 3vywB-3ps9A:
22.8		 3vywB-3ps9A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 TYR A  28
GLY A  66
GLY A  70
ASN A  72
PHE A 180
 SAM  A 670 (-4.5A)
SAM  A 670 (-3.5A)
SAM  A 670 ( 4.5A)
SAM  A 670 ( 3.7A)
SAM  A 670 (-3.6A)
 0.31A 3vywC-3ps9A:
22.5		 3vywC-3ps9A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 6 GLY A  68
GLU A 101
ASP A 156
ASP A 178
ASN A 185
 SAM  A 670 (-3.2A)
SAM  A 670 (-2.6A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.4A)
SAM  A 670 ( 4.1A)
 0.56A 3vywC-3ps9A:
22.5		 3vywC-3ps9A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 TYR A  28
GLY A  66
GLY A  68
ASN A  72
PHE A 180
 SAM  A 670 (-4.5A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.2A)
SAM  A 670 ( 3.7A)
SAM  A 670 (-3.6A)
 0.26A 3vywD-3ps9A:
22.6		 3vywD-3ps9A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 5 GLU A 101
ASP A 156
ASP A 178
ASN A 185
 SAM  A 670 (-2.6A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.4A)
SAM  A 670 ( 4.1A)
 0.71A 3vywD-3ps9A:
22.6		 3vywD-3ps9A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		3 / 3 LEU A 574
PRO A 575
LEU A 649
 None
 0.48A 3w1wB-3ps9A:
undetectable		 3w1wB-3ps9A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 11 GLN A   7
ASN A  10
GLY A  68
GLU A  64
MET A 188
 None
None
SAM  A 670 (-3.2A)
SAM  A 670 (-4.0A)
SAM  A 670 ( 3.9A)
 1.44A 4a6nB-3ps9A:
15.5		 4a6nB-3ps9A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 GLY A  66
GLY A  68
LYS A 102
ASP A 156
ASP A 178
 SAM  A 670 (-3.5A)
SAM  A 670 (-3.2A)
SAM  A 670 (-4.9A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.4A)
 0.85A 4ctjA-3ps9A:
5.5		 4ctjA-3ps9A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 GLY A  66
GLY A  68
LYS A 102
ASP A 156
ASP A 178
 SAM  A 670 (-3.5A)
SAM  A 670 (-3.2A)
SAM  A 670 (-4.9A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.4A)
 0.82A 4ctkA-3ps9A:
3.7		 4ctkA-3ps9A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 GLY A  66
GLY A  70
LYS A 102
ASP A 156
ASP A 178
 SAM  A 670 (-3.5A)
SAM  A 670 ( 4.5A)
SAM  A 670 (-4.9A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.4A)
 0.88A 4ctkA-3ps9A:
3.7		 4ctkA-3ps9A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 LEU A 411
LEU A 418
ALA A 419
GLN A 422
ALA A 282
 None
 0.99A 4fn9A-3ps9A:
undetectable		 4fn9A-3ps9A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 4 GLY A 309
GLN A 308
TRP A 405
VAL A 498
 CL  A 671 (-3.4A)
None
None
None
 1.16A 4kcnB-3ps9A:
0.2		 4kcnB-3ps9A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 7 ASP A 534
SER A 520
ALA A 480
SER A 525
 None
 1.27A 4lv9A-3ps9A:
undetectable
4lv9B-3ps9A:
undetectable		 4lv9A-3ps9A:
19.77
4lv9B-3ps9A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 7 ARG A 334
GLN A 402
GLU A 375
ARG A 107
 None
 1.21A 4mv7A-3ps9A:
3.4		 4mv7A-3ps9A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 5 VAL A 588
ILE A 629
PRO A 581
THR A 570
 None
 1.12A 4ze1A-3ps9A:
undetectable		 4ze1A-3ps9A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		3 / 3 ASP A 582
ASN A 579
PHE A 257
 None
 0.73A 5dsgB-3ps9A:
undetectable		 5dsgB-3ps9A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 GLY A  66
GLY A  68
LYS A 102
ASP A 156
ASP A 178
 SAM  A 670 (-3.5A)
SAM  A 670 (-3.2A)
