SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3psq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 3psq HYPOTHETICAL
EXPORTED PROTEIN
(Streptococcus
pyogenes) 		4 / 5 LEU A  71
ILE A 123
LEU A 122
SER A 121
 None
 0.82A 2byoA-3psqA:
undetectable		 2byoA-3psqA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TF1_A_ACTA191_0
(METHYL-ACCEPTING
CHEMOTAXIS PROTEIN)		 3psq HYPOTHETICAL
EXPORTED PROTEIN
(Streptococcus
pyogenes) 		4 / 5 LYS A 200
THR A 172
ILE A 170
PHE A 180
 None
None
None
CL  A 310 ( 4.1A)
 0.96A 3tf1A-3psqA:
undetectable		 3tf1A-3psqA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3psq HYPOTHETICAL
EXPORTED PROTEIN
(Streptococcus
pyogenes) 		3 / 3 LYS A 161
GLU A 155
TRP A  70
 ZN  A 320 ( 4.3A)
ZN  A 320 ( 2.5A)
None
 1.16A 3v4tH-3psqA:
undetectable		 3v4tH-3psqA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3psq HYPOTHETICAL
EXPORTED PROTEIN
(Streptococcus
pyogenes) 		5 / 11 SER A  95
SER A 105
ILE A  63
VAL A  67
LEU A  60
 None
 1.07A 3w67A-3psqA:
undetectable		 3w67A-3psqA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3psq HYPOTHETICAL
EXPORTED PROTEIN
(Streptococcus
pyogenes) 		5 / 12 SER A  95
SER A 105
ILE A  63
VAL A  67
LEU A  60
 None
 1.14A 3w68A-3psqA:
undetectable		 3w68A-3psqA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDC_A_ASDA404_1
(3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE)		 3psq HYPOTHETICAL
EXPORTED PROTEIN
(Streptococcus
pyogenes) 		5 / 12 HIS A  77
LEU A  71
LEU A 137
ASN A 139
PHE A 134
 None
 1.42A 4qdcA-3psqA:
undetectable		 4qdcA-3psqA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3psq HYPOTHETICAL
EXPORTED PROTEIN
(Streptococcus
pyogenes) 		5 / 12 ASP A 118
SER A 121
THR A 158
THR A 156
ALA A  69
 ACY  A 242 (-3.8A)
None
None
None
None
 1.43A 4u15B-3psqA:
undetectable		 4u15B-3psqA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 3psq HYPOTHETICAL
EXPORTED PROTEIN
(Streptococcus
pyogenes) 		5 / 12 THR A  76
GLY A  75
PHE A 116
VAL A 216
ILE A 123
 None
ZN  A 314 ( 4.4A)
None
None
None
 1.04A 5tuiB-3psqA:
undetectable		 5tuiB-3psqA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 3psq HYPOTHETICAL
EXPORTED PROTEIN
(Streptococcus
pyogenes) 		4 / 7 ILE A 123
LEU A 137
PHE A 140
THR A 172
 None
 0.97A 5vc0A-3psqA:
undetectable		 5vc0A-3psqA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3psq HYPOTHETICAL
EXPORTED PROTEIN
(Streptococcus
pyogenes) 		4 / 6 GLN A  84
PHE A 107
LEU A  71
PHE A 152
 None
 1.12A 5zcoP-3psqA:
undetectable
5zcoW-3psqA:
undetectable		 5zcoP-3psqA:
19.10
5zcoW-3psqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 3psq HYPOTHETICAL
EXPORTED PROTEIN
(Streptococcus
pyogenes) 		4 / 5 ALA A 168
TYR A 204
GLN A 235
ILE A 207
 None
EDO  A 239 (-4.9A)
EDO  A 239 ( 4.7A)
EDO  A 239 (-3.9A)
 1.15A 6g9bA-3psqA:
undetectable
6g9bB-3psqA:
undetectable		 6g9bA-3psqA:
16.06
6g9bB-3psqA:
17.09