SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3psf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 738
SER A 752
ALA A 810
ILE A 750
 None
 1.06A 1fxhA-3psfA:
undetectable
1fxhB-3psfA:
2.8		 1fxhA-3psfA:
12.15
1fxhB-3psfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 971
LEU A 973
VAL A 935
LEU A 963
 None
 0.95A 1hk3A-3psfA:
2.3		 1hk3A-3psfA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK5_A_T44A1008_1
(SERUM ALBUMIN)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		5 / 10 ASP A 468
GLU A 474
VAL A 448
TYR A 451
VAL A 434
 None
 1.43A 1hk5A-3psfA:
2.7		 1hk5A-3psfA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 909
LEU A 916
ALA A 919
LEU A 920
 None
 0.59A 1hwiB-3psfA:
undetectable		 1hwiB-3psfA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 909
LEU A 916
ALA A 919
LEU A 920
 None
 0.57A 1hwiD-3psfA:
undetectable		 1hwiD-3psfA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 909
LEU A 916
ALA A 919
LEU A 920
 None
 0.57A 1hwiC-3psfA:
undetectable		 1hwiC-3psfA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 990
ALA A 994
TYR A1026
ILE A 999
 None
 1.19A 1oniH-3psfA:
undetectable
1oniI-3psfA:
undetectable		 1oniH-3psfA:
9.13
1oniI-3psfA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 962
LEU A 973
PHE A 954
SER A 932
 None
 1.13A 1wrlC-3psfA:
undetectable		 1wrlC-3psfA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 391
ARG A 395
ASP A1025
GLU A1024
 None
 1.16A 2qebA-3psfA:
undetectable		 2qebA-3psfA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 979
ARG A 976
ILE A 980
 None
 0.68A 2xn5B-3psfA:
undetectable		 2xn5B-3psfA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 848
ILE A 813
ASP A 851
SER A1123
 None
 1.09A 2xytE-3psfA:
undetectable		 2xytE-3psfA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 848
ILE A 813
ASP A 851
SER A1123
 None
 1.09A 2xytH-3psfA:
undetectable		 2xytH-3psfA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 848
ILE A 813
ASP A 851
SER A1123
 None
 1.09A 2xytI-3psfA:
undetectable		 2xytI-3psfA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 777
VAL A 768
CYH A 806
TYR A 780
 None
 1.27A 2xz5A-3psfA:
undetectable
2xz5C-3psfA:
undetectable		 2xz5A-3psfA:
13.15
2xz5C-3psfA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 777
VAL A 768
CYH A 806
TYR A 780
 None
 1.26A 2xz5C-3psfA:
undetectable
2xz5D-3psfA:
undetectable		 2xz5C-3psfA:
13.15
2xz5D-3psfA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 777
VAL A 768
CYH A 806
TYR A 780
 None
 1.27A 2xz5D-3psfA:
undetectable
2xz5E-3psfA:
undetectable		 2xz5D-3psfA:
13.15
2xz5E-3psfA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		4 / 7 ARG A 882
PHE A 776
ILE A 777
ASN A 771
 None
 1.17A 2zseA-3psfA:
undetectable		 2zseA-3psfA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 450
HIS A 535
ALA A 521
SER A 520
TYR A 472
 None
 1.37A 3apvA-3psfA:
undetectable		 3apvA-3psfA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 695
ILE A 519
GLY A 518
ASN A 688
THR A 676
 None
 1.15A 3eeyA-3psfA:
undetectable		 3eeyA-3psfA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 695
ILE A 519
GLY A 518
ASN A 688
THR A 676
 None
 1.15A 3eeyB-3psfA:
undetectable		 3eeyB-3psfA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 695
ILE A 519
GLY A 518
ASN A 688
THR A 676
 None
 1.14A 3eeyC-3psfA:
undetectable		 3eeyC-3psfA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 695
ILE A 519
GLY A 518
ASN A 688
THR A 676
 None
 1.14A 3eeyD-3psfA:
undetectable		 3eeyD-3psfA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 695
ILE A 519
GLY A 518
ASN A 688
THR A 676
 None
 1.16A 3eeyE-3psfA:
undetectable		 3eeyE-3psfA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 695
ILE A 519
GLY A 518
ASN A 688
THR A 676
 None
 1.15A 3eeyH-3psfA:
undetectable		 3eeyH-3psfA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 695
ILE A 519
GLY A 518
ASN A 688
THR A 676
 None
 1.15A 3eeyI-3psfA:
2.3		 3eeyI-3psfA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 695
ILE A 519
GLY A 518
ASN A 688
THR A 676
 None
 1.14A 3eeyJ-3psfA:
2.5		 3eeyJ-3psfA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 894
TYR A 891
ILE A 855
ALA A 854
LEU A 880
 None
 0.78A 3n8zB-3psfA:
undetectable		 3n8zB-3psfA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 888
LEU A 733
ALA A 892
ASN A 893
LEU A 894
 None
 0.84A 3r9cA-3psfA:
undetectable		 3r9cA-3psfA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 799
ALA A 767
ILE A 750
ILE A 803
ILE A 802
 None
 1.02A 3s53B-3psfA:
undetectable		 3s53B-3psfA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 799
ALA A 767
ASP A 779
ILE A 750
ILE A 803
ILE A 802
 None
 1.31A 3s54B-3psfA:
undetectable		 3s54B-3psfA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		3 / 3 GLN A 735
PHE A1112
TYR A 883
 None
 0.85A 3ucjB-3psfA:
undetectable		 3ucjB-3psfA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		3 / 3 GLN A 735
PHE A1112
TYR A 883
 None
 0.88A 3ucjA-3psfA:
undetectable		 3ucjA-3psfA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 989
GLY A 953
SER A 952
SER A 993
 None
 0.75A 3v7pA-3psfA:
undetectable		 3v7pA-3psfA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		5 / 10 ALA A1079
LEU A1028
LEU A1073
ASN A1074
ILE A1097
 None
 1.13A 3wdmB-3psfA:
undetectable		 3wdmB-3psfA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		5 / 12 SER A 917
THR A 731
ILE A 904
PHE A 729
HIS A 727
 None
 1.24A 4c49C-3psfA:
undetectable		 4c49C-3psfA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		5 / 12 SER A 917
THR A 731
ILE A 904
PHE A 729
HIS A 727
 None
 1.30A 4c49D-3psfA:
undetectable		 4c49D-3psfA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 881
ALA A 810
ILE A 846
GLY A 812
ILE A 847
 None
 1.05A 4eatB-3psfA:
undetectable		 4eatB-3psfA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 933
ALA A 945
SER A 993
LEU A 979
VAL A 935
 None
 1.48A 4kyaB-3psfA:
undetectable		 4kyaB-3psfA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 933
ALA A 945
SER A 993
LEU A 979
VAL A 935
 None
 1.48A 4kyaH-3psfA:
undetectable		 4kyaH-3psfA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 846
ALA A 767
LEU A 751
LEU A 799
ILE A 782
 None
 1.14A 4lnwA-3psfA:
undetectable		 4lnwA-3psfA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 846
ALA A 767
LEU A 751
LEU A 799
ILE A 782
 None
 1.16A 4lnxA-3psfA:
undetectable		 4lnxA-3psfA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 528
ILE A 519
SER A 520
LEU A 582
 None
 0.97A 4m51A-3psfA:
undetectable		 4m51A-3psfA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 773
ASN A 809
ASP A 775
 None
 0.81A 4o1eA-3psfA:
undetectable		 4o1eA-3psfA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 548
PHE A 689
ARG A 690
 None
 0.93A 4xr4B-3psfA:
undetectable		 4xr4B-3psfA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		4 / 8 LEU A1016
ASP A1025
ALA A1029
VAL A1032
 None
 0.85A 4zbqA-3psfA:
undetectable		 4zbqA-3psfA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 943
VAL A 899
GLY A 815
THR A 754
LEU A 880
 None
 1.38A 5esgA-3psfA:
undetectable		 5esgA-3psfA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 795
ILE A 765
LEU A 799
LEU A 751
PHE A 823
 None
 1.08A 5im2A-3psfA:
undetectable		 5im2A-3psfA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 387
PRO A 389
GLY A 953
ARG A 325
 None
 0.93A 5jcnB-3psfA:
undetectable		 5jcnB-3psfA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 758
THR A 820
ASN A 817
 None
 0.68A 5odiG-3psfA:
3.8		 5odiG-3psfA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 966
SER A 965
PHE A 962
ASP A 961
 None
 0.92A 5om3A-3psfA:
undetectable
5om3B-3psfA:
undetectable		 5om3A-3psfA:
7.03
5om3B-3psfA:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		4 / 8 LEU A1060
VAL A1032
LEU A1102
ILE A1097
 None
 0.90A 5v0vA-3psfA:
2.0		 5v0vA-3psfA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		4 / 5 ARG A1066
PHE A1056
LEU A1037
LEU A1016
 None
 1.10A 5veuH-3psfA:
undetectable		 5veuH-3psfA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 957
MET A 310
THR A 311
LEU A 305
 None
 1.35A 5w97J-3psfA:
undetectable		 5w97J-3psfA:
4.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 957
MET A 310
THR A 311
LEU A 305
 None
 1.37A 5x1fW-3psfA:
undetectable		 5x1fW-3psfA:
4.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 925
TYR A 950
GLU A 387
 None
 0.72A 5zmqD-3psfA:
undetectable
5zmqE-3psfA:
undetectable		 5zmqD-3psfA:
9.32
5zmqE-3psfA:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		3 / 3 GLU A1038
ASP A1040
PRO A1041
 None
 0.72A 6berA-3psfA:
undetectable		 6berA-3psfA:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 928
ASN A 929
ASN A 992
GLU A 387
 None
 1.23A 6h7uA-3psfA:
undetectable		 6h7uA-3psfA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 873
TYR A 876
ILE A 844
GLY A 815
 None
 1.08A 6hd6A-3psfA:
undetectable		 6hd6A-3psfA:
5.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 873
ALA A 854
LEU A1124
ASP A 851
LEU A 880
 None
 1.01A 6ie8A-3psfA:
undetectable		 6ie8A-3psfA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 325
PHE A 390
PHE A 954
 None
 0.89A 6nknC-3psfA:
undetectable
6nknJ-3psfA:
undetectable		 6nknC-3psfA:
11.54
6nknJ-3psfA:
4.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 957
MET A 310
THR A 311
LEU A 305
 None
 1.31A 6nknJ-3psfA:
undetectable		 6nknJ-3psfA:
4.53