SAM  A 670 (-4.9A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.4A)
 0.79A 5e9qC-3ps9A:
5.4		 5e9qC-3ps9A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 GLY A  66
GLY A  68
LYS A 102
ASP A 156
ASP A 178
 SAM  A 670 (-3.5A)
SAM  A 670 (-3.2A)
SAM  A 670 (-4.9A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.4A)
 0.79A 5ehgA-3ps9A:
5.2		 5ehgA-3ps9A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 GLY A  66
GLY A  70
LYS A 102
ASP A 156
ASP A 178
 SAM  A 670 (-3.5A)
SAM  A 670 ( 4.5A)
SAM  A 670 (-4.9A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.4A)
 0.87A 5ehgA-3ps9A:
5.2		 5ehgA-3ps9A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 GLY A  66
GLY A  68
LYS A 102
ASP A 156
ASP A 178
 SAM  A 670 (-3.5A)
SAM  A 670 (-3.2A)
SAM  A 670 (-4.9A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.4A)
 0.87A 5eifA-3ps9A:
5.5		 5eifA-3ps9A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 6 TYR A  28
GLY A  66
GLU A 101
ASP A 156
 SAM  A 670 (-4.5A)
SAM  A 670 (-3.5A)
SAM  A 670 (-2.6A)
SAM  A 670 (-3.5A)
 0.96A 5emlA-3ps9A:
6.1		 5emlA-3ps9A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 7 GLY A  66
GLY A  68
GLU A 101
ASP A 156
ASP A 178
 SAM  A 670 (-3.5A)
SAM  A 670 (-3.2A)
SAM  A 670 (-2.6A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.4A)
 0.61A 5ergB-3ps9A:
10.5		 5ergB-3ps9A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 7 GLY A  66
GLY A  68
GLU A 101
PHE A 103
ASP A 178
 SAM  A 670 (-3.5A)
SAM  A 670 (-3.2A)
SAM  A 670 (-2.6A)
SAM  A 670 (-4.8A)
SAM  A 670 (-3.4A)
 1.12A 5ergB-3ps9A:
10.5		 5ergB-3ps9A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 8 LEU A  95
PHE A  97
PHE A 176
PRO A 638
 None
 1.03A 5m0oC-3ps9A:
undetectable		 5m0oC-3ps9A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 8 GLY A  66
GLU A 101
LYS A 102
ASP A 156
 SAM  A 670 (-3.5A)
SAM  A 670 (-2.6A)
SAM  A 670 (-4.9A)
SAM  A 670 (-3.5A)
 0.58A 5mvsB-3ps9A:
8.6		 5mvsB-3ps9A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 8 PRO A 401
TYR A 400
THR A 399
ILE A 398
 None
 0.94A 5mzrE-3ps9A:
undetectable		 5mzrE-3ps9A:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 7 GLY A  66
GLU A 101
ASP A 178
ASN A 185
 SAM  A 670 (-3.5A)
SAM  A 670 (-2.6A)
SAM  A 670 (-3.4A)
SAM  A 670 ( 4.1A)
 0.72A 5n5dB-3ps9A:
11.5		 5n5dB-3ps9A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 6 PHE A 176
LEU A 177
SER A  99
GLY A  66
 None
None
None
SAM  A 670 (-3.5A)
 1.10A 5o4yF-3ps9A:
undetectable		 5o4yF-3ps9A:
3.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 6 PHE A 612
LEU A 459
SER A 276
GLY A 271
 None
None
None
FAD  A 669 (-3.5A)
 1.13A 5o4yF-3ps9A:
undetectable		 5o4yF-3ps9A:
3.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 5 GLY A 309
GLN A 308
TRP A 405
VAL A 498
 CL  A 671 (-3.4A)
None
None
None
 1.16A 5vunA-3ps9A:
undetectable		 5vunA-3ps9A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 4 GLY A 309
GLN A 308
TRP A 405
VAL A 498
 CL  A 671 (-3.4A)
None
None
None
 1.15A 5vunB-3ps9A:
0.0		 5vunB-3ps9A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 4 GLY A 309
GLN A 308
TRP A 405
VAL A 498
 CL  A 671 (-3.4A)
None
None
None
 1.20A 5vuoA-3ps9A:
0.1		 5vuoA-3ps9A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 4 ASP A 533
SER A 531
ASP A 534
HIS A 522
 None
 1.32A 5wyqB-3ps9A:
undetectable		 5wyqB-3ps9A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 GLY A  66
GLY A  70
LYS A 102
ASP A 156
ASP A 178
 SAM  A 670 (-3.5A)
SAM  A 670 ( 4.5A)
SAM  A 670 (-4.9A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.4A)
 0.90A 5wz1A-3ps9A:
5.4		 5wz1A-3ps9A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 GLY A  66
GLY A  70
LYS A 102
ASP A 156
ASP A 178
 SAM  A 670 (-3.5A)
SAM  A 670 ( 4.5A)
SAM  A 670 (-4.9A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.4A)
 0.92A 5wz1C-3ps9A:
4.3		 5wz1C-3ps9A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 GLY A  66
GLY A  70
LYS A 102
ASP A 156
ASP A 178
 SAM  A 670 (-3.5A)
SAM  A 670 ( 4.5A)
SAM  A 670 (-4.9A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.4A)
 0.94A 5wz1D-3ps9A:
5.4		 5wz1D-3ps9A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 GLY A  66
GLY A  70
LYS A 102
ASP A 156
ASP A 178
 SAM  A 670 (-3.5A)
SAM  A 670 ( 4.5A)
SAM  A 670 (-4.9A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.4A)
 0.93A 5wz1E-3ps9A:
5.4		 5wz1E-3ps9A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 GLY A  66
GLY A  70
LYS A 102
ASP A 156
ASP A 178
 SAM  A 670 (-3.5A)
SAM  A 670 ( 4.5A)
SAM  A 670 (-4.9A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.4A)
 0.95A 5wz1F-3ps9A:
5.3		 5wz1F-3ps9A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 GLY A  66
GLY A  70
LYS A 102
ASP A 156
ASP A 178
 SAM  A 670 (-3.5A)
SAM  A 670 ( 4.5A)
SAM  A 670 (-4.9A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.4A)
 0.93A 5wz1G-3ps9A:
4.2		 5wz1G-3ps9A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 GLY A  66
GLY A  70
LYS A 102
ASP A 156
ASP A 178
 SAM  A 670 (-3.5A)
SAM  A 670 ( 4.5A)
SAM  A 670 (-4.9A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.4A)
 0.89A 5wz1H-3ps9A:
5.2		 5wz1H-3ps9A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 GLY A  66
GLY A  68
LYS A 102
ASP A 156
ASP A 178
 SAM  A 670 (-3.5A)
SAM  A 670 (-3.2A)
SAM  A 670 (-4.9A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.4A)
 0.72A 5wz2A-3ps9A:
5.4		 5wz2A-3ps9A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 GLY A  66
GLY A  68
LYS A 102
ASP A 156
ASP A 178
 SAM  A 670 (-3.5A)
SAM  A 670 (-3.2A)
SAM  A 670 (-4.9A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.4A)
 0.69A 5wz2B-3ps9A:
5.5		 5wz2B-3ps9A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		5 / 12 GLY A  66
GLY A  70
LYS A 102
ASP A 156
ASP A 178
 SAM  A 670 (-3.5A)
SAM  A 670 ( 4.5A)
SAM  A 670 (-4.9A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.4A)
 0.86A 5wz2B-3ps9A:
5.5		 5wz2B-3ps9A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 7 PHE A  67
GLY A  66
GLY A 179
THR A 161
 None
SAM  A 670 (-3.5A)
SAM  A 670 (-3.5A)
None
 0.79A 5ybbB-3ps9A:
7.9		 5ybbB-3ps9A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		4 / 4 GLY A 309
GLN A 308
TRP A 405
VAL A 498
 CL  A 671 (-3.4A)
None
None
None
 1.12A 6auuB-3ps9A:
0.0		 6auuB-3ps9A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC
(Escherichia
coli) 		6 / 10 VAL A  62
ALA A 174
LEU A  95
LEU A  43
THR A 206
LEU A  76
 None
 1.33A 6f5uA-3ps9A:
0.6
6f5uB-3ps9A:
undetectable		 6f5uA-3ps9A:
8.96
6f5uB-3ps9A:
9.